Testicular Tissue May be Used to Grow Insulin in Men with Type 1 Diabetes
December 13, 2010 10:05 AM
Using insulin-producing spermatogonial stem cells makes the therapy look promising
Georgetown University Medical Center (GUMC)
researchers have discovered that testicular tissue may be used to grow insulin-producing cells for men with type 1 diabetes.
G. Ian Gallicano, Ph.D., study leader and associate professor in the Department of Cell Biology at GUMC, and his team of researchers at GUMC, have found that men with type 1 diabetes could potentially
grow insulin-producing cells
with their own testicular tissue.
Up until now, other similar forms of therapy for type 1 diabetes patients have failed. For instance, researchers tried transplanting insulin-secreting islet cells from deceased patients into those with diabetes, but the body has the capability of rejecting them. In addition, researchers have used induced pluripotent stem (IPS) cells, which are adult stem cells that act like embryonic stem cells by being programmed with other types of genes, in the past to cure mice of diabetes. The problem with this therapy was that it caused teratomas, or
, in transfected tissue.
But now, Gallicano and his team have found a new stem cell therapy. They extracted human spermatogonial stem cells (SSCs) from the testicular tissue of a deceased patient, and found that these stem cells could transform into beta islet cells that secrete insulin, which are usually found
within the pancreas
. Just 1 gram of testicular tissue produced 1 million stem cells.
What makes this new process unique is that the stem cells are capable of morphing into the insulin-producing beta islet cells without the use of any extra genes, which are used in most labs to help transform stem cells into various kinds of tissue. They have the ability to transform without additional genes because SSCs already have the required genes needed to become
embryonic stem cells
"No stem cells, adult or embryonic, have been induced to secrete enough insulin yet to cure diabetes in humans, but we know SSCs have the potential to do what we want them to do, and we know how to improve their yield," said Gallicano.
Gallicano and his team have already tested this therapy on diabetic mice. They transplanted the SSCs into the backs of diabetic mice, and found that the cells produced enough insulin to decrease glucose levels for a week. The GUMC team plan to improve the therapy so that it can last longer.
This study was presented at the 50th annual meeting of the
American Society for Cell Biology
"A politician stumbles over himself... Then they pick it out. They edit it. He runs the clip, and then he makes a funny face, and the whole audience has a Pavlovian response." -- Joe Scarborough on John Stewart over Jim Cramer
Researchers Kill Cancerous Tissue with Hyperthermia
November 23, 2010, 1:53 PM
Researchers Announce First Clinical Trial for Stem Cell Therapy
October 12, 2010, 10:19 AM
Artificial Pancreas Shows Promise for Type 1 Diabetes Patients
April 18, 2010, 6:06 PM
PIQ ROBOTTM reveals its new artificial intelligence software
November 29, 2016, 12:59 AM
One more time - Happy Thanksgiving to Everyone Around the World
November 24, 2016, 4:00 AM
Google’s Smart Contact Lens Project gets halted for 2016
November 20, 2016, 7:00 AM
Cell Research Study shows African Americans have greater immune response to infection
November 10, 2016, 1:00 AM
UTHealth Clinical Trial Shows Progress Using Stem Cells to Treat Traumatic Brain Injury
November 8, 2016, 1:00 AM
Uber Partners with Circulation to Pilot Program Connecting Transportation and Digital Health Care
November 6, 2016, 5:00 AM
Most Popular Articles
Phillips 55’ 4K Smart TV – Is This Really a Deal? We Think So.
November 25, 2016, 9:44 AM
Sales Battle - Apple iPad Mini vs Samsung Galaxy Tab
November 29, 2016, 12:36 AM
Echo Dot is a Best Seller - Sold Out Until December 1, 2016.
November 26, 2016, 6:00 AM
PlayStation 4 Pro – 4K Console for 4K TVs
November 28, 2016, 1:00 AM
Star Wars Android Smartphones coming to a Japanese Galaxy Near You
November 26, 2016, 5:00 AM
Latest Blog Posts
Dec 2, 2016, 5:00 AM
Surface Ergonomic Keyboard
Dec 1, 2016, 3:01 AM
Chapeconense plane crash: Football rallies around Brazilian Team
Nov 30, 2016, 1:00 AM
How to Extends Your iPhone’s Battery Life
Nov 29, 2016, 12:49 AM
Nov 28, 2016, 1:12 AM
News: Fidel Castro
Nov 27, 2016, 5:00 AM
Nov 26, 2016, 5:00 AM
Changes in Social status affect the way genes turn on and off within immune cells.
Nov 25, 2016, 5:12 AM
Austrian far–right hopeful Hofer may back EU vote.
Nov 24, 2016, 4:00 AM
Final Fantasy XV Leaked Before Nov 29 Launch Date
Nov 23, 2016, 1:00 AM
Nov 22, 2016, 2:26 AM
Nov 21, 2016, 1:00 AM
HTC Makes Big Moves in China
Nov 20, 2016, 2:00 AM
Do you know who is the number one company in the word?
Nov 19, 2016, 5:30 AM
Foldable Cardboard ”EcoHelmet” wins James Dyson Award’s Top Prize
Nov 18, 2016, 2:39 AM
Scientists Discover Roundest Object Ever Spotted in Universe
Nov 17, 2016, 1:00 AM
Smallest Device Lets You Print Almost from Anywhere
Nov 16, 2016, 9:32 AM
Cancer Screening in the Community Is there a link between Cancer and Poverty?
Nov 15, 2016, 8:00 AM
Points to Consider when Buying Your New PC – Window 10 PC Buying Guide
Nov 14, 2016, 5:00 AM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information