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AFIRM's new spray-on-skin could be used to treat burns and greivous wounds. Immature skin cells harvested from the patient promote healthy regrowth of the damaged skin.  (Source: McGowan Institute for Regenerative Medicine)
Advances in regenerative medicine and stem cell research will help wounded soldiers and civilians alike.

AFIRM, the Armed Forces Institute of Regenerative Medicine, has some lofty, but important goals. As covered by DailyTech previously, the goal of the Army-led organization is to help and heal our wounded fighting men and women, allowing them to return to the productive lives they gave to their country. Some of the current goals, limb regeneration especially, may seem lofty, but such things rarely stand in the way of human determination for long.

Some of the stem cell research done by AFIRM members is already showing promising results. Stephen Badylak, a pathologist at the McGowan Institute for Regenerative Medicine at the University of Pittsburgh's announcement last year that a magical “pixie dust,” created from pig bladders, regrew the severed fingertips of two patients left a mark in the medical community. The dust contains molecules that signal growth factors, overriding the typical scar tissue response when a limb is severed. In just six weeks, the fingertips grew back completely, fingernails included. Badylak is presently doing further research into regrowing more complicated extremities such as arms and legs.

Anthony Atala, a Wake Forest University tissue engineer, has developed an ink jet printer capable of printing entire organs, one layer of cells at a time. The special printer uses cartridges filled with a mix of tissue types, growth factors and nutrients. He has already successfully printed a rat heart, and plans to have a portable model developed in the next five years that can print skin tissue directly onto flesh wounds in battlefield hospitals.

The newest development in progress by AFIRM is nothing less than spray-on skin. The process involves harvesting cells known as keratinocytes from a patient's own skin. Keratinocytes are immature skin cells, which the body constantly produces to create new skin tissue as surface tissue dies. The cells are put into a solution which is then sprayed over a wound.

Clinical trials with the process involved 16 burn patients and showed extremely promising results. Not only did the cells promote growth in the wounds, the recovery time was similar to skin grafting, the standard approach to burn repairs, but without the complications or aesthetic scarring involved.

While the $250 million project is aimed at helping our military men and women, the results of the hard work by AFIRM members will no doubt spill over into civilian medicine, much the way most military technology eventually does. If doctors can print new organs and skin in the battlefield, they can do it at accident scenes on domestic soil. AFIRM may enable one of the most significant leaps in regenerative medicine in history, all thanks to stem cells of various construction and the human desire to help those who have helped and protected us.



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I. Robot.
By jadeskye on 6/26/2008 9:14:47 PM , Rating: 4
Reminds me of that scene from I. Robot where will smith repairs his arm.

Crazy how quickly science fiction becomes science fact these days.




RE: I. Robot.
By Brandon Hill (blog) on 6/26/2008 9:19:53 PM , Rating: 2
Yup, that's the first thing I thought of as well.


RE: I. Robot.
By jadeskye on 6/26/2008 9:22:11 PM , Rating: 2
Great minds ^_^

Technology never stops amazing me.


RE: I. Robot.
By FaceMaster on 6/27/2008 7:55:18 AM , Rating: 2
WARNING: If contact with eyes, go for cataract operation


RE: I. Robot.
By tastyratz on 6/27/2008 8:47:53 AM , Rating: 2
only if you don't want fingertips growing on your eyes


RE: I. Robot.
By jbartabas on 6/26/2008 9:37:49 PM , Rating: 2
Remind me of a scene in Starship Troopers.

I'd like to see the real thing.


RE: I. Robot.
By Adonlude on 6/27/2008 1:48:46 PM , Rating: 4
quote:
Badylak is presently doing further research into regrowing more complicated extremities such as arms and legs.
Soon to come from the makers of spray on skin, Spray On Arms (tm) and Spray On Leggs (tm).


RE: I. Robot.
By JediJeb on 6/28/2008 2:48:12 PM , Rating: 4
Oh I can hear the annoying commercials now " Arm on! Apply directly to the stump! Arm on! Apply directly to the stump! Arm on! Apply directly to the stump!" over and over and over .....


