Researchers Create Mouse With Two Fathers, Say Humans Could be Next
December 9, 2010 11:43 AM
comment(s) - last by
Scientists have created mice with two fathers. A surrogate mother is required, but her DNA isn't passed to the selected offspring..
(Source: Science Museum)
The laws of nature are being seriously bent by this Texas team
Two male mammals can not reproduce with each other, right? That's what you learned in your biology class, certainly. Well turns out, like many laws of nature, there can be exceptions, with a certain amount of trickery. Researchers at the
M.D. Anderson Cancer Center
in Houston, Texas have bent the rules of mammalian biology and created a pair of mice, one male one female, that have two fathers and no maternal sex chromosomes.
The MDACC team of reproductive biologists, led by
Dr. Richard R. Berhringer
first took fibroblasts (connective tissue cells) from the first male (XY) father mouse, when he was just a fetus. The fibroblasts were selected as they are easy to
induce into pluripotency
, a method of producing non-embryonic stem cells. The induced pluripotent stem cells (iPSCs) were then cultured.
During the culturing something funny happened -- the Y allele disappeared in some of the cells. This proved a critical step in producing two-father babies. The XO cells were then transplanted into the blastocyst (developing embryo) of a mouse surrogate mother. The resulting female chimera children (a second surrogate mother), which had a mix of XO/XX sex chromosomes. The females (which bore the paternal chromesome from the first father) were then mated with the second father.
The end result of this rather confusing process was that some of the children had sex chromosomes from both fathers, or both mothers. They also likely inherited autosomes from each father.
The team proclaims, "Our study exploits iPS cell technologies to combine the alleles from two males to generate male and female progeny, i.e. a new form of mammalian reproduction."
The researchers speculate that they could also use the technique to get the mouse to self reproduce. They state, "It is also possible that one male could produce both oocytes and sperm for self-fertilization to generate male and female progeny."
the work in the journal
Biology of Reproduction
They say that it could be leveraged to save
. If only two males were in captivity, a surrogate mother of a similar species could be used to birth a Chimera which would produce oocytes (eggs) from the first father, resulting in two fathers being able to pass their genetic legacy on to offspring.
Applications may also lie in livestock breeding. Typically livestock are selected for favorable characteristics. But what if two males
have certain very favorable genetic traits? This technique could allow those strengths to be merged.
Last, but not least, the team's most controversial suggestion is that using a varied iPS technique, human oocytes (eggs) could be produced from a father's cells. This could lead to two men being able to synthetically reproduce, certainly a controversial technology. The only question left is whether two females could be made to reproduce as well? We'll have to wait and see for future studies on that topic.
This article is over a month old, voting and posting comments is disabled
12/9/2010 12:28:02 PM
Maybe the only way that college tuition could be paid for in twenty years. Have two fathers paying child support.
12/9/2010 1:36:24 PM
Feel bad for the young lad who starts dating the daughter of a dual dad. Good cop/bad cop to the extreme.
PS - Thats assuming the daughter is into men. Guess either way is double shotgun potential.
"If they're going to pirate somebody, we want it to be us rather than somebody else." -- Microsoft Business Group President Jeff Raikes
Report: Tigers Near Extinction, Only 3,200 Left as Poaching Continues
February 11, 2010, 4:12 PM
Researchers Make Leap in Stem Cell Research; Cells Can Now be Produced From Any Tissue
July 2, 2008, 10:03 AM
Swarm of GMO Mosquitoes Set to Fly in South Florida
January 27, 2015, 6:40 PM
Crowdfunded Sex Toy Lets You Control the Action From Your Wii Nunchuk
January 15, 2015, 3:42 PM
Elon Musk Plays Warcraft; But Still Finds Time to Sleep, Build a Mars Colony Ship
January 6, 2015, 9:54 PM
SpaceX Scrubs Falcon 9 Launch to ISS, Barge Landing Test, Friday Redo Targeted
January 6, 2015, 4:02 PM
Quick Note; Wreckage of Malaysian-Owned Passenger Jet Found
December 30, 2014, 12:42 PM
Quick Note: Drone Loses Fight to the Death With Kangaroo
December 23, 2014, 3:28 PM
Most Popular Articles
Under the Hood: How DirectX 11.3 and 12 Will Supercharge Windows 10 Gaming
January 23, 2015, 12:34 PM
Microsoft Shows Off Latest Windows 10 Build, Preps it for Next Week Release
January 21, 2015, 2:57 PM
BlackBerry CEO Claims Devs are Violating Net Neutrality by Not Supporting BB10
January 22, 2015, 4:37 PM
2016 Cadillac CTS-V Packs 640 hp Punch with 200 mph Reach
January 23, 2015, 3:25 PM
Will Google Become America's Fifth Major Carrier?
January 22, 2015, 12:42 PM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2015 DailyTech LLC. -
Terms, Conditions & Privacy Information