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Human induced pluripotent stem cells "hot" topic among researchers focused on regenerative medicine.

Neurons from human induced pluripotent stem cells (iPSCs) used to treat rats with Parkinson's Disease (PD) provided promising results for scientists at the Buck Institute for Age Research.
Researchers used human iPSCs derived from skin and blood cells and manipulated them to become dopamine-producing neurons.  Dopamine, a neurotransmitter produced in the mid-brain, aids critical functions, including motor skills.

Those suffering from PD are unable to produce enough dopamine in their bodies.  PD affects 1.5 million Americans and results in tremors, rigidity and slowness of movement.

The findings at the Buck Institute can be used to manufacture the type of neurons needed to treat the disease and makes way for the use of iPSC's in various biomedical applications, that's according to a release issued by the Institute and a paper authored by the team in the August edition of Stem Cells journal.

"These cells are reprogrammed from existing cells and represent a promising unlimited source for generating patient-specific cells for biomedical research and personalized medicine," said the lead author of the study, Xianmin Zeng, Ph.D. "Human iPSCs may provide an end-run around immuno-rejection issues surrounding the use of human embryonic stem cells (hESCs) to treat disease. They may also solve bioethical issues surrounding hESCs."

The team of scientists transplanted iPSC-derived neurons into rats that had mid-brain injury similar to that found in human PD. The cells became functional and the rats showed improvement in their motor skills.

"The studies are very encouraging for potential cell therapies for Parkinson's disease," said  President of the California Institute for Regenerative Medicine, Alan Trounson, Ph.D. "The researchers showed they could produce quantities of dopaminergic neurons necessary to improve the behavior of a rodent model of PD. We look forward to further work that could bring closer a new treatment for such a debilitating disease." 

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By TheDoc9 on 8/18/2010 10:42:18 AM , Rating: 5
This is one of the few stories on dailytech that's truly meaningful and likely to have real world application.

RE: Excellent
By TheShniz on 8/18/10, Rating: 0
RE: Excellent
By SSDMaster on 8/18/10, Rating: 0
RE: Excellent
By chenjf on 8/18/2010 3:03:15 PM , Rating: 3
Anand used to be the #1 place to go for all things tech, and now all the blatant political and ecological bias makes me want to puke.

This website is and not

RE: Excellent
By Murloc on 8/19/2010 5:16:57 AM , Rating: 2
the dailytech news are just a square of the anandtech site, but the site is completely separate.

This is not anandtech.
Anandtech is a website about computers and IT.
Dailytech is about science discoveries, tech gossip, and biased mick stories. There is the article with computer reviews, but not more.

RE: Excellent
By Ammohunt on 8/18/2010 1:57:11 PM , Rating: 2
lets hope and pray this works in humans we are long overdue for Back to the Future 4!

RE: Excellent
By The Raven on 8/18/2010 3:36:18 PM , Rating: 2
Does it take 1.21 'jigga'watts to power this miraculous technology?

RE: Excellent
By kaborka on 8/18/2010 3:58:13 PM , Rating: 2
This is great news for me. I've got early PD. With luck this will be developed for human "standard of care" before I get crippled by it. Already I can't play FPS any more :(

RE: Excellent
By Paj on 8/20/2010 3:22:32 AM , Rating: 2
Sorry to hear... I hope that this is ready in time for you

RE: Excellent
By enatai on 8/19/2010 5:53:27 PM , Rating: 2
This is great news and very encouraging. I am a stem cell scientist working on stem cell-based regenerative medicine therapies. This is one of the first studies to use iPS cell technology in a transplant type of context and to me one of the most important aspects of it was that there were no tumors as a side effect. I wish the study had gone on longer because tumors can form later, but it is very encouraging. My lab discusses these issues on our blog at

Paul Knoepfler, PhD

"What would I do? I'd shut it down and give the money back to the shareholders." -- Michael Dell, after being asked what to do with Apple Computer in 1997

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