New Tissue-imaging Technique Faster, More Accurate than Biopsies
November 29, 2010 7:08 AM
comment(s) - last by
Stephen A. Boppart and his research team
(Source: L. Brian Stauffer)
NIVI technique can process results in five minutes or less with 99 percent accuracy
Researchers from the
University of Illinois
have created a new tissue-imaging technique that is easy to read, accurate, quick and could eliminate the need for invasive biopsies.
Stephen A. Boppart, study leader and physician at the University of Illinois, has developed a microscopy
capable of providing easy-to-read results, and is also much faster than biopsy results.
Current diagnostic methods can take more than 24 hours to receive results. In addition, these tests are based on interpretations of cell structure and shape, meaning this type of testing is subjective. This type of testing requires the tissue in question to be drawn from the patient, and then mixed with a stain to make the cells easier to see. Then, under a microscope, the cells are observed and visually interpreted as either healthy or cancerous.
But the new technique, called nonlinear interferometric vibrational imaging (NIVI), offers color-coded images of tissues that
highlight tumor boundaries
clearly, making the test 99 percent accurate. Another major benefit is that results are generated in five minutes or less.
What makes NIVI so accurate is the way it assesses images. While current diagnostic methods concentrate on tissue and cell structure, NIVI builds images based on molecular composition. Researchers are able to distinguish healthy from cancerous cells easily because healthy cells have high concentrations of lipids while
produce greater amounts of protein.
NIVI uses two beams of light to excite molecules in the tissue because each molecule has a different vibrational state of energy, and when the resonance of this vibration is altered, it can send a signal which can be used to differentiate cells with high concentrations of that molecule.
"The analogy is like pushing someone on a swing," said Boppart. "If you push at the right time point, the person on the swing will go higher and higher. If you don't push at the right point in the swing, the person stops. If we use the right optical frequencies to excite these vibrational states, we can enhance the resonance and the signal."
NIVI is able to eliminate background noise and isolate the molecular signal by using one beam as a reference and joining it with the signal created by the excited tissue sample. Then a statistical analysis of the "resulting spectrum" is performed, and a color-coded image is created at eah point in the tissue where red indicates cancer cells and blue indicates healthy cells. This red-blue color coding provides an uncertain boundary zone of 100 microns, which is only a cell or two, where current diagnostic methods have a margin of uncertainty that spans a large area of tissue, leaving them in the dark when trying to identify healthy from cancerous cell shapes.
"As we get better spectral resolution and broader spectral range, we can have more flexibility in identifying different molecules," said Boppart. "Once you get to that point, we think it will have many different applications for cancer diagnostics, for optical biopsies and other types of diagnostics."
will be published in
on December 1.
This article is over a month old, voting and posting comments is disabled
11/29/2010 8:02:34 AM
Add this to a hand held array along with recent other articles on dailytech and the tricorder is complete.
"If they're going to pirate somebody, we want it to be us rather than somebody else." -- Microsoft Business Group President Jeff Raikes
New Microfluidic Device Helps Identify and Capture Breast Cancer Cells
September 29, 2010, 11:21 AM
Breastlight Could Help Find Early Signs of Breast Cancer
June 11, 2009, 8:27 AM
New MRI Technique Promises Thousands Of Times More Sensitivity
May 9, 2008, 12:16 PM
Nail Polish May Soon be Able to Detect Date Rape Drugs
August 26, 2014, 7:57 AM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
NASA Opportunity Rover Breaks Record for Most Miles Traveled on Another Planet
July 29, 2014, 1:38 PM
Most Popular Articles
Appalling Negligence: Decade-Old Windows XPe Holes Led to Home Depot Hack
September 8, 2014, 8:58 PM
iBend: Reports Grow of Razor-Thin iPhone 6+ Folding Like Origami in Your Pocket
September 23, 2014, 6:08 PM
New AT&T Mobile Share Value "Double Data" Promotion Lasts Through October
September 28, 2014, 8:32 AM
Update: Apple Releases iOS 8.0.2 Update to Make Up for Botched 8.0.1 Release
September 25, 2014, 8:19 PM
FBI Outraged That Apple, Google are Adopting Digital "Locks" to Protect Users
September 26, 2014, 1:00 PM
Latest Blog Posts
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information