RE: I. Robot.
By InternetGeek on 6/26/2008 10:33:02 PM , Rating: 2
So the guy can print organs... I wonder how long until famous people start to sale blue prints of themselves...

"Here, this is a promotional copy of me to take home"


RE: I. Robot.
By nstott on 6/26/2008 10:59:26 PM , Rating: 2
That's not I.Robot. That's The Island (or at least similar).


RE: I. Robot.
By Jedi2155 on 6/26/2008 11:27:09 PM , Rating: 5
I wouldn't mind being able to a get a promotional copy of Jessica Alba ;).


RE: I. Robot.
By Samus on 6/27/2008 5:20:40 AM , Rating: 2
/claps his hands


RE: I. Robot.
By PAPutzback on 6/27/2008 9:40:31 AM , Rating: 2
Somebody beat me to the five. Congrats. I'd have to print off about ten of them. A few for work around the house, a few for the bedroom, a few to just walk around.


RE: I. Robot.
By HrilL on 6/27/2008 11:10:18 AM , Rating: 2
I'd like her 18 year old model. ;)


RE: I. Robot.
By lazylazyjoe on 6/27/2008 6:43:04 AM , Rating: 2
I'll take a lucy lui-bot from KidNapster... or a marilyn monroe-bot. Just watch out for Electro-gonorrhea. The noisy killer.


RE: I. Robot.
By Chudilo on 6/27/2008 11:27:08 AM , Rating: 2
Well we don't want to clone the whole person.
Think about the potential for plastic surgery.
Instead of using a silicone implant, grow some extra breast tissue of your own. Or Angelina Jolie's lips, JLo's butt and so on and so forth.


RE: I. Robot.
By Jedi2155 on 6/28/2008 4:10:39 AM , Rating: 3
Somehow reading your comment gave me the mental picture of growing Jolie's lips onto JLo's butt....somehow that just didn't seem right!


RE: I. Robot.
By encryptkeeper on 6/27/2008 8:39:44 AM , Rating: 2
Dr McCoy did this in the original Star Trek series as well. But then, they hypospray is a reality now as well. Now we just need transporters, replicators and holodecks.


So, any bets?
By phisrow on 6/26/2008 9:25:22 PM , Rating: 2
So, how do you think this will go down among those who hold both "support the troops" and "no embryo research" as articles of faith?




RE: So, any bets?
By Vim on 6/26/08, Rating: 0
RE: So, any bets?
By ADDAvenger on 6/26/2008 9:42:06 PM , Rating: 5
Stem cell research doesn't necessarily involve embryos, do us all a favor and google adult stem cells


RE: So, any bets?
By DanoruX on 6/26/2008 10:47:40 PM , Rating: 1
50% will grow a brain and realize it's a great thing, the rest will blow up in confusion. :D


RE: So, any bets?
By Visual on 6/27/2008 4:48:42 AM , Rating: 2
Nah, those that grow a brain may then regret it, once they realize the truth in "ignorance is bliss" ;)


RE: So, any bets?
By nstott on 6/26/2008 10:57:49 PM , Rating: 2
Most of the major advances in medicine have been made with adult stem cells. Although, embryonic stem cells do a great job of making Parkinson's patients worse.

In 2003, I tried to set up donating my daughter's umbilical cord and placenta (both rich in highly pliant, undeveloped stem cells) to medical research before she was born, but that particular hospital didn't have any program for doing such in the Boston area. Keep in mind that the Boston area, with Harvard Medical and Children's Hospital Boston, has some of the most advanced medicine and research in the world. I'm guessing they had multiple programs to collect aborted fetuses for stem cell research.

While I'm opposed to abortion (except in the case of rape or the life of the mother being in danger), I'm not necessarily against embryonic stem cell research. Ironically, I think cloning an individual to use genetically identical stem cells is a good idea.


