Environmental Toxin "Acrolein" May Help Cause Multiple Sclerosis
November 24, 2010 2:00 PM
comment(s) - last by
(Source: Purdue University graphic/Michel Schweinsberg)
Researchers use hydralazine to counter it
have discovered that an
may aid in the cause of multiple sclerosis.
The study's lead researcher is Riyi Shi, a medical doctor and professor of neuroscience and biomedical engineering in Purdue University's Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research and Weldon School of Biomedical Engineering. Shi and his team of researchers have found that a certain environmental toxin could be held partially responsible for causing multiple sclerosis (MS).
The toxin, acrolein, is found in
like auto exhaust and tobacco
. It is also created inside the body when nerve cells are damaged.
Nerve cells are insulated with myelin, and when a person has MS, the myelin is dismantled and the nerve fibers are damaged. Researchers believe acrolein is responsible for the dismantling of the myelin as well as inducing the creation of free radicals, which are compounds that cause further injury to tissues that are already damaged due to trauma or disease.
"Only recently have researchers started to understand the details about what acrolein does to the human body," said Shi. "We are studying its effects on the central nervous system, both in trauma and degenerative diseases such as multiple sclerosis."
To see if the researchers were correct about acrolein's effects, Shi and his team of researchers used a disease much like MS to elevate the acrolein in the spinal cord tissues of mice by nearly 60 percent.
To neutralize acrolein and temporarily halt the onset of MS, Shi used the drug hydralazine, which is an FDA-approved medication normally used to treat hypertension. Previous studies conducted by Shi and his team have shown that hydralazine prevents acrolein from causing
For this particular study, researchers concluded that a connection existed between acrolein and MS because the elevated acrolein levels within the mice were reduced by 50 percent when given hydralazine. According to Shi, this study is the first concrete laboratory evidence showing a link between acrolein and MS.
"The treatment did not cause any serious side effects in the mice," said Shi. "The dosage we used for hydralazine in animals is several times lower than the standard dosing for oral hydralazine in human pediatric patients. Therefore, considering the effectiveness of hydralazine at binding acrolein at such low concentrations, we expect that our study will lead to the development of new neuroprotective
therapies for MS
that could be rapidly translated into the clinic."
In addition, the researchers have also discovered the specific chemical signature of hydralazine, which could lead to synthetic alternatives with less side effects.
The abstract can be found
This article is over a month old, voting and posting comments is disabled
RE: I Call BS On This.
11/25/2010 5:02:22 PM
Prepare to be downvoted for actually having something relevant to say.
Meanwhile, cool work. Although I'm left scratching my head on why we would need to synthesize potato flavor. Isn't that a pretty bland flavor, and isn't there enough of it in potatoes already? (showing my naivety about the food industry?)
I note with interest that these researchers are gladly finding something they can produce a magic pill for, and even perhaps an enhanced synthetic magic pill. Pharmaceutical industry funding must be a nice gig. I suggest they don't want to hear your story of real world exposure, and it's apparent lack of ill effect. And I've little doubt that tobacco and exhaust are more palatable evils than food flavorings (or their precursors).
“And I don't know why [Apple is] acting like it’s superior. I don't even get it. What are they trying to say?” -- Bill Gates on the Mac ads
New Virtual Reality Systems Assess Effects of Brain Injury/Disease on Body Function
November 15, 2010, 5:58 PM
Motor Neurone Disease Biomarker Discovered
November 5, 2010, 12:03 PM
Eastern China Has Poorest Air Quality in the World
September 28, 2010, 2:03 PM
Pre-Production Chevy Volt Hits the Streets
June 26, 2009, 9:35 AM
Cool Science Video of the Day: Carnivorous Leech Eats Giant Jungle Worm
October 16, 2014, 6:44 PM
Facebook CEO and Founder, Mark Zuckerberg, Donates $25M to Fight Ebola
October 14, 2014, 5:06 PM
Chagrined Over Leaks, CDC Confirms First U.S. Ebola Diagnosis in Dallas, Texas
September 30, 2014, 5:55 PM
Nail Polish May Soon be Able to Detect Date Rape Drugs
August 26, 2014, 7:57 AM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
Most Popular Articles
Google Launches "Same-day Delivery" Subscription Service for $95/year
October 14, 2014, 10:37 AM
Ireland to Close Loophole Apple and Google Used to Evade EU Taxes
October 13, 2014, 10:45 PM
Report: Next Generation iPad Air, iPad mini to Receive A8X with 2GB of RAM
October 13, 2014, 5:01 PM
Google Announces Android 5.0 “Lollipop”, Nexus 9 Tablet, and Nexus 6 “Phablet”
October 15, 2014, 12:41 PM
FBI Director: Don't Trust Government, But Give It Your Data Without Transparency
October 13, 2014, 7:20 PM
Latest Blog Posts
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information