Scientists Grow New Frog Eyes From Stem Cells
November 21, 2008 10:13 AM
comment(s) - last by
The frog tadpole on the left was implanted with stem cells to give it a new eye, seen on the right. The discovery could one day restore sight in humans.
(Source: Michael Zuber)
Scientist help disabled frogs live fuller lives -- and hopefully someday humans too
Technology promises to cure many ailments in the near future, from
to blindness. In the case of blindness, the only question is whether an
or an organic
stem-cell driven solution
will be the first to hit the market and gain mainstream acceptance.
Supporters of the stem cell approach got a big boost from new research at the SUNY Upstate Medical University, in Syracuse, NY. Researcher Michael Zuber and his colleagues report that by taking stem cells from frog eggs, they're able to prod the cells to grow into eyes when attached to tadpoles, baby frogs.
In order to get the
cells to become eyes
, the team genetically modified them, inserting transcription factors (proteins that trigger expression of other genes) which are known to regulate eye growth and development.
The scientists then implanted the cells into tadpoles missing an eye. The cells properly developed and differentiated into all seven types of retinal cells and appeared to have the proper structure. Additionally the new eye attached properly to the brain. In swimming tests the eye was shown to be working as implanted tadpoles only swam to the white side of the tank (normal behavior), while blind ones would also swim to the black side of the tank.
Would the technique work on mammals? The answer is maybe -- frogs naturally have a much easier type regrowing tissues than humans, in fact they can be triggered to regrow legs and many amphibians can regrow lost tails. Triggering proper differentiation in mammals is much more complex.
Nonetheless, Professor Zuber hopes that chemicals will be found from the research that can activate transcription factors in humans. Even if a full eye could not be grown, this could help people with retinal disorders regenerate ocular tissue.
In a separate, but perhaps equally intriguing study performed by Sujeong Jang of Chonnam National University, in South Korea, and his colleagues, the researchers were able to restore the hearing of deaf guinea pigs by implanting them with human neural stem cells obtained from human bone marrow.
This article is over a month old, voting and posting comments is disabled
11/21/2008 10:21:48 AM
But what have frog eyes ever done for me?
11/21/2008 10:25:46 AM
They put a roof over your head and food on your plate, now GO TO YOUR ROOM!
11/21/2008 11:10:28 AM
yum... good eats...
"People Don't Respect Confidentiality in This Industry" -- Sony Computer Entertainment of America President and CEO Jack Tretton
Single Neuron Un-Paralyzes Monkeys in Test
October 17, 2008, 11:14 AM
Stretchable Electronics Yield First Electronic Eyeball
August 7, 2008, 4:42 PM
Researchers Make Leap in Stem Cell Research; Cells Can Now be Produced From Any Tissue
July 2, 2008, 10:03 AM
Creationists are Mad About Google Doodle Depicting Evolution
November 24, 2015, 8:48 PM
DHS and TSA: Whoops, We Missed That 73 Airport Employees May be Terrorists
November 19, 2015, 2:16 PM
Star Wars Spinoff Film "Rogue One", Theme Park Attractions Announced
August 17, 2015, 12:20 PM
SpaceX Falcon 9's Seventh Supply Mission to ISS Ends w/ Fiery Stage 1 Explosion
June 28, 2015, 1:10 PM
Cool Science Video: Glowing Millipede Prowls the Nevada Desert
May 18, 2015, 12:00 PM
Newly Discovered Costa Rican Glass Frog is Kermit's Doppelgänger
April 22, 2015, 11:26 AM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information