New Compound Could Protect Brain Cells, Fight Neurodegenerative Diseases
December 8, 2010 10:09 AM
comment(s) - last by
Edward R. Biehl, co-discoverer of the HSB-13 compound
HSB-13 compound could halt diseases like Alzheimer's, Huntington's and Parkinson's
Southern Methodist University (SMU)
University of Texas at Dallas
researchers have found hope for those suffering from diseases like Alzheimer's, Parkinson's and Huntington's through the discovery of
a group of molecules
which could help protect the brain.
Edward R. Biehl, study leader and a synthetic organic chemist at SMU, and Santosh R. D'Mello, co-author of the study and a biology professor at UT Dallas, have developed the compounds in an effort to halt the onset of nerve-degenerative diseases and relieve symptoms.
Alzheimer's, Parkinson's and and Huntington's are neurodegenerative diseases in the central nervous system, and afflict more than five million Americans (mainly senior citizens). These diseases are caused by the immoderate loss of neurons in an area of the mid-brain, which leads to a decline in motor skills, such as walking and speaking, as well as
and behavior problems.
Previous treatments cannot halt or reverse these types of nerve-degenerative diseases. They only relieve symptoms, and sometimes even fail at that due to the severe side effects of these medications.
But now, Biehl and D'Mello have worked together to develop compounds that could potentially protect the brain from nerve-degenerative diseases. They came upon this discovery when developing synthetic chemicals that contained a class of heterocyclic organic compounds. One particular compound in the heterocyclic class proved to be
protective of neurons
in tissue culture models. Furthermore, this same compound, named HSB-13, has also proven to be effective in fighting neurodegenerative diseases in animal models.
"Our compounds protect against neurodegeneration in mice," said Biehl. "Given successful development of the compounds into drug therapies, they would serve as an effective treatment for patients with degenerative brain diseases."
HSB-13 not only decreased degeneration in the forebrain, but also corrected
. It has also proved to be nontoxic while remaining "extremely potent."
Biotechnology and therapeutics company EncephRx, which is based in Dallas, is looking to create drug therapies based on this new class of compounds. The company was granted worldwide license to the "jointly owned compounds," and when the research is complete, EncephRx's pharmaceuticals made of these small compounds will be the first therapeutic tools capable of protecting brain cells and keeping them from dying.
"Additional research needs to be done, but these compounds have the potential for stopping or slowing the relentless loss of brain cells in diseases such as
and Parkinson's," said D'Mello. "The protective effect that they display in tissue culture and animal models of neurodegenerative disease provides strong evidence of their promise as drugs to treat neurodegenerative disorders."
was published in the
Journal of Neuroscience Research
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RE: I'm curious about a few things...
12/8/2010 1:10:19 PM
Well, really, as I understand it, prions gain entry via the celluar wall into neurons and then through some process of division, they encourage the cell to generate new prions and via protein conversion within the cell. The cell then either vacuolizes or dies and releases the produced prions, which then set out to invade other cells.
So with b., what I'm wondering is if the compound forms an additional layer on the outside of the cell wall blocking the proteins before they gain entry through the cell membrane into the cell.
The only problem with b. is that it insinuates the compound sticks around over time.
RE: I'm curious about a few things...
12/8/2010 1:27:00 PM
The prion state that causes disease is an alternate 3D conformation of the natural prion protein. It just so happens, a prion protein in this alternate state can then catalyze the conversion of a normal prion also into this state.
The converted prions then stack into a filament, and it's this filamentous bundle that eventually leads to cellular dysfunction and death. This is very similar to how the AB plagues work that contribute to Alzheimer's. How exactly the filaments damage cells is unknown, though inflammation is triggered and inflammation is highly damaging to cells caught in it (part of the point of inflammation).
What natural prions do, may be related to ion balance, but it is rather unknown. Still, they are likely not the culprits behind these three diseases; and actual prion disease (Mad Cow Disease), has a very different phenotype, both on cognitive degeneration and in the pattern of how the cells die.
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