Print 7 comment(s) - last by myhipsi.. on Jul 17 at 9:17 AM

It's looking pretty bad for cancer these days thanks to our friend nanotechnology.

Last week, DailyTech covered a new type of nanoparticle intended for use as a cancer therapy. The polymeric particle would carry the common chemotherapy drug doxorubicin to the site of metastasizing tumors, where it would release the chemical, destroying the tumor's cells while leaving healthy cells largely unaffected. The treatment, designed by UCSD medical scientists, works very well on the intended target, but saw little to no results in affecting primary tumors.

Researchers at Washington University, led by Karen Wooley, Ph. D., are developing a similar delivery vehicle to ferry doxorubicin to tumors in the brains of children, where heavy chemotherapy can irreparably damage the developing bio-computer. Though her group uses the same family of polymeric nanoparticles, the delivery and effectiveness differs from UCSD's treatment.

Some of the properties of the nanoparticle important to Wooley's group are its carrying capacity and the way it releases the cancer toxin into the body. Most polymeric based nanoparticles have at best a three to four percent drug capacity. Wooley's group's particles boast an up to 19 percent loading, five times the typical delivery vehicle's capacity. While the large increase in toxin is beneficial, not all of the toxin in these particles will be released.

Another difference is the rate at which the drug is released into the patient. Most cancer-targeting nano and macroparticles verily explode a cancer cell in one way or another. The WU group's particles are designed to release the toxin more slowly over time. The group is working to tune these properties further, allowing a tailored particle delivery vehicle.

One area yet to be refined by Wooley's team is the actual targeting method for binding the particles to cancer cells. The typical approach has been to use a ligand structure targeting protein expressions unique to cancerous cells. While this is under development, another method, exploiting the “enhanced permeability and retention effect” of tumors would rely on passive diffusion to absorb the particles into a tumor where the doxorubicin could be released directly into the mass.

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Very glad to hear this field is progressing
By devolutionist on 7/16/2008 8:59:03 AM , Rating: 5
I had a child of mine die back in 2001 from a pineoblastoma (brain tumor right in the middle of his brain), and the treatment options that were available back then were just horrible.

The problem with pediatric cancer therapies is that because their bodies are growing so fast, there are lots of treatment options that adults can survive that infants simply cannot - like radiation therapy and most chemo.

Hopefully this and virus-based cancer "immunization" research will put an end to the suffering of pediatric cancer patients.

There should also be research focused on the supporting drugs that are part of the cancer therapy regimen - specifically ways to lower the cost of GCSF (granulocyte colony-stimulating factor), commonly sold under the brand name "Neupogen". This drug is a critical part of the regimen that stimulates white blood cell development. This is important because the immune system of cancer patients (both adult and pediatric) are simply decimated by chemo. The problem with it is that it costs $2000 PER VIAL, and each vial is single use. When you go through a couple of those a month, it adds up very quickly. Luckily our insurance covered it (trust me though, they did not go quietly) but I'm sure many that were in our situation simply could not afford that treatment option - which is a horrible choice for any parent in that situation to have to make.

RE: Very glad to hear this field is progressing
By Chadder007 on 7/16/2008 9:43:09 AM , Rating: 1
I have an aunt that is dying of brain cancer too, it won't be but probably a few more weeks for her.

By Orbs on 7/16/2008 2:54:01 PM , Rating: 2
My heart goes out to both of you and my thoughts and prayers continue to focus on finding treatments like this (and getting them out to the public).

It's great that so many smart people in many different labs/universities are working on this.

"Nowadays you can buy a CPU cheaper than the CPU fan." -- Unnamed AMD executive
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