Presence of Circulating Tumor Cells May Predict Relapse/Death in Breast Cancer Patients
December 27, 2010 12:44 PM
Researchers found that the more CTCs an early-stage breast cancer patient has, the higher the risk.
Researchers from the Women's Hospital at the University of Munich have discovered that the number of circulating tumor cells (CTCs) found in a patient with early-stage breast cancer may be able to predict the risk of cancer recurrence and death.
Brigitte Rack, M.D., study leader and head of the department of gynecological oncology at the Women's Hospital at the University of Munich, Germany, along with a team of researchers, believe that the risk of cancer recurrence and death increases within an early-stage breast cancer patient
if they have CTCs present
. The more CTCs they have, the higher the risk of cancer relapse and death, according to Phase III results of the SUCCESS trial.
"The CTCs might have been released from the primary tumor before these patients underwent surgery, and the expression of stem cell markers on disseminated tumor cells has been shown by several groups," said Rack.
Rack and her team chose to use CTCs as a gauge for relapse and death prediction in metastatic breast cancer patients because a CTC test has been approved by the
Food and Drug
, and previous studies have shown the effectiveness of using CTCs this way.
To test the CTCs' ability to predict such circumstances, Rack and her team studied patients with early-stage
who already had surgery, but did not have chemotherapy treatment yet. Out of 180 patients, 114 experienced cancer relapse and 66 died. Rack noted that 21.5 percent of these patients had one or more CTCs before adjuvant treatment, and were "more frequently node-positive." Patients with one to four CTCs had an 88 percent heightened risk of early breast cancer relapse and a 91 percent increased risk of death. Those with five or more CTCs had a heightened risk of recurrence by 400 percent and a 300 percent increased risk of death.
Rack and her team said being CTC-positive was an
for the chance of survival within these patients.
"Our study suggests testing CTCs may prove to be important to help individualize therapy for early-stage breast cancer where no measurable tumor is present," said Rack. "Patients who seem to be at high risk due to CTC may benefit from additional treatment options, and those who don't have CTCs may be spared
side effects of some treatments
Rack and her team plan to start trials testing this theory in Europe and the United States soon, but have not specified an exact date.
“So far we have not seen a single Android device that does not infringe on our patents." -- Microsoft General Counsel Brad Smith
Gold-coated Liposomes Could be Used to Deliver Drugs Directly to Cancerous Tissue
December 24, 2010, 2:11 PM
Researchers Discover Possible Breast Cancer Biomarker in "Junk" DNA
December 17, 2010, 11:00 AM
Discovery Sheds New Light on How Cancer Cells Infect Healthy Tissue
December 13, 2010, 5:53 PM
PIQ ROBOTTM reveals its new artificial intelligence software
November 29, 2016, 12:59 AM
One more time - Happy Thanksgiving to Everyone Around the World
November 24, 2016, 4:00 AM
Google’s Smart Contact Lens Project gets halted for 2016
November 20, 2016, 7:00 AM
Cell Research Study shows African Americans have greater immune response to infection
November 10, 2016, 1:00 AM
UTHealth Clinical Trial Shows Progress Using Stem Cells to Treat Traumatic Brain Injury
November 8, 2016, 1:00 AM
Uber Partners with Circulation to Pilot Program Connecting Transportation and Digital Health Care
November 6, 2016, 5:00 AM
Most Popular Articles
What Can You Do with Your New Echo Dot?
December 3, 2016, 5:00 AM
Google has developed Deep Learning Algorithm to detect Diabetic Eye Disease
December 4, 2016, 5:00 AM
Microsoft Surface – Which Surface is Right for You?
December 2, 2016, 5:00 AM
The iPlugmate is an Excellent iPhone Flash Drive at a Great Price. (Deal Expires in 3 Days)
November 23, 2016, 1:00 AM
Foscam R2 Home Security Camera System – High Quality High FHD Security Video Footage with No Monthly Fees
December 1, 2016, 2:00 AM
Latest Blog Posts
Latest Tech News
Dec 8, 2016, 5:11 AM
In The News
Dec 7, 2016, 5:00 AM
e Guide: Mobile Security for 2017
Dec 6, 2016, 5:00 AM
Apple Car is Not Dead
Dec 5, 2016, 1:00 AM
Dec 4, 2016, 5:00 AM
Dec 3, 2016, 5:00 AM
Dec 2, 2016, 5:00 AM
Surface Ergonomic Keyboard
Dec 1, 2016, 3:01 AM
Chapeconense plane crash: Football rallies around Brazilian Team
Nov 30, 2016, 1:00 AM
How to Extends Your iPhone’s Battery Life
Nov 29, 2016, 12:49 AM
Nov 28, 2016, 1:12 AM
News: Fidel Castro
Nov 27, 2016, 5:00 AM
Nov 26, 2016, 5:00 AM
Changes in Social status affect the way genes turn on and off within immune cells.
Nov 25, 2016, 5:12 AM
Austrian far–right hopeful Hofer may back EU vote.
Nov 24, 2016, 4:00 AM
Final Fantasy XV Leaked Before Nov 29 Launch Date
Nov 23, 2016, 1:00 AM
Nov 22, 2016, 2:26 AM
Nov 21, 2016, 1:00 AM
HTC Makes Big Moves in China
Nov 20, 2016, 2:00 AM
Do you know who is the number one company in the word?
Nov 19, 2016, 5:30 AM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information