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  (Source: Becoming Domestic)
Development and growth of new tissue proves to be successful

Researchers have released a new report showing the first successful use of cell-depleted lung in order to naturally create a new rat lung from embryonic stem cells.  

Joaquin Cortiella, MD, MPH, along with his research team members from Stanford University, University of Texas Medical Branch, Duke University and Brown Medical School, published their findings, a paper titled "Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem

Most cell and tissue types can be made and matured from embryonic stem cells (ESC's) as long as they're in the proper setting with appropriate chemical signals that allow them to differentiate into certain cell types, eventually constructing 3-dimensional tissue structures. But other forms of synthetic tissue matrices are now required in order for this kind of technology to flourish. 

"Organ-specific extracellular matrices, properly prepared, are serving more and more as the appropriate structural scaffold for the recapitulation of a specific organ's tissues," said Peter C. Johnson, MD, Vice President of Research and Development for Avery Medical Products, and Co-Editor-in-Chief of Tissue Engineering. "This turns out to be especially true in an organ such as the lung, whose parenchyma must have a structure that accommodates atmospheric gas transmission as well as vascular, lymphatic and neural systems."

Cellular components were removed from natural lung tissue in order to make the natural growth matrix for ESC's. Making and using an acellular rat lung as a biological matrix "for differentiating ESC's into lung tissue" provided evidence of repopulation of the matrix, improved cell retention and differentiation into specific cell types within the lung. In addition, the development and maturation of of the cells into 3-dimensional complex tissues were reported, and according to researchers, lung tissue growth is progressing normally and is producing the correct chemical signals to continue development.

"We found that a combination of mechanical, enzymatic and physical processes provided the most efficient and gentle way to remove the cells from the underlying lung ECM without significant loss of collagen or elastin, the major components of the natural lung," the authors wrote. "The production and use of decellularized lung to support development of lung tissue may lead to design of better synthetic matrices for clinical use and to the eventual production of engineered lung tissues on matrices that are suitable for regenerative medicine purposes."

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RE: Woo Hoo!
By wvh on 8/20/2010 6:27:44 PM , Rating: 2
I'm going to regret ever opening my mouth in what will turn out to be yet another semi-political US-specific debate, but people rotting away inside of cancer and other fun diseases – for which cures might be developed – aren't exactly fitting the terms "common decency" either.

Things – oh the confusion – aren't that black-and-white in life, and different people might make different calls that need to be respected... out of "common decency".

Nobody likes using fetus stem cells, and nobody likes loved ones dying of treatable diseases. Where you take it from there, is nothing more but personal opinion masquerading as some sort of god-given morality.

RE: Woo Hoo!
By ppardee on 8/20/2010 11:37:21 PM , Rating: 1
Odd that you would use the phrase "[G]od-given morality" since that is the only morality that exists. Any other type of morality is completely cultural and subjective, and, therefore, utterly meaningless.

I don't think the debate is about abortion vs. cancer treatment, but if it were, the right thing to do would be let people die of cancer rather than deprive potentially healthy people of life to give someone the possible chance at living a longer life.

Why save a (usually) aging patient who's productivity and quality of life is only going to decline at the cost of the life of a child who's productivity and quality of life (usually and eventually) will only increase for many years?

But, again, thats not what the debate is about, so the point is moot.

RE: Woo Hoo!
By ddopson on 8/21/2010 1:10:20 AM , Rating: 2
Heh, because of course, God's morality is absolute ... within your worldview. Which must not be at all relative, compared to say, a Jewish person's slightly different version of God's morality, or even a person within your own religion whose explanation and interpretation of God's morality is slightly different than yours.

"A politician stumbles over himself... Then they pick it out. They edit it. He runs the clip, and then he makes a funny face, and the whole audience has a Pavlovian response." -- Joe Scarborough on John Stewart over Jim Cramer

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