Presence of Circulating Tumor Cells May Predict Relapse/Death in Breast Cancer Patients
December 27, 2010 12:44 PM
comment(s) - last by
Researchers found that the more CTCs an early-stage breast cancer patient has, the higher the risk.
Researchers from the Women's Hospital at the University of Munich have discovered that the number of circulating tumor cells (CTCs) found in a patient with early-stage breast cancer may be able to predict the risk of cancer recurrence and death.
Brigitte Rack, M.D., study leader and head of the department of gynecological oncology at the Women's Hospital at the University of Munich, Germany, along with a team of researchers, believe that the risk of cancer recurrence and death increases within an early-stage breast cancer patient
if they have CTCs present
. The more CTCs they have, the higher the risk of cancer relapse and death, according to Phase III results of the SUCCESS trial.
"The CTCs might have been released from the primary tumor before these patients underwent surgery, and the expression of stem cell markers on disseminated tumor cells has been shown by several groups," said Rack.
Rack and her team chose to use CTCs as a gauge for relapse and death prediction in metastatic breast cancer patients because a CTC test has been approved by the
Food and Drug
, and previous studies have shown the effectiveness of using CTCs this way.
To test the CTCs' ability to predict such circumstances, Rack and her team studied patients with early-stage
who already had surgery, but did not have chemotherapy treatment yet. Out of 180 patients, 114 experienced cancer relapse and 66 died. Rack noted that 21.5 percent of these patients had one or more CTCs before adjuvant treatment, and were "more frequently node-positive." Patients with one to four CTCs had an 88 percent heightened risk of early breast cancer relapse and a 91 percent increased risk of death. Those with five or more CTCs had a heightened risk of recurrence by 400 percent and a 300 percent increased risk of death.
Rack and her team said being CTC-positive was an
for the chance of survival within these patients.
"Our study suggests testing CTCs may prove to be important to help individualize therapy for early-stage breast cancer where no measurable tumor is present," said Rack. "Patients who seem to be at high risk due to CTC may benefit from additional treatment options, and those who don't have CTCs may be spared
side effects of some treatments
Rack and her team plan to start trials testing this theory in Europe and the United States soon, but have not specified an exact date.
This article is over a month old, voting and posting comments is disabled
RE: Nice Rack?
12/28/2010 8:30:44 AM
I searched this article for the word "rack" because I knew someone would be commenting on it.
"If they're going to pirate somebody, we want it to be us rather than somebody else." -- Microsoft Business Group President Jeff Raikes
Gold-coated Liposomes Could be Used to Deliver Drugs Directly to Cancerous Tissue
December 24, 2010, 2:11 PM
Researchers Discover Possible Breast Cancer Biomarker in "Junk" DNA
December 17, 2010, 11:00 AM
Discovery Sheds New Light on How Cancer Cells Infect Healthy Tissue
December 13, 2010, 5:53 PM
Nail Polish May Soon be Able to Detect Date Rape Drugs
August 26, 2014, 7:57 AM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
NASA Opportunity Rover Breaks Record for Most Miles Traveled on Another Planet
July 29, 2014, 1:38 PM
Most Popular Articles
Appalling Negligence: Decade-Old Windows XPe Holes Led to Home Depot Hack
September 8, 2014, 8:58 PM
iBend: Reports Grow of Razor-Thin iPhone 6+ Folding Like Origami in Your Pocket
September 23, 2014, 6:08 PM
New AT&T Mobile Share Value "Double Data" Promotion Lasts Through October
September 28, 2014, 8:32 AM
Update: Apple Releases iOS 8.0.2 Update to Make Up for Botched 8.0.1 Release
September 25, 2014, 8:19 PM
TiVo Mega Features 24TB of Storage, Can Record Three Years* Worth of TV Content
September 8, 2014, 8:45 AM
Latest Blog Posts
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information