Testicular Tissue May be Used to Grow Insulin in Men with Type 1 Diabetes
December 13, 2010 10:05 AM
comment(s) - last by
Using insulin-producing spermatogonial stem cells makes the therapy look promising
Georgetown University Medical Center (GUMC)
researchers have discovered that testicular tissue may be used to grow insulin-producing cells for men with type 1 diabetes.
G. Ian Gallicano, Ph.D., study leader and associate professor in the Department of Cell Biology at GUMC, and his team of researchers at GUMC, have found that men with type 1 diabetes could potentially
grow insulin-producing cells
with their own testicular tissue.
Up until now, other similar forms of therapy for type 1 diabetes patients have failed. For instance, researchers tried transplanting insulin-secreting islet cells from deceased patients into those with diabetes, but the body has the capability of rejecting them. In addition, researchers have used induced pluripotent stem (IPS) cells, which are adult stem cells that act like embryonic stem cells by being programmed with other types of genes, in the past to cure mice of diabetes. The problem with this therapy was that it caused teratomas, or
, in transfected tissue.
But now, Gallicano and his team have found a new stem cell therapy. They extracted human spermatogonial stem cells (SSCs) from the testicular tissue of a deceased patient, and found that these stem cells could transform into beta islet cells that secrete insulin, which are usually found
within the pancreas
. Just 1 gram of testicular tissue produced 1 million stem cells.
What makes this new process unique is that the stem cells are capable of morphing into the insulin-producing beta islet cells without the use of any extra genes, which are used in most labs to help transform stem cells into various kinds of tissue. They have the ability to transform without additional genes because SSCs already have the required genes needed to become
embryonic stem cells
"No stem cells, adult or embryonic, have been induced to secrete enough insulin yet to cure diabetes in humans, but we know SSCs have the potential to do what we want them to do, and we know how to improve their yield," said Gallicano.
Gallicano and his team have already tested this therapy on diabetic mice. They transplanted the SSCs into the backs of diabetic mice, and found that the cells produced enough insulin to decrease glucose levels for a week. The GUMC team plan to improve the therapy so that it can last longer.
This study was presented at the 50th annual meeting of the
American Society for Cell Biology
This article is over a month old, voting and posting comments is disabled
Imagine what the scientists told their collegues...
12/13/2010 11:12:44 AM
"What are you working on?"
"I'm seeing what beneficial properties we can milk from sperm. I think we can cure Type-1 diabetes, make the blind see, and increase the protein intake for people with deficiencies."
heh. But really "probably" "may be" "potentially" are some key words in the article I'm not too fond of seeing. I just really hope that they make some solid proof that they can help people with Type-1 and finally have for them something other than an insulin injection and testing blood sugar regularly.
"If you mod me down, I will become more insightful than you can possibly imagine." -- Slashdot
Did You Partake in "Black Friday/Thursday"?
Did You Partake in "Black Friday/Thursday"?
I skipped Thanksgiving to get the Black Thursday deals!
I spent Thanksgiving with friends/family, but I lined up at midnight for the deals!
Skip Thanksgiving? Wait in line? No way, but I'll go out today and see what's left.
I prefer Cyber Monday.
I don't do deal shopping... too much stress, it just isn't worth it.
Researchers Kill Cancerous Tissue with Hyperthermia
November 23, 2010, 1:53 PM
Researchers Announce First Clinical Trial for Stem Cell Therapy
October 12, 2010, 10:19 AM
Artificial Pancreas Shows Promise for Type 1 Diabetes Patients
April 18, 2010, 6:06 PM
Some Dark Side For Your Black Friday: Official Star Wars Ep. VII Trailer Lands
November 28, 2014, 1:02 PM
U.S. Air Force F-35 Lightning II, F-22 Raptor Team Up for “Integration Training”
November 19, 2014, 9:15 AM
U.S. Marshals Using Fake, Airplane-based Cell Towers to Scan Cell Phones of Americans
November 14, 2014, 9:05 AM
Ford Enlists Wind Energy Corp. to Provide Wind, Solar Energy to Four U.S. Dealerships
November 10, 2014, 10:58 AM
Disney Reveals Star Wars Ep. VII Title -- "The Force Awakens"
November 6, 2014, 3:45 PM
U.S. Navy Lockheed F-35C Completes First Carrier Landing
November 4, 2014, 12:44 PM
Most Popular Articles
Hack of Sony Pictures Indicates Employees Were Pirating Blu-Rays
November 25, 2014, 4:00 PM
Google Caves to Microsoft and Apple's Pet "Patent Troll" Rockstar
November 24, 2014, 3:30 PM
Some High-End Luxury Watchmakers Crack Down Hard on Smartwatch Faces
November 26, 2014, 1:28 AM
Report: Samsung Galaxy S5 Sales Have Come in 40% Below Projections
November 24, 2014, 6:58 AM
Xiaomi Aims to be #1 Smartphone OEM Within 10 Years, Apple Urges Caution
November 21, 2014, 9:33 AM
Latest Blog Posts
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information