Cell-depleted Lung Tissue a Matrix for New Rat Lung Using Stem Cells
August 20, 2010 2:41 PM
comment(s) - last by
(Source: Becoming Domestic)
Development and growth of new tissue proves to be successful
Researchers have released a new report showing the first successful
use of cell-depleted lung
in order to naturally create a new
from embryonic stem cells.
Joaquin Cortiella, MD, MPH, along with his research team members from Stanford University, University of Texas Medical Branch, Duke University and Brown Medical School, published their findings, a paper titled
"Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem
Cell Differentiation and Tissue Formation"
, Part A.
Most cell and tissue types can be made and matured from embryonic
(ESC's) as long as they're in the proper setting with appropriate chemical signals that allow them to differentiate into certain cell types, eventually constructing 3-dimensional tissue structures. But other forms of synthetic tissue matrices are now required in order for this kind of technology to flourish.
"Organ-specific extracellular matrices, properly prepared, are serving more and more as the appropriate structural scaffold for the recapitulation of a specific organ's tissues," said Peter C. Johnson, MD, Vice President of Research and Development for Avery Medical Products, and Co-Editor-in-Chief of
"This turns out to be especially true in an organ such as the lung, whose parenchyma must have a structure that accommodates atmospheric gas transmission as well as
, lymphatic and neural systems."
Cellular components were removed from natural lung tissue in order to make the natural growth matrix for ESC's. Making and
using an acellular rat lung
as a biological matrix "for differentiating ESC's into lung tissue" provided evidence of repopulation of the matrix, improved cell retention and differentiation into specific cell types within the lung. In addition, the development and maturation of of the cells into 3-dimensional complex tissues were reported, and according to researchers, lung tissue growth is progressing normally and is producing the correct chemical signals to continue development.
"We found that a combination of mechanical, enzymatic and physical processes provided the most efficient and gentle way to remove the cells from the underlying lung ECM without significant loss of collagen or elastin, the major components of the natural lung," the authors wrote. "The production and use of decellularized lung to support development of lung tissue may lead to design of better synthetic matrices for clinical use and to the eventual production of engineered lung tissues on matrices that are suitable for regenerative medicine purposes."
This article is over a month old, voting and posting comments is disabled
RE: Woo Hoo!
8/20/2010 6:27:44 PM
I'm going to regret ever opening my mouth in what will turn out to be yet another semi-political US-specific debate, but people rotting away inside of cancer and other fun diseases – for which cures might be developed – aren't exactly fitting the terms "common decency" either.
Things – oh the confusion – aren't that black-and-white in life, and different people might make different calls that need to be respected... out of "common decency".
Nobody likes using fetus stem cells, and nobody likes loved ones dying of treatable diseases. Where you take it from there, is nothing more but personal opinion masquerading as some sort of god-given morality.
RE: Woo Hoo!
8/20/2010 11:37:21 PM
Odd that you would use the phrase "[G]od-given morality" since that is the only morality that exists. Any other type of morality is completely cultural and subjective, and, therefore, utterly meaningless.
I don't think the debate is about abortion vs. cancer treatment, but if it were, the right thing to do would be let people die of cancer rather than deprive potentially healthy people of life to give someone the possible chance at living a longer life.
Why save a (usually) aging patient who's productivity and quality of life is only going to decline at the cost of the life of a child who's productivity and quality of life (usually and eventually) will only increase for many years?
But, again, thats not what the debate is about, so the point is moot.
RE: Woo Hoo!
8/21/2010 1:10:20 AM
Heh, because of course, God's morality is absolute ... within your worldview. Which must not be at all relative, compared to say, a Jewish person's slightly different version of God's morality, or even a person within your own religion whose explanation and interpretation of God's morality is slightly different than yours.
"Death Is Very Likely The Single Best Invention Of Life" -- Steve Jobs
Stem Cells Successfully Used to Treat Parkinson's in Rats
August 18, 2010, 7:38 AM
Mouse Fat Cells "Reprogrammed" for Clinical Use in Stem Cell Breakthrough
July 27, 2010, 10:26 AM
Scientists Grow Vascular Tissue Using Only Progenitor Cells
July 21, 2008, 7:57 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
NASA Opportunity Rover Breaks Record for Most Miles Traveled on Another Planet
July 29, 2014, 1:38 PM
Commercial Drones to Get Privacy Guidelines Via Executive Order
July 25, 2014, 5:34 PM
Pentagon's Priciest Project, F-35, Misses International Debut
July 25, 2014, 10:18 AM
Most Popular Articles
Lumia 830 Gets Major Upgrades Including New 20.1 Megapixel Toshiba Sensor
August 15, 2014, 6:00 PM
Windows Phone, BlackBerry Smartphone Market Share Falls to 2.5%, 0.5% Respectively
August 15, 2014, 9:44 AM
GM Concedes That the Cadillac ELR Doesn’t Really Compete with the Tesla Model S
August 15, 2014, 5:42 PM
Cell Phone Thief Calls 911 After Her Victim Chases Her and Her Male Cohort
August 14, 2014, 12:11 PM
Smarter Wired, Wireless Chargers Set to Shake Up Mobile Industry
August 14, 2014, 6:39 PM
Latest Blog Posts
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
Tesla vs. BMW: Who Has the Safer EV?
Feb 1, 2014, 2:56 PM
Justice Leaks Details of Next HTC One Two Flagship Phone
Dec 5, 2013, 4:04 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information