Cell-depleted Lung Tissue a Matrix for New Rat Lung Using Stem Cells
August 20, 2010 2:41 PM
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(Source: Becoming Domestic)
Development and growth of new tissue proves to be successful
Researchers have released a new report showing the first successful
use of cell-depleted lung
in order to naturally create a new
from embryonic stem cells.
Joaquin Cortiella, MD, MPH, along with his research team members from Stanford University, University of Texas Medical Branch, Duke University and Brown Medical School, published their findings, a paper titled
"Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem
Cell Differentiation and Tissue Formation"
, Part A.
Most cell and tissue types can be made and matured from embryonic
(ESC's) as long as they're in the proper setting with appropriate chemical signals that allow them to differentiate into certain cell types, eventually constructing 3-dimensional tissue structures. But other forms of synthetic tissue matrices are now required in order for this kind of technology to flourish.
"Organ-specific extracellular matrices, properly prepared, are serving more and more as the appropriate structural scaffold for the recapitulation of a specific organ's tissues," said Peter C. Johnson, MD, Vice President of Research and Development for Avery Medical Products, and Co-Editor-in-Chief of
"This turns out to be especially true in an organ such as the lung, whose parenchyma must have a structure that accommodates atmospheric gas transmission as well as
, lymphatic and neural systems."
Cellular components were removed from natural lung tissue in order to make the natural growth matrix for ESC's. Making and
using an acellular rat lung
as a biological matrix "for differentiating ESC's into lung tissue" provided evidence of repopulation of the matrix, improved cell retention and differentiation into specific cell types within the lung. In addition, the development and maturation of of the cells into 3-dimensional complex tissues were reported, and according to researchers, lung tissue growth is progressing normally and is producing the correct chemical signals to continue development.
"We found that a combination of mechanical, enzymatic and physical processes provided the most efficient and gentle way to remove the cells from the underlying lung ECM without significant loss of collagen or elastin, the major components of the natural lung," the authors wrote. "The production and use of decellularized lung to support development of lung tissue may lead to design of better synthetic matrices for clinical use and to the eventual production of engineered lung tissues on matrices that are suitable for regenerative medicine purposes."
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RE: Woo Hoo!
8/22/2010 10:29:44 AM
Please get out of your hole...It's too much! Stop fucking your cousin, stop polishing your muscle cars, stop listening to Rush Limbaugh...Please educate yourself... I can't stand you anymore. You are so a stereotype of a redneck that you're not fun anymore. STOP IT
RE: Woo Hoo!
8/22/2010 10:13:43 PM
Great argument there. Even if I was a redneck, I'd keep being one just to piss you off.
I love it how idiots like yourself view anyone who's against your point of view as an uneducated redneck. But thats what happens when people watch Chris Matthews or Rachel Madcow or Keith Olbermann too much.
And I like polishing my muscle car. So fuck off. Nor do I listen to Rush Limbaugh.
RE: Woo Hoo!
8/23/2010 2:23:27 AM
So fuck off
Great argument there.
And the lunatics you mentioned, did they exists before the likes of Murdoch and his multi-million dollar propaganda campaign, or after?
Oh, your status symbol/penis extrender is rusting, deal with it.
RE: Woo Hoo!
8/23/2010 10:33:30 AM
You guys seem perfectly content to argue everything except the point.
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