New Compound Could Protect Brain Cells, Fight Neurodegenerative Diseases
December 8, 2010 10:09 AM
comment(s) - last by
Edward R. Biehl, co-discoverer of the HSB-13 compound
HSB-13 compound could halt diseases like Alzheimer's, Huntington's and Parkinson's
Southern Methodist University (SMU)
University of Texas at Dallas
researchers have found hope for those suffering from diseases like Alzheimer's, Parkinson's and Huntington's through the discovery of
a group of molecules
which could help protect the brain.
Edward R. Biehl, study leader and a synthetic organic chemist at SMU, and Santosh R. D'Mello, co-author of the study and a biology professor at UT Dallas, have developed the compounds in an effort to halt the onset of nerve-degenerative diseases and relieve symptoms.
Alzheimer's, Parkinson's and and Huntington's are neurodegenerative diseases in the central nervous system, and afflict more than five million Americans (mainly senior citizens). These diseases are caused by the immoderate loss of neurons in an area of the mid-brain, which leads to a decline in motor skills, such as walking and speaking, as well as
and behavior problems.
Previous treatments cannot halt or reverse these types of nerve-degenerative diseases. They only relieve symptoms, and sometimes even fail at that due to the severe side effects of these medications.
But now, Biehl and D'Mello have worked together to develop compounds that could potentially protect the brain from nerve-degenerative diseases. They came upon this discovery when developing synthetic chemicals that contained a class of heterocyclic organic compounds. One particular compound in the heterocyclic class proved to be
protective of neurons
in tissue culture models. Furthermore, this same compound, named HSB-13, has also proven to be effective in fighting neurodegenerative diseases in animal models.
"Our compounds protect against neurodegeneration in mice," said Biehl. "Given successful development of the compounds into drug therapies, they would serve as an effective treatment for patients with degenerative brain diseases."
HSB-13 not only decreased degeneration in the forebrain, but also corrected
. It has also proved to be nontoxic while remaining "extremely potent."
Biotechnology and therapeutics company EncephRx, which is based in Dallas, is looking to create drug therapies based on this new class of compounds. The company was granted worldwide license to the "jointly owned compounds," and when the research is complete, EncephRx's pharmaceuticals made of these small compounds will be the first therapeutic tools capable of protecting brain cells and keeping them from dying.
"Additional research needs to be done, but these compounds have the potential for stopping or slowing the relentless loss of brain cells in diseases such as
and Parkinson's," said D'Mello. "The protective effect that they display in tissue culture and animal models of neurodegenerative disease provides strong evidence of their promise as drugs to treat neurodegenerative disorders."
was published in the
Journal of Neuroscience Research
This article is over a month old, voting and posting comments is disabled
RE: I'm curious about a few things...
12/9/2010 8:34:47 AM
Theoretically we can test all of these things:
a. Detect protein binding via a FRET-like system (google FRET), yeast two-hybrid, GST pulldown, etc. If the small molecule makes elimination easier, you could also track the protein itself via renal or bile secretions. You could of course radiolabel the small molecule and trace where it goes.
b. Again, radiolabel it to see where it goes. Track metabolism and elimination. Determine if inhibition of the hypothetical neuron-small molecule interaction disrupts the efficacy.
Am I just nerdy, or is he holding a reagant bottle from Fisher Scientific (probably a salt of some kind) and standing behind a GC-FID readout with a solvent peak (probably ethanol or acetone or something of that sort)?
"If you can find a PS3 anywhere in North America that's been on shelves for more than five minutes, I'll give you 1,200 bucks for it." -- SCEA President Jack Tretton
Study: Prenatal Cell Phone Exposure May Lead to Childhood Behavioral Problems
December 7, 2010, 10:27 AM
Nerve Toxins Destroyed by Plant-Derived Bioscavenging Molecules
November 25, 2010, 10:01 AM
Studies Yield Insight Into How Human Memory Works
January 31, 2009, 12:19 PM
Scientists Find Brain Cell Suicide May Be Alzheimer's Culprit
December 12, 2008, 8:50 AM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information