Testicular Tissue May be Used to Grow Insulin in Men with Type 1 Diabetes
December 13, 2010 10:05 AM
comment(s) - last by
Using insulin-producing spermatogonial stem cells makes the therapy look promising
Georgetown University Medical Center (GUMC)
researchers have discovered that testicular tissue may be used to grow insulin-producing cells for men with type 1 diabetes.
G. Ian Gallicano, Ph.D., study leader and associate professor in the Department of Cell Biology at GUMC, and his team of researchers at GUMC, have found that men with type 1 diabetes could potentially
grow insulin-producing cells
with their own testicular tissue.
Up until now, other similar forms of therapy for type 1 diabetes patients have failed. For instance, researchers tried transplanting insulin-secreting islet cells from deceased patients into those with diabetes, but the body has the capability of rejecting them. In addition, researchers have used induced pluripotent stem (IPS) cells, which are adult stem cells that act like embryonic stem cells by being programmed with other types of genes, in the past to cure mice of diabetes. The problem with this therapy was that it caused teratomas, or
, in transfected tissue.
But now, Gallicano and his team have found a new stem cell therapy. They extracted human spermatogonial stem cells (SSCs) from the testicular tissue of a deceased patient, and found that these stem cells could transform into beta islet cells that secrete insulin, which are usually found
within the pancreas
. Just 1 gram of testicular tissue produced 1 million stem cells.
What makes this new process unique is that the stem cells are capable of morphing into the insulin-producing beta islet cells without the use of any extra genes, which are used in most labs to help transform stem cells into various kinds of tissue. They have the ability to transform without additional genes because SSCs already have the required genes needed to become
embryonic stem cells
"No stem cells, adult or embryonic, have been induced to secrete enough insulin yet to cure diabetes in humans, but we know SSCs have the potential to do what we want them to do, and we know how to improve their yield," said Gallicano.
Gallicano and his team have already tested this therapy on diabetic mice. They transplanted the SSCs into the backs of diabetic mice, and found that the cells produced enough insulin to decrease glucose levels for a week. The GUMC team plan to improve the therapy so that it can last longer.
This study was presented at the 50th annual meeting of the
American Society for Cell Biology
This article is over a month old, voting and posting comments is disabled
12/13/2010 11:48:23 AM
I hope that they can find a solution for the type 1 diabetes.
I have type 1 aswell. And although I can live like a normal person. The annoying thing is that I can't work properly because of bloodsugar shifting up and down.
I would seriously give up my balls for that. I'm a diabetic for over 10 years, and it really is starting to nag me.
I have to think about everything I do or eat. My freedom is basically gone.
I hope they keep up the good work ;)
I have been reading a lot of articles about the Isle's transplantation and all that. But this really looks promising.
Diabetes is a nasty thing I can tell. It's not pleasant at all when you can't eat what you normally can. And you can't do something, someone else can.
Atleast I have a bit of hope again.
Diabetes has been on the scene for a long time. It's time to get rid of it and help a lot of people.
"My sex life is pretty good" -- Steve Jobs' random musings during the 2010 D8 conference
Researchers Kill Cancerous Tissue with Hyperthermia
November 23, 2010, 1:53 PM
Researchers Announce First Clinical Trial for Stem Cell Therapy
October 12, 2010, 10:19 AM
Artificial Pancreas Shows Promise for Type 1 Diabetes Patients
April 18, 2010, 6:06 PM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information