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Louis Picker, M.D.  (Source: OHSU)
The team is now trying to figure out why only half of the monkeys were successful in being treated while the other half were not

A new vaccine candidate has shown promise for HIV/AIDS patients by clearing a very aggressive form of the virus. 

Researchers from Oregon Health and Science University (OHSU) -- led by Dr. Louis Picker -- have developed a vaccine that specifically targeted the simian immunodeficiency virus (SIV), which is an aggressive form of HIV that turns into AIDS. 

HIV is tricky because it's difficult to clear completely from the body. While it can be undetectable in blood or tissue, it could hide in other places like organs and reappear later. SIV is even worse, replicating up to 100 times faster than HIV and can cause AIDS in only two years if it goes unnoticed. 

The team created the vaccine by using a cytomegalovirus (CMV), which is another virus just as persistent as SIV, but doesn't cause disease. The vaccine generated an immunoresponse that nearly mimicked the normal immunoresponse generated by CMV, creating effector memory T-cells that can search and destroy target cells. These cells remained in the system and were persistent, since the immunoresponse was similar to that of a normal CMV, and successfully targeted SIV-infected cells until the virus disappeared from the body.

This is important, because while other vaccines produce an immunoresponse too, the response diminishes over time.

The team tested the vaccine on monkeys with initial signs of infection, and found that about fifty percent of the monkeys tested showed signs of the infection fading before disappearing completely. 

"The virus got in, it infected some cells, moved about in various parts of the body, but it was subsequently cleared, so that by two or three years later the monkeys looked like normal monkeys," said Dr. Picker. "There's no evidence, even with the most sensitive tests, of the SIV virus still being there."

The team is now trying to figure out why only half of the monkeys were successful in being treated while the other half were not. But the OHSU researchers hope this vaccine candidate one day translates into a human form of the vaccine. 

Source: Gizmag

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The other half...
By Motoman on 9/13/2013 1:22:22 PM , Rating: 3
...unfortunately, the other half of the monkeys that aren't cured start dancing and singing One Direction songs non-stop.

Scientists fear that the rate of killing such OD-infected critters would instantly surpass the death rate of HIV/AIDS as even they themselves could only witness such a display for a couple minutes before beating the monkeys to death with office chairs and keyboards.

RE: The other half...
By Flunk on 9/13/2013 2:45:51 PM , Rating: 2
I don't know about that, if the right environment I bet you could make a lot of money with monkeys that sing One Direction songs. You just need the right marketing.

RE: The other half...
By Alexvrb on 9/13/2013 11:28:45 PM , Rating: 2
I think that would still be an improvement over One Direction singing their own songs.

RE: The other half...
By Piiman on 9/14/2013 10:22:28 AM , Rating: 4
They could call themselves "The Monkey's" ...oh wait

Yea But...
By Acupuncture on 9/13/2013 7:40:22 PM , Rating: 2
How many became autistic? That's the REAL question....

RE: Yea But...
By Alexvrb on 9/13/2013 11:33:42 PM , Rating: 2
They're monkeys. How bad could it be? You might not even notice. :P

On a serious note, if you've already got HIV you might want to take the risk. It's not as cringe-worthy as something going terribly wrong from a strictly preventative vaccine for a flu or something.

Also, you can develop all sorts of horrible complications from being bitten by a tick or other parasite. I know of a couple of people that developed allergies to red meat as a result of deer ticks. Life is a real ... sometimes.

RE: Yea But...
By CowKing on 9/14/2013 12:53:03 PM , Rating: 3
Vaccines don't cause autism.

RE: Yea But...
By Lord 666 on 9/14/2013 10:33:22 PM , Rating: 2
You can get syphilis by banging sheep.

RE: Yea But...
By althaz on 9/15/2013 10:59:06 PM , Rating: 2
I'm not going to ask how you know that...

porn industry
By Jeffk464 on 9/13/2013 1:45:32 PM , Rating: 1
Thank god, now we can do away with the condom law for the porn industry. :)

RE: porn industry
By Monkey's Uncle on 9/13/2013 3:18:50 PM , Rating: 5
Only for monkey porn.

RE: porn industry
By troysavary on 9/13/2013 7:43:53 PM , Rating: 2
Your nephew does porn?

By ipay on 9/13/2013 1:04:02 PM , Rating: 5
So I guess this really is some serious monkey business.

By genedude on 9/15/2013 2:24:06 PM , Rating: 2
cytomegalovirus (CMV), which is another virus just as persistent as SIV, but doesn't cause disease
Although CMV is often asymptomatic, it can cause serious disease in HIV patients and to a developing fetus. The researchers use a CMV virus vector, which is presumably modified so it does not cause disease itself but still has enough immunogenic properties that the body’s immune system will still react to it.

This vaccine is very promising, but it remains to be seen whether it will translate to humans and HIV without significant side effects.

That's an impressive vaccine indeed...
By Boze on 9/17/2013 2:34:55 PM , Rating: 2
...considering its so potent that it cured an infection the monkeys didn't even have...

What did they put into it, such that it cures HIV in monkeys not even infected with HIV?

By dsosce on 9/16/13, Rating: 0
By DianeGAlexander on 9/13/13, Rating: -1
RE: DianeGAlexander
By ClownPuncher on 9/13/2013 5:39:33 PM , Rating: 5
I want to fart in your mouth and sew it shut.

RE: DianeGAlexander
By strapmonkey on 9/13/2013 9:51:21 PM , Rating: 2
Why stop with flatus? You've given that much effort, might as well go all the way (POOP!). And I, for one, wholeheartedly support your effort, to the point of sitting on Diane's chest, thus to restrain her, whilst you do your thing (with my back to you, of course, I'm no sicko).

By rya14 on 9/13/13, Rating: -1
By amaryllis on 9/15/13, Rating: -1
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