RE: So, any bets?
By RabidDog on 6/27/2008 9:16:00 AM , Rating: 2
My wife gave birth to our daughter last November. We actually discussed donating 'birth stuff' to a research program.
On doing research, I found out a couple of things.
1) There is already more 'birth stuff' availible for research then will be used for something like 50 years.
2) You had to pay some cost in the processing of this material.
3) You loose your rights to it. If your child has the 'special gene' that cures everything, the Pharma's make all the money, and you get nothing.
4) The research is at a VERY primitive stage, and it's a real crap shoot if anything will come out of it.

In the end, we let it go. The hospital has their own process.


RE: So, any bets?
By InsaneGain on 6/27/2008 1:02:00 PM , Rating: 3
I'm not an English nazi, but I sea this confusion between the werds "lose" and "loose" all the time. "loose" means "not rigidly fastened or securely attached" as in loose change, a loose shew lace.


RE: So, any bets?
By JustTom on 6/28/2008 1:01:40 PM , Rating: 2
quote:
a loose shew lace.


quote:
Shew\, n. Show. [Obs. except in shewbread.]


I am an English Nazi. The word is shoe.


RE: So, any bets?
By geddarkstorm on 6/27/2008 12:20:37 PM , Rating: 3
If you actually read the article, you would have realized all of this was done with adult stem cells and growth factors :P.

Your body can repair every inch of itself, given the right signals, brain included--it's just the wound signal activates scar pathways instead of regeneration in humans unlike say salamanders and special strains of mice. Most likely this is done to conserve energy: it's a lot easier to grow scar tissue, which is just connective tissue, than an entire limb all over again!


Crazy times
By potatochief on 6/27/2008 4:03:18 AM , Rating: 5
Penis Enlargement, anyone?




RE: Crazy times
By oTAL (blog) on 6/27/2008 11:17:24 AM , Rating: 5
Are you the guy that keep mailing me?


regenerative super soldier
By pxavierperez on 6/26/08, Rating: 0
RE: regenerative super soldier
By Creig on 6/27/2008 7:57:18 AM , Rating: 3
Return to their productive CIVILIAN lives, idiot. Not everyone in the armed forces is a career soldier.


RE: regenerative super soldier
By andrinoaa on 6/28/2008 5:36:06 AM , Rating: 1
I have a far more uneasy feeling about the MILITARY doing far more medical research than the medical industry as a whole. Some thing stinks here. It just seems like word speak or an oxymoron. The killers are let loose to heal.!?!?!?!?!?!?


RE: regenerative super soldier
By Boze on 6/28/2008 3:33:38 PM , Rating: 2
The military doesn't exist to kill people, it exists to defend American people from threats both foreign and domestic. The only reason you didn't see major breakthroughs like this 65 years ago during World War II, or 100 years ago during World War I is because we weren't even close to having the necessary medical knowledge and technology.

I can't speak for other branches of the Armed Forces, but as a single job or "rating" as we say in the Navy, the largest group of people are Hospital Corpsmen, enlisted military members who perform various medical-related jobs. The Navy also maintains a large force of doctors of all types - cardiologists, dermatologists, surgeons, etc.

It would be a tremendous folly on your part to believe that every single person who joined the military was looking forward to killing someone, or was trained to mercilessly slaughter everyone in their path.


Today Skin, Tomorrow Limbs, The Day After…
By mkruer on 6/27/2008 2:31:18 AM , Rating: 2
So when will this be able to manufacture me the perfect girl?




By PAPutzback on 6/27/2008 9:43:15 AM , Rating: 3
She's in Vegas at 12th and ....


still far away
By James Wood Carter on 6/28/2008 5:43:53 PM , Rating: 2
Still years before it can be used to full effect, the so called pixie dust... thats just vague... how it causes growth is not clear and why it works isn't even know.
Making cells grow isn't difficult, the problem is regeneration of nervous tissue. if regeneration of nervous tissue is solved that would in my opinion be a landmark of regenerative medicine. This is great but just a first step




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