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  (Source: Becoming Domestic)
Development and growth of new tissue proves to be successful

Researchers have released a new report showing the first successful use of cell-depleted lung in order to naturally create a new rat lung from embryonic stem cells.  

Joaquin Cortiella, MD, MPH, along with his research team members from Stanford University, University of Texas Medical Branch, Duke University and Brown Medical School, published their findings, a paper titled "Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem

Most cell and tissue types can be made and matured from embryonic stem cells (ESC's) as long as they're in the proper setting with appropriate chemical signals that allow them to differentiate into certain cell types, eventually constructing 3-dimensional tissue structures. But other forms of synthetic tissue matrices are now required in order for this kind of technology to flourish. 

"Organ-specific extracellular matrices, properly prepared, are serving more and more as the appropriate structural scaffold for the recapitulation of a specific organ's tissues," said Peter C. Johnson, MD, Vice President of Research and Development for Avery Medical Products, and Co-Editor-in-Chief of Tissue Engineering. "This turns out to be especially true in an organ such as the lung, whose parenchyma must have a structure that accommodates atmospheric gas transmission as well as vascular, lymphatic and neural systems."

Cellular components were removed from natural lung tissue in order to make the natural growth matrix for ESC's. Making and using an acellular rat lung as a biological matrix "for differentiating ESC's into lung tissue" provided evidence of repopulation of the matrix, improved cell retention and differentiation into specific cell types within the lung. In addition, the development and maturation of of the cells into 3-dimensional complex tissues were reported, and according to researchers, lung tissue growth is progressing normally and is producing the correct chemical signals to continue development.

"We found that a combination of mechanical, enzymatic and physical processes provided the most efficient and gentle way to remove the cells from the underlying lung ECM without significant loss of collagen or elastin, the major components of the natural lung," the authors wrote. "The production and use of decellularized lung to support development of lung tissue may lead to design of better synthetic matrices for clinical use and to the eventual production of engineered lung tissues on matrices that are suitable for regenerative medicine purposes."



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Woo Hoo!
By Ammohunt on 8/20/2010 3:38:27 PM , Rating: 2
Soon they will be able to grow people new lungs? I can't wait to start smoking again!




RE: Woo Hoo!
By FITCamaro on 8/20/10, Rating: -1
RE: Woo Hoo!
By rburnham on 8/20/2010 4:01:38 PM , Rating: 1
What?


RE: Woo Hoo!
By FITCamaro on 8/20/2010 4:15:08 PM , Rating: 1
What in my post is confusing?


RE: Woo Hoo!
By HeavyB on 8/20/2010 6:11:16 PM , Rating: 2
Human ES cells don't come from aborted fetuses. They come from fertilized embryos of only a few hundred cells that are fertilized in a petri dish (basically).


RE: Woo Hoo!
By Randomblame on 8/21/2010 8:34:02 PM , Rating: 2
Fixed it for you:

Human ES cells don't come from aborted fetuses. They come from fertilized embryos (human babies) of only a few hundred cells (that aren't allowed to grow larger) that are fertilized in a petri dish (basically).

So these "fertilized embryos" are grown in petri dishes, they are only allowed to grow to a few hundred cells, then they are "harvested" for stem cell use. Sounds like an abortion from the get go.
What part of that seems morally acceptable to you?

It's so ridiculous, save the whales - start a pirate fleet to go get them whalers, save the rats - harvest human baby meat to create new rat lungs, stop unemployment by taxing employers, fix the health care system by making people buy insurance they cannot afford...

Honestly - these people claim conservatives are uneducated...


RE: Woo Hoo!
By bigboxes on 8/22/2010 8:58:38 PM , Rating: 2
Every sperm is sacred.
Every sperm is great.
If a sperm is wasted,
God gets quite irate.


RE: Woo Hoo!
By YashBudini on 8/23/2010 2:32:16 AM , Rating: 1
quote:
If a sperm is wasted,

In a single sexual act how many sperm are released? Millions? How many successfully fertilize? One? A couple?

See any naturally occurring waste now? Planning on stoning to death the entire human race?

There's nothing in those big boxes, is there?


RE: Woo Hoo!
By clovell on 8/23/2010 10:29:13 AM , Rating: 2
Not sperm, embryos. There's a difference. I understand you're making a cultural reference in an effort to be funny, but this is a "tech" site - hard to do a non-sequitor joke in these parts.


RE: Woo Hoo!
By Ammohunt on 8/24/2010 3:45:15 PM , Rating: 2
Um you would have to had lived in a box for the last 30 years to not get the Monty Python reference.


RE: Woo Hoo!
By FITCamaro on 8/20/10, Rating: -1
RE: Woo Hoo!
By notquite1yet on 8/20/2010 4:40:34 PM , Rating: 3
I would think the issue is that your "aborted fetuses" remark is, at best, only tangentally related to the article content, and therefore reads as a troll. Especially since the tone of your follow up seems to assert that people are aborting fetuses *just* to get their stem cells, which is a ridiculous assertion to make and not something that anybody advocates.

Trolling is never fashionable.


