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The purple represents the T-cell membrane, where HIV enters through multiple cell receptors   (Source: allthingsstemcell.com)
T-cells are made resistant without any harmful effects to their activity or growth

An international team of researchers has found a new technique that is capable of making T-cells resistant to HIV in such a way that it does not place harm on the T-cells' activity or growth. 

Research for this study was conducted by Hideto Chono, study leader and creator of the new gene therapy tool, along with co-authors from Takara Bio Inc. in Otsu, Shiga, Japan; National Institute of Biomedical Innovation; Seoul National University and ViroMed Co. in Seoul, Korea, and Robert Wood Johnson Medical School in Piscataway, New Jersey. 

To make this anti-HIV gene therapy technique, Chono and the team of researchers used a bacterial gene called mazF, which is an enzyme, or mRNA interferase, that prevents protein synthesis by destroying gene transcripts. MazF is transferred into CD4+ T-cells, and due to the design of the mazF gene therapy vector, HIV activates synthesis of the MazF protein. MazF blocks HIV replication when HIV infects these treated T-lymphocytes, which ultimately makes the T-cells resistant to the infection. 

"The potential of using vectors to express genes within a cell to block viral infection was first considered by David Baltimore in a strategy called 'intracellular immunization,'" said James M. Wilson, MD, Ph.D., Editor-in-Chief, and Director of the Gene Therapy Program at the University of Pennsylvania School of Medicine's Department of Pathology and Laboratory Medicine. "This study illustrates a unique way in which intracellular immunization can be achieved." 

This study, titled "Acquisition of HIV-1 Resistance in T Lymphocytes Using an ACA-Specific E. coli mRNA Interferase," was published in Human Gene Therapy.



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Zombie apocalypse coming!
By Exodite on 1/27/2011 9:18:12 AM , Rating: 1
I smell the T-virus already... :)




RE: Zombie apocalypse coming!
By Brandon Hill (blog) on 1/27/2011 9:24:12 AM , Rating: 5
Man, what is the deal with zombies? Is this the new fad like vampires?


RE: Zombie apocalypse coming!
By Exodite on 1/27/2011 9:32:22 AM , Rating: 1
No no, that's mummies. At least according to Penny Arcade.

I can't take credit for the zombie T-cell reference.


RE: Zombie apocalypse coming!
By SilthDraeth on 1/27/2011 9:51:47 AM , Rating: 2
Are you kidding Brandon? Zombies have been a fad for a long time, at least amongst computer nerds. You fall into that category so I am shocked you aren't on your own local ZDF (Zombie Defense Force).


RE: Zombie apocalypse coming!
By Mitch101 on 1/27/2011 10:28:33 AM , Rating: 2
I hope there is a Left 4 Dead 3 in the works. Can never be too prepared.


RE: Zombie apocalypse coming!
By BushStar on 1/31/2011 5:20:09 AM , Rating: 3
They are not zombies in L4D (Left 4 Dead) or RE (Resident Evil). Zombies are the reanimated dead. RE pits you against people or creatures infected with the T-virus and L4D pits you against people infected with something they originally thought was just the flu but turned you into flesh eating creature.

Perhaps if influenza and rabies ever got together we could have a L4D scenario on our hands. My advice is to buy L4D and treat it as a training tool for your future survival. It is important that you get your whole family to play it even the children. They will thank you one day.


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