New Nanoscale Cancer Buster Wiggles Its Way to Tumors
May 7, 2008 9:10 AM
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Scientists fish for tumors with nanoworms.
Another nanoscale anti-cancer device has arrived on the growing scene. Similar to MIT's
, the new treatment would involve a sticky "nanoworm." The particles, developed jointly by scientists at the Universities of California at San Diego and Santa Barbara along with MIT, resembles a gummi worm made of small spheres.
The worms are made from spherical nanoparticles of iron oxide, joined together and coated with a polymer derived from dextran. Each worm consists of eight nanoparticles and measures approximately 30 nanometers in length. That makes them about three million times smaller than their earthworm brethren.
There are multiple advantages in using the new nanoworms over single particle approaches for locating and delivering cancer destroying drugs directly to tumors. The structure allows the worms to slip through the bloodstream with less opposition than single particles, which are more easily detected and driven out by the body's immune system functions. This keeps them in the body longer, giving them more time to find targets.
Another advantage is the amount of anti-cancer toxins a single worm can carry versus a single particle. Obviously by having more surface area, more toxins could be attached, thus serving target tumors a more lethal dose. Not only could more drug be attached, but more of the peptide which causes the particles to stick to the tumors, called F3, can share the surface, making them more likely to lock on when a tumor is located.
Yet another is that the worms' construction material, iron oxide, has the quality of being superparamagnetic, which causes them to light up an MRI scan in areas of suspicion. Even if only one of the worms finds a certain target, it is more easily detected than single superparamagnetic particles, like MIT's, because of its size.
While the results of the group's work are impressive, they are still researching different ways to attach anti-cancer drugs to the nanoworms, as well creating special chemicals that will allow administers to target specific types of tumors. Once a tethering method is found, it could allow the worms to be even more lethal to cancer cells than MIT's nanoparticle or
Rensselaer Polytechnic's nanotube
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5/8/2008 10:52:58 AM
Is referencing a patent for method is abbreviating to obfuscate? You can't fit a thesis into 2500words. Half a paper is taken up trying to explain the ever increasingly complex methods and referencing the ever increasing prior work. With more people more scientist/doctors/ and more R&D money .. the journal need to allow more papers and increase the length. By the time you fit confidence intervals, provide multiple graphs there is very little space for the rest of the text.
5/8/2008 12:17:33 PM
The patent reference is really only a small problem. I have read papers that reference methods in other papers that are also only references to another paper and so on. Not specifically stating the example they used (there are 3 in the patent) and giving specific details on their changes are absolutely critical to reproducing their work and using it to build upon. I can probably figure out which general formula they used but I can never figure out the concentrations of the solutions without specifically asking. This should not be necessary, I am not in their field I just feel “nanoworms” may be useful in another application. Ultimately I will contact them but I am left with the feeling that if they do not want to openly share with the scientific community can one really trust them not to take an idea and use their head start to their own advantage. This is not a feeling scientists should have; it benefits no one. Leaving this out effectively negates any value the paper has. It just becomes an Unconfirmable narrative.
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