Lab-Grown Arteries More Elastic Than Ever
February 1, 2011 10:22 AM
comment(s) - last by
(Source: University of Pittsburgh)
New lab-grown arteries function just like natural inborn arteries with the help of additional elastin for blood flow
Researchers from the
University of Pittsburgh
have created elastic arteries that closely resemble the elasticity of natural blood vessels.
Yadong Wang, study leader and a professor of bioengineering in the University of Pittsburgh's Swanson School of Engineering, along with Donna Stolz, a professor of cell biology and physiology in the University of Pittsburgh's School of Medicine and Kee-Won Lee, a postdoctoral researcher, have
developed elastic arteries
grown outside of the body using smooth muscle cells from adult baboons.
Up until this point, researchers have had a difficult time reproducing elastin in the lab. Some traditional methods, such as using a virus to alter the cell genes or rolling cell sheets into tubes, have worked to an extent, but did not result in this large of an amount of elastin with
The arteries in this particular study are the first arteries grown outside of the body to have a large amount of elastin, which is a protein that helps
by allowing vessels to retract and expand. These lab-made arteries contain 20 percent as much elastin as an "inborn" artery.
To make these arteries, smooth muscle cells from four-year-old baboons were seeded into degradable rubber tubes. The tubes were placed into a bioreactor that pumped a nutrient-rich solution, which was kept at 98.6 degrees Fahrenheit, through the tubes and produced a regular pulse, imitating the human circulatory system. The muscle cells then created proteins that fused together to form the vessel as they grew.
Functional, strong arteries were complete in a three-week period. In lab tests, the researchers found that an artery could handle a burst pressure between 200 and 300 millimeters of mercury (mmHg), where a healthy human blood pressure is below 120 mmHg.
Wang and his team are now looking to develop a vessel that imitates the three-layer structure of a human artery.
was published in
Proceedings of the National Academy of Sciences
This article is over a month old, voting and posting comments is disabled
Pretty cool stuff...
2/1/2011 11:44:53 AM
But I wonder if it is easier than just using the artery in the leg that doctors use to replace arteries near the heart (I'm not sure what it was called)
RE: Pretty cool stuff...
2/1/2011 12:47:35 PM
Doctors harvest your noncritical vein for bypass surgeries. On a note, hopefully they don't make these too elastic that they balloon under pressure. They call them aneurysm when arteries do that.
"My sex life is pretty good" -- Steve Jobs' random musings during the 2010 D8 conference
Researchers Use Nanowires to Turn Blood Flow into Electricity
March 27, 2009, 1:11 PM
Researchers Print Blood Vessels from Ink Jet Printer
August 30, 2007, 3:38 PM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information