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The discovery of WWP2 could lead to new drug advancements within the next decade  (Source: sciencedaily.com)
Could lead to the development of new drugs for aggressive cancers within the next decade

University of East Anglia researchers may have found a way to prevent the spread of cancer through the discovery of a rogue gene. 

Andrew Chantry, study leader from the University of East Anglia's School of Biological Sciences, and Dr. Surinder Soond, of the University of East Anglia, have discovered a rogue gene that, if blocked by proper medication, could prevent the spread of cancer

The discovery of the rogue gene came about when the team of researchers was studying 'Smads,' which are natural cancer cell inhibitors in the human body. 

The rogue gene is called WWP2, and it is an enzymic bonding agent. It is found within cancer cells and helps the spread of cancer by attacking Smads in the human body, which are supposed to stop the spread of cancer. 

"The late stages of cancer involve a process known as metastasis - a critical phase in the progression of the disease that cannot currently be treated or prevented," said Chantry. "The challenge now is to identify a potent drug that will get inside cancer cells and destroy the activity of the rogue gene. This is a difficult but not impossible task, made easier by the deeper understanding of the biological processes revealed in this study."

In the lab, researchers found that the levels of the natural inhibitor increased when WWP2 was blocked. This caused the cancer cells to remain dormant. 

Chantry and Soond hope this research leads to the development of drugs that can block WWP2. This would allow Smads to prevent the spread of cancer, and doctors could perform surgery on primary tumors without worrying about the spread of the disease.  

According to Chantry, these drugs could be developed within the next decade, taking researchers one step closer to success in the war on cancer. They're aiming to stop the spread of some of the most aggressive cancers such as brain, colon, skin and breast cancer

This study was published in Oncogene.



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RE: Lets see
By geddarkstorm on 1/24/2011 2:27:23 PM , Rating: 2
Really, and what drug is that?

The FDA does a vital role. They protect us from the companies just outputting a new snake oil once a week to fleece us with empty promises before we catch on. Think of Viocodin and Percocet which slipped by the FDA and were found to be deadly later on, and thus recalled. Without the FDA at all, that would be happening constantly.

You better believe we should be slow when it comes to drugs. Unintended consequences are the RULE and the NORM not the exception with drug design. And for very good biological reasons. We are all slightly chemically different, nothing will work for everyone, and there will always be side effects. It's a matter of balancing the good above the harm, and that's what the FDA process attempts to screen.


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