ALS in Mice May be Treated with Blue-Green Algae Supplement
December 21, 2010 4:22 PM
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Mice with ALS experienced a delay in motor-related symptoms when fed a Spirulina diet
University of South Florida
researchers may have found that using a blue-green algae as a nutritional supplement for mice with amyotrophic lateral sclerosis (ALS) can help to protect and support motor neurons.
Svitlana Garbuzova-Davis, Ph.D., lead author of the study and assistant professor in the Department of Neurosurgery and Brain Repair at the University of South Florida, and Paula C. Bickford, Ph.D., co-author of the study and a professor in the Department of Neurosurgery and Brain Repair at the University of South Florida, have discovered that a specific dietary supplement with blue-green
may help delay the symptoms of ALS in mice.
The blue-green algae is called Spirulina, and it is a
that was used by the Aztecs as a food source. Spirulina, when fed to mice with ALS, may be capable of delaying the onset of ALS-related symptoms, such as motor problems and increased inflammatory markers.
"ALS is a degenerative motor neuron disease," said Garbuzova-Davis. "Most available treatments relieve symptoms without altering the underlying disease. However, evidence for oxidative stress has been associated with ALS and, in our past studies, we demonstrated potent decreases in markers of oxidative damage and inflammation in aged rats
supplemented with Spirulina or spinach. In this initial study, the diet supplement was fed only to pre-symptomatic mice. Further studies showing the diet supplement's effect on the lifespan of symptomatic ALS mice are needed to prove the treatment's effectiveness."
The University of South Florida researchers believe that Spirulina may have combined anti-inflammatory and antioxidant characteristics that support motor neurons, helping to offset the symptoms of ALS. The study shows that feeding a G93A mouse model a nutritional Spirulina diet over a 10-week period resulted in delayed disease progression and motor problems, decreased
death and the reduction of inflammatory markers.
"The focus of our future ALS experiments will include motor neuron counts and examination of lifespan following dietary Spirulina supplementation in symptomatic ALS mice," said Bickford.
was published in
The Open Tissue Engineering and Regenerative Medicine Journal
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Hard to know
12/22/2010 1:59:55 PM
Unfortunately in the ALS mouse model the disease is caused by a mutation which leads to free radical accumulation and oxidative stress and thus motor neuron death. The problem is only about 5% of human ALS cases have the same underlying cause as the mouse model so whether this would help everyone else is hard to guess.
Of the many things that are terrible about ALS - probably the worst is that in 95% of the cases we don't even know what the underlying cause is well enough to make a mouse model and start looking for treatments/preventives.
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