RE: Woo Hoo!
By FITCamaro on 8/20/10, Rating: -1
RE: Woo Hoo!
By Paj on 8/21/2010 7:32:57 AM , Rating: 2
Keep the government out of it, let the market decide.


RE: Woo Hoo!
By FITCamaro on 8/22/2010 10:03:58 PM , Rating: 2
Let the market decide on murder? Sure...


RE: Woo Hoo!
By bigboxes on 8/21/2010 11:38:10 AM , Rating: 2
So, you're a social conservative on selective issues. LOL


RE: Woo Hoo!
By FITCamaro on 8/22/2010 10:04:53 PM , Rating: 2
Are you referring to me being ok with abortion in cases of rape, incest, or when the mothers life is in danger?


RE: Woo Hoo!
By YashBudini on 8/23/10, Rating: 0
RE: Woo Hoo!
By thestinkinggenius on 8/20/2010 4:34:39 PM , Rating: 2
Why not! I am for the most part anti-abortion but as long as abortions are legal why shouldn't they use them for something good.


RE: Woo Hoo!
By FITCamaro on 8/20/10, Rating: 0
RE: Woo Hoo!
By wvh on 8/20/2010 6:27:44 PM , Rating: 2
I'm going to regret ever opening my mouth in what will turn out to be yet another semi-political US-specific debate, but people rotting away inside of cancer and other fun diseases – for which cures might be developed – aren't exactly fitting the terms "common decency" either.

Things – oh the confusion – aren't that black-and-white in life, and different people might make different calls that need to be respected... out of "common decency".

Nobody likes using fetus stem cells, and nobody likes loved ones dying of treatable diseases. Where you take it from there, is nothing more but personal opinion masquerading as some sort of god-given morality.


RE: Woo Hoo!
By ppardee on 8/20/2010 11:37:21 PM , Rating: 1
Odd that you would use the phrase "[G]od-given morality" since that is the only morality that exists. Any other type of morality is completely cultural and subjective, and, therefore, utterly meaningless.

I don't think the debate is about abortion vs. cancer treatment, but if it were, the right thing to do would be let people die of cancer rather than deprive potentially healthy people of life to give someone the possible chance at living a longer life.

Why save a (usually) aging patient who's productivity and quality of life is only going to decline at the cost of the life of a child who's productivity and quality of life (usually and eventually) will only increase for many years?

But, again, thats not what the debate is about, so the point is moot.


RE: Woo Hoo!
By ddopson on 8/21/2010 1:10:20 AM , Rating: 2
Heh, because of course, God's morality is absolute ... within your worldview. Which must not be at all relative, compared to say, a Jewish person's slightly different version of God's morality, or even a person within your own religion whose explanation and interpretation of God's morality is slightly different than yours.


RE: Woo Hoo!
By thurston on 8/20/2010 11:17:22 PM , Rating: 1
Maybe if people like you would adopt unwanted children they wouldn't have to end up aborted fetuses.


RE: Woo Hoo!
By FITCamaro on 8/22/2010 10:06:46 PM , Rating: 2
Yes because all women looking to get an abortion try to get the baby adopted first.


RE: Woo Hoo!
By thurston on 8/22/2010 11:38:04 PM , Rating: 2
I bet more of them would if people such as yourself would step up to adopt them.


RE: Woo Hoo!
By YashBudini on 8/23/2010 2:26:52 AM , Rating: 2
Who would want his kind raising a kid?

And besides then he would lose his "double standard" status, so where would all the fun come from?


RE: Woo Hoo!
By clovell on 8/23/2010 10:31:46 AM , Rating: 2
Irrelevant & flame-baiting.


RE: Woo Hoo!
By thurston on 8/23/2010 5:30:35 PM , Rating: 2
How is my post irrelevant and flame-baiting? I don't see any other solution to the abortion issue other than adoption. You can't force someone to love an unwanted child and since FIT wants to outlaw abortion he should be part of the solution.


RE: Woo Hoo!
By amagriva on 8/22/10, Rating: 0
RE: Woo Hoo!
By FITCamaro on 8/22/2010 10:13:43 PM , Rating: 1
Great argument there. Even if I was a redneck, I'd keep being one just to piss you off.

I love it how idiots like yourself view anyone who's against your point of view as an uneducated redneck. But thats what happens when people watch Chris Matthews or Rachel Madcow or Keith Olbermann too much.

And I like polishing my muscle car. So fuck off. Nor do I listen to Rush Limbaugh.


RE: Woo Hoo!
By YashBudini on 8/23/2010 2:23:27 AM , Rating: 1
quote:
So fuck off

Great argument there.

And the lunatics you mentioned, did they exists before the likes of Murdoch and his multi-million dollar propaganda campaign, or after?

Oh, your status symbol/penis extrender is rusting, deal with it.


RE: Woo Hoo!
By clovell on 8/23/2010 10:33:30 AM , Rating: 2
You guys seem perfectly content to argue everything except the point.


RE: Woo Hoo!
By bh192012 on 8/23/2010 2:39:08 PM , Rating: 2
They should just wait and harvest fully developed lungs. Halting the growth process and then restarting it seems inefficient and perverse.


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