Print 12 comment(s) - last by Silver2k7.. on Dec 14 at 2:43 AM

Using insulin-producing spermatogonial stem cells makes the therapy look promising

Georgetown University Medical Center (GUMC) researchers have discovered that testicular tissue may be used to grow insulin-producing cells for men with type 1 diabetes. 

G. Ian Gallicano, Ph.D., study leader and associate professor in the Department of Cell Biology at GUMC, and his team of researchers at GUMC, have found that men with type 1 diabetes could potentially grow insulin-producing cells with their own testicular tissue. 

Up until now, other similar forms of therapy for type 1 diabetes patients have failed. For instance, researchers tried transplanting insulin-secreting islet cells from deceased patients into those with diabetes, but the body has the capability of rejecting them. In addition, researchers have used induced pluripotent stem (IPS) cells, which are adult stem cells that act like embryonic stem cells by being programmed with other types of genes, in the past to cure mice of diabetes. The problem with this therapy was that it caused teratomas, or tumors, in transfected tissue.

But now, Gallicano and his team have found a new stem cell therapy. They extracted human spermatogonial stem cells (SSCs) from the testicular tissue of a deceased patient, and found that these stem cells could transform into beta islet cells that secrete insulin, which are usually found within the pancreas. Just 1 gram of testicular tissue produced 1 million stem cells. 

What makes this new process unique is that the stem cells are capable of morphing into the insulin-producing beta islet cells without the use of any extra genes, which are used in most labs to help transform stem cells into various kinds of tissue. They have the ability to transform without additional genes because SSCs already have the required genes needed to become embryonic stem cells.

"No stem cells, adult or embryonic, have been induced to secrete enough insulin yet to cure diabetes in humans, but we know SSCs have the potential to do what we want them to do, and we know how to improve their yield," said Gallicano. 

Gallicano and his team have already tested this therapy on diabetic mice. They transplanted the SSCs into the backs of diabetic mice, and found that the cells produced enough insulin to decrease glucose levels for a week. The GUMC team plan to improve the therapy so that it can last longer. 

This study was presented at the 50th annual meeting of the American Society for Cell Biology in Philadelphia. 

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All I am going to say is
By Orchunter on 12/13/2010 10:17:04 AM , Rating: 2
OUCH !!!

RE: All I am going to say is
By corduroygt on 12/13/2010 10:24:02 AM , Rating: 3
Trust me, I have friend with Type 1 diabetes, and he'd easily trade giving up a gram of his balls for not having to get insulin shots every day.

RE: All I am going to say is
By kattanna on 12/13/2010 10:42:08 AM , Rating: 2
so now those poor guys who wake up in a bathtub of ice missing a kidney will also be missing some other things


RE: All I am going to say is
By acer905 on 12/13/2010 10:49:33 AM , Rating: 2
Especially true when you consider that:

A) Kidneys are a bit difficult to get to.

B) While you have two kidneys, you need one to live. Thus they can only take one if they want to avoid murder charges.

C) Neither A nor B are true for this "procedure"

RE: All I am going to say is
By Souka on 12/13/2010 1:51:39 PM , Rating: 2
I"m Type I.... 30+ yrs of being so... I'd give up a ball, maybe both, for a perm. fix.

Very cool... but even if it's a magical fix, it'll be 10+ years before available. :(

Does this only work for the host?
By MrTeal on 12/13/2010 10:43:36 AM , Rating: 3
Because if God forbid my wife even got diabetes, I would gladly set aside a section of my balls to produce insulin for her. I even have the perfect delivery mechanism for the shots she's going to need several times a day...

RE: Does this only work for the host?
By Souka on 12/13/10, Rating: 0
By Silver2k7 on 12/14/2010 2:43:11 AM , Rating: 2
Growing up with someone who has diabetes, you see all the close calls.. even if most of the time a glass of coca-cola, milk or juice will do the trick.

Some people go blind from it and others loose their feet to the dissease.....

So I don't know if id go so far as to say that it isnt that bad. If there was an easy cure im guessing you would be in line really fast.

By dondino on 12/13/2010 9:25:08 PM , Rating: 2
Good man. I'd give my left nut for my wife too. :)

By Scrith on 12/13/2010 5:35:24 PM , Rating: 3
Anyone who tries this has really got balls.

By dayanth on 12/13/2010 11:12:44 AM , Rating: 2
"What are you working on?"
"I'm seeing what beneficial properties we can milk from sperm. I think we can cure Type-1 diabetes, make the blind see, and increase the protein intake for people with deficiencies."

heh. But really "probably" "may be" "potentially" are some key words in the article I'm not too fond of seeing. I just really hope that they make some solid proof that they can help people with Type-1 and finally have for them something other than an insulin injection and testing blood sugar regularly.

By radium69 on 12/13/2010 11:48:23 AM , Rating: 2
I hope that they can find a solution for the type 1 diabetes.
I have type 1 aswell. And although I can live like a normal person. The annoying thing is that I can't work properly because of bloodsugar shifting up and down.

I would seriously give up my balls for that. I'm a diabetic for over 10 years, and it really is starting to nag me.
I have to think about everything I do or eat. My freedom is basically gone.

I hope they keep up the good work ;)

I have been reading a lot of articles about the Isle's transplantation and all that. But this really looks promising.

Diabetes is a nasty thing I can tell. It's not pleasant at all when you can't eat what you normally can. And you can't do something, someone else can.

Atleast I have a bit of hope again.
Diabetes has been on the scene for a long time. It's time to get rid of it and help a lot of people.

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