Cell-depleted Lung Tissue a Matrix for New Rat Lung Using Stem Cells
August 20, 2010 2:41 PM
comment(s) - last by
(Source: Becoming Domestic)
Development and growth of new tissue proves to be successful
Researchers have released a new report showing the first successful
use of cell-depleted lung
in order to naturally create a new
from embryonic stem cells.
Joaquin Cortiella, MD, MPH, along with his research team members from Stanford University, University of Texas Medical Branch, Duke University and Brown Medical School, published their findings, a paper titled
"Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem
Cell Differentiation and Tissue Formation"
, Part A.
Most cell and tissue types can be made and matured from embryonic
(ESC's) as long as they're in the proper setting with appropriate chemical signals that allow them to differentiate into certain cell types, eventually constructing 3-dimensional tissue structures. But other forms of synthetic tissue matrices are now required in order for this kind of technology to flourish.
"Organ-specific extracellular matrices, properly prepared, are serving more and more as the appropriate structural scaffold for the recapitulation of a specific organ's tissues," said Peter C. Johnson, MD, Vice President of Research and Development for Avery Medical Products, and Co-Editor-in-Chief of
"This turns out to be especially true in an organ such as the lung, whose parenchyma must have a structure that accommodates atmospheric gas transmission as well as
, lymphatic and neural systems."
Cellular components were removed from natural lung tissue in order to make the natural growth matrix for ESC's. Making and
using an acellular rat lung
as a biological matrix "for differentiating ESC's into lung tissue" provided evidence of repopulation of the matrix, improved cell retention and differentiation into specific cell types within the lung. In addition, the development and maturation of of the cells into 3-dimensional complex tissues were reported, and according to researchers, lung tissue growth is progressing normally and is producing the correct chemical signals to continue development.
"We found that a combination of mechanical, enzymatic and physical processes provided the most efficient and gentle way to remove the cells from the underlying lung ECM without significant loss of collagen or elastin, the major components of the natural lung," the authors wrote. "The production and use of decellularized lung to support development of lung tissue may lead to design of better synthetic matrices for clinical use and to the eventual production of engineered lung tissues on matrices that are suitable for regenerative medicine purposes."
This article is over a month old, voting and posting comments is disabled
8/20/2010 4:29:36 PM
I wonder how long I could hold my breath having replacement rat lungs. Seems like they would be too small.
RE: Rat lungs
8/20/2010 7:02:21 PM
I wonder why nobody has bred a fluffy-tailed rat,...and if they did,...would they call it a squirt, squrat, or just another damned squirrel. :P
“So far we have not seen a single Android device that does not infringe on our patents." -- Microsoft General Counsel Brad Smith
Stem Cells Successfully Used to Treat Parkinson's in Rats
August 18, 2010, 7:38 AM
Mouse Fat Cells "Reprogrammed" for Clinical Use in Stem Cell Breakthrough
July 27, 2010, 10:26 AM
Scientists Grow Vascular Tissue Using Only Progenitor Cells
July 21, 2008, 7:57 AM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information