Print 95 comment(s) - last by PitViper007.. on Jun 30 at 12:36 PM

A new study shows that smoking tobacco cigarettes, like consuming alcohol, can lead to severe brain damage, though the mechanism is different. The study also suggests that second hand smoke exposure can also lead to brain damage.  (Source: The New York Times)

Perhaps that Guiness World Book Record for most cigarettes smoked wasn't such a good idea, now that the brain damage smoking tobacco causes is known...  (Source: Guiness World Book of Records)
Move over alcohol, brain damage has a new buddy

New research is set to be published in the July issue of the Journal of Neurochemistry that looks to offer yet another damning medical argument against smoking and allowing second hand smoke in public locations.  The new report finds that Tobacco smoke contains a compound which can cause brain damage.

The new study examined NNK, a procarinogen.  NNK is a toxic derivative of nicotine produced when the chemical is cured in preparation for use in cigarettes.  NNK is not found in other smoked drugs, such as cannabis.

Before the study it was thought that the compound could be damaging to the body, but it was unclear how damaging it was.  In the study, performed by Debapriya Ghosh and Dr Anirban Basu from the Indian National Brain Research Center (NBRC), it was found that the compound caused white blood cells in the central nervous system to attack healthy cells causing severe neurological damage.

Unlike alcohol or other forms of drug abuse, the drug does not impact brain tissue directly via oxidation or receptor damage.  Rather, it triggers an inflammatory immunological response that is believed to lead to Multiple Sclerosis and other brain diseases.

Both with in vivo, in mice, and in vitro tests, the researchers discovered that the compound elevated proinflammatory signaling proteins, proinflammatory effector proteins and other stress related proteins, and increased levels of proinflammatory cytokines, which act as molecular messengers between cells.  These factors led to increased activity by microglia, the brain's white blood cells responsible for attacking intruders.

The microglia turned on healthy cells, due to the increased level of these compounds.  States Professor Ghosh, "Considering the extreme economical and disease burden of neuroinflammation related disorders, it is extremely important from a medical, social and economic point of view to discover if NNK in tobacco causes neuroinflammation.  Our findings prove that tobacco compound NNK can activate microglia significantly which subsequently harms the nerve cells.

While most studies have focused on health threats from smoked tobacco, NNK is also present in chewing tobacco, helping make a stronger case against its use.  NNK is present in 20-310 nanograms in cigarettes, but is also can be present in concentrations as high as 26 nanograms in smoke filmed rooms.  This report adds more evidence that second hand smoke may damage non-smokers' health.

Concludes Professor Ghosh, "This research sheds light on the processes that lead to nerve cell damage in those who smoke cigarettes or consume tobacco products on regular basis."

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RE: Record Picture
By Chocobollz on 6/26/2009 5:13:41 PM , Rating: 1
I mean drinking -- while also extremely bad for you --- at least makes more sense to me why people start....because there are some tasty alcoholic drinks out there and well if you are thirsty it does help with that too.

Then you're different than me. I myself couldn't even smell the smell of alcohol. Don't know why but it makes me dizzy and having a bad headache so I've never get drunk in my entire life. I could only drink maybe a couple sips and after that I will feel very sick. And also, tobacco makes you feel sharper and awake while drinking makes you feel tired and uncomfortable, so I myself can't really understand why peoples likes to drink so much? Because drinking makes you lost your consciousness. I know it can help when you have problems (especially for alcoholics) but I would rather stay sharp and think about the problem, so I'm smoking.

I mean what's attractive about smoking?

I would asks the same question to you. What's attractive about drinking (and get drunk)? When you get drunk, you'll most of the time.. vomiting.... and embarassing yourself. I would say that's absolutely not an attractive things to see. And you'll get a little weird and makes some noise and even got a a fight on a bar because of it. Do you really consider those things as attractive??

I know both are bad for our health so we should avoid those. I myself are a smoker and already smoke for 8 years but of course I want to quit. Wish me luck ok? :-)

RE: Record Picture
By proneax on 6/27/2009 1:54:03 AM , Rating: 3
What is the appeal? Alcohol is a social lubricant, its cheap and temporary, easy to stop using, easy to use without endangering those around you.

The same is not true of cigarettes. They're expensive, both immediately and for long-term health. They're addictive and hard to quit, they're detrimental to the health of those near you, they're unattractive.

RE: Record Picture
By QueBert on 6/27/2009 3:48:38 AM , Rating: 2
they're unattractive to you. You still see models posing with cigarettes from time to time. And not too long ago (a few decades at most) you would see a lot of the Playboy playmates with them. There is definitely something sexy to many men about a female who smokes. If you don't believe me go on and look got smoking fetish videos, there are tens of thousands. It might be horrible for your health, but I an a lot of other men find females who puff to be totally hot.

RE: Record Picture
By PitViper007 on 6/30/2009 12:36:26 PM , Rating: 2
To each their own I guess. I can see a beautiful woman take a puff of a cigarette, and it just turns me right off. But like I said, to each their own.

RE: Record Picture
By tmouse on 6/29/2009 8:38:32 AM , Rating: 2
easy to stop using, easy to use without endangering those around you

In moderation absolutely should be added to this sentence. There are probably a lot more people who have been hurt or killed by people who do not know when to stop drinking than by second hand smoke. I am a cancer researcher and outside of some asthmatic reactions in young infants from families who are heavy smokers the second hand research is scientifically sketchy at best. I'm not defending smoking in any way but much of the 2nd hand data has been overblown by orders of magnitude, case in point this article, the research has no connection to second hand smoke, it is extremely unlikely the immunoeffects observed in the study could be observed in people exposed to second hand smoke.

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