New Compound Could Protect Brain Cells, Fight Neurodegenerative Diseases
December 8, 2010 10:09 AM
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Edward R. Biehl, co-discoverer of the HSB-13 compound
HSB-13 compound could halt diseases like Alzheimer's, Huntington's and Parkinson's
Southern Methodist University (SMU)
University of Texas at Dallas
researchers have found hope for those suffering from diseases like Alzheimer's, Parkinson's and Huntington's through the discovery of
a group of molecules
which could help protect the brain.
Edward R. Biehl, study leader and a synthetic organic chemist at SMU, and Santosh R. D'Mello, co-author of the study and a biology professor at UT Dallas, have developed the compounds in an effort to halt the onset of nerve-degenerative diseases and relieve symptoms.
Alzheimer's, Parkinson's and and Huntington's are neurodegenerative diseases in the central nervous system, and afflict more than five million Americans (mainly senior citizens). These diseases are caused by the immoderate loss of neurons in an area of the mid-brain, which leads to a decline in motor skills, such as walking and speaking, as well as
and behavior problems.
Previous treatments cannot halt or reverse these types of nerve-degenerative diseases. They only relieve symptoms, and sometimes even fail at that due to the severe side effects of these medications.
But now, Biehl and D'Mello have worked together to develop compounds that could potentially protect the brain from nerve-degenerative diseases. They came upon this discovery when developing synthetic chemicals that contained a class of heterocyclic organic compounds. One particular compound in the heterocyclic class proved to be
protective of neurons
in tissue culture models. Furthermore, this same compound, named HSB-13, has also proven to be effective in fighting neurodegenerative diseases in animal models.
"Our compounds protect against neurodegeneration in mice," said Biehl. "Given successful development of the compounds into drug therapies, they would serve as an effective treatment for patients with degenerative brain diseases."
HSB-13 not only decreased degeneration in the forebrain, but also corrected
. It has also proved to be nontoxic while remaining "extremely potent."
Biotechnology and therapeutics company EncephRx, which is based in Dallas, is looking to create drug therapies based on this new class of compounds. The company was granted worldwide license to the "jointly owned compounds," and when the research is complete, EncephRx's pharmaceuticals made of these small compounds will be the first therapeutic tools capable of protecting brain cells and keeping them from dying.
"Additional research needs to be done, but these compounds have the potential for stopping or slowing the relentless loss of brain cells in diseases such as
and Parkinson's," said D'Mello. "The protective effect that they display in tissue culture and animal models of neurodegenerative disease provides strong evidence of their promise as drugs to treat neurodegenerative disorders."
was published in the
Journal of Neuroscience Research
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RE: I'm curious about a few things...
12/8/2010 1:18:28 PM
Well, this may have nothing to do with prions. In fact, most research suggests that it's the immune system that is responsible for the neural degeneration of these three diseases. Each triggers the inflammation response differently, but once it starts, and macrophages invade the brain, that's the point when neurons start to die and degeneration occurs. Many modulators of the immune system can completely block these diseases, they just also happen to be totally impractical and toxic in the long run.
Rampamycin is a nice example, even extends life span significantly... by turning off the immune system.
Now, what these compounds could be doing, is preventing the signaling of the immune invasion into the brain. There have been other compounds that can do this, and protect from neural degeneration, they just aren't very potent and have problems with the blood brain barrier. What is sounds like, is these new compounds have overcome those technicalities and may even be far more potent.
Now, this is just one hypothesis, and yours are just as valid. It'll be very interesting to find out how exactly these compounds are causing the protection. Might even be via stimulation of neurogenesis for all we know.
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