Presence of Circulating Tumor Cells May Predict Relapse/Death in Breast Cancer Patients
December 27, 2010 12:44 PM
Researchers found that the more CTCs an early-stage breast cancer patient has, the higher the risk.
Researchers from the Women's Hospital at the University of Munich have discovered that the number of circulating tumor cells (CTCs) found in a patient with early-stage breast cancer may be able to predict the risk of cancer recurrence and death.
Brigitte Rack, M.D., study leader and head of the department of gynecological oncology at the Women's Hospital at the University of Munich, Germany, along with a team of researchers, believe that the risk of cancer recurrence and death increases within an early-stage breast cancer patient
if they have CTCs present
. The more CTCs they have, the higher the risk of cancer relapse and death, according to Phase III results of the SUCCESS trial.
"The CTCs might have been released from the primary tumor before these patients underwent surgery, and the expression of stem cell markers on disseminated tumor cells has been shown by several groups," said Rack.
Rack and her team chose to use CTCs as a gauge for relapse and death prediction in metastatic breast cancer patients because a CTC test has been approved by the
Food and Drug
, and previous studies have shown the effectiveness of using CTCs this way.
To test the CTCs' ability to predict such circumstances, Rack and her team studied patients with early-stage
who already had surgery, but did not have chemotherapy treatment yet. Out of 180 patients, 114 experienced cancer relapse and 66 died. Rack noted that 21.5 percent of these patients had one or more CTCs before adjuvant treatment, and were "more frequently node-positive." Patients with one to four CTCs had an 88 percent heightened risk of early breast cancer relapse and a 91 percent increased risk of death. Those with five or more CTCs had a heightened risk of recurrence by 400 percent and a 300 percent increased risk of death.
Rack and her team said being CTC-positive was an
for the chance of survival within these patients.
"Our study suggests testing CTCs may prove to be important to help individualize therapy for early-stage breast cancer where no measurable tumor is present," said Rack. "Patients who seem to be at high risk due to CTC may benefit from additional treatment options, and those who don't have CTCs may be spared
side effects of some treatments
Rack and her team plan to start trials testing this theory in Europe and the United States soon, but have not specified an exact date.
"If they're going to pirate somebody, we want it to be us rather than somebody else." -- Microsoft Business Group President Jeff Raikes
Gold-coated Liposomes Could be Used to Deliver Drugs Directly to Cancerous Tissue
December 24, 2010, 2:11 PM
Researchers Discover Possible Breast Cancer Biomarker in "Junk" DNA
December 17, 2010, 11:00 AM
Discovery Sheds New Light on How Cancer Cells Infect Healthy Tissue
December 13, 2010, 5:53 PM
Being worked to death? Study says high stress job and low job control can kill you
October 28, 2016, 4:44 AM
Birth Control Contributes to Depression in Teens and Young Women
October 26, 2016, 4:31 AM
Cyber Hackers Threaten Security of Lifesaving Medical Devices
October 19, 2016, 8:09 AM
Innovative Neurotechnology in Sound Therapy Reduces High Blood Pressure and Migraines
October 16, 2016, 5:00 AM
Researchers Move Closer to Breakthrough Gene Therapy to Cure Sickle Cell
October 14, 2016, 5:00 AM
Keytruda: A breakthrough treatment to increase survival rates for lung cancer patients
October 12, 2016, 5:00 AM
Most Popular Articles
Apple iOS Contains Secret One-handed Keyboard Code
October 22, 2016, 5:00 AM
The Unlocked Moto Z Play Launches for $449.99 Today.
October 22, 2016, 5:00 AM
The New HP Spectre: Revamped and Ready
October 23, 2016, 6:00 AM
New Way to Read Data on Ulta Hard Drives
October 23, 2016, 9:38 AM
Car Insurance - The Hidden Discriminatory Practise
October 18, 2016, 5:00 AM
Latest Blog Posts
From Time to Time, The Unbelievable and Unimaginable Happens!!!!
Oct 28, 2016, 4:56 AM
Key EpiPen Competitor Out in 2017 At ' Very Low' Cost
Oct 27, 2016, 5:30 AM
Researchers use CRISPR to Accelerate Search for HIV Cure
Oct 26, 2016, 5:00 AM
Medical Council of India Makes Generic Medicines Mandatory
Oct 25, 2016, 5:00 AM
MacBoo Pro 2016: Release date Oct. 27
Oct 24, 2016, 7:16 AM
Mac Users, Try this if Your Mac is Infected?
Oct 23, 2016, 7:00 AM
Tips to Prevent Smartphones From Overheating:
Oct 22, 2016, 5:00 AM
Nasa Flies Drones at Nevada Airport
Oct 21, 2016, 8:21 AM
T-Mobile Data Problems
Oct 20, 2016, 10:17 AM
Annoying Apple Watch Problems and How to Fix Them
Oct 20, 2016, 5:00 AM
Your Mail May Soon Be Delivered By Robot
Oct 19, 2016, 9:34 AM
2018 Jeep Wrangler Prototype Sells At Junkyard
Oct 18, 2016, 5:00 AM
Samsung Shines with Gold Edition Tablet
Oct 17, 2016, 9:24 AM
Tesla Hints Mysterious Product Debut for October 17th
Oct 16, 2016, 10:14 AM
Samsung Galaxy Note 7 Phones on US flights
Oct 15, 2016, 5:00 AM
Comcast Fined $2.3 Million For Unconfirmed Services Charged To Customers
Oct 14, 2016, 5:00 AM
“American singer / songwriter “Bob Dylan is awarded 2016 Nobel Prize in Literature.
Oct 13, 2016, 10:33 AM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information