New Nano-"Motherships" Help Further the Microscopic War on Cancer
September 16, 2008 10:15 AM
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A rendition of the special lipid nanoparticle, the inside is composed of a mixture of superparamagnetic iron particles, fluorescent quandum dots and anti-cancer drugs. The lipid structure is coated with F3, a special cancer-seeking protein, to help it home in on cancer cells and deliver its payload.
(Source: Ji-Ho Park, UCSD)
Like a stealth jet, new nanoparticles evade the body's defenses while delivering chemical markers and lethal toxins to cancer tumors
Studying and developing treatments for cancer is possibly one of the most publicized fields in medical science in current times. There has been a deluge of new and promising treatments recently using
nano- and macro-scale particles
to, via the bloodstream,
deliver anti-tumor drugs
or anti-tumor weapons directly to the site of cancerous growths.
Building on past breakthroughs with these microscopic particles as drug ferries, a group of researchers from UC San Diego, UC Santa Barbara and MIT will shortly
publish new work
with a refined lipid-based transport system. While it is not the first lipid-based particle, it may be the first to be as robust as the researchers claim.
The specially engineered lipid structure, instead of simply carrying a toxin or heat bomb to cancer cells, is actually a multi-purpose unit. Coated with F3, a special cancer bloodhound protein, and filled with various imaging components (superparamagnetic iron nanoparticles for NMRIs and fluorescent “quantum dots” for fluorescence imaging) and anti-cancer drugs (doxorubicin), the tiny “motherships” were shown to evade the body's aggressive immune system for several hours while ferreting out cancer cells and delivering their payloads.
The structure is among the first to pack imaging and cancer killers in the same package. The success surprised even the researchers. Michael Sailor, a professor of chemistry and biochemistry at UCSD who headed the team of chemists, biologists and engineers, states, "The fact that the ships can carry very dissimilar payloads—a magnetic nanoparticle, a fluorescent quantum dot, and a small molecule drug—was a real surprise."
the Germany-based chemistry journal
The team is continuing to explore the possibilities of specialized coatings for the lipid transports. They are looking to develop more proteins that will seek out certain types of tumors or organs in the body and deliver their tailored cargo to those sites.
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RE: something scares me
9/16/2008 7:18:23 PM
Once you really think about it, there really isn't very much potential to use this as a weapon. Doing so would be ridiculously impractical. Consider poisons such as ricin, which is cheap, easy to make (you could probably figure out how to make it online easily enough), is unaffected by the immune system, kills very swiftly in small doses, and is much easier to deliver to victims.
The only potential 'evil' use of this is to sectretly assassinate people, but even then there are plenty of cheaper, more common, easier to make, and more untraceable, poisons that can be used.
I suppose I suppose this
be used by a serial killer who, for some unknown reason, might want to deliver specific poisons to a specific part of victims' bodies. But then, how would that be any really worse than a psycho with a knife?
“Then they pop up and say ‘Hello, surprise! Give us your money or we will shut you down!' Screw them. Seriously, screw them. You can quote me on that.” -- Newegg Chief Legal Officer Lee Cheng referencing patent trolls
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