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Would you take pills to forget bad memories of your past? That's what new research from the University of Georgia may eventually promise.  (Source: Wired)
With new medicine you may soon be able to choose to wipe your memories -- but is it a choice you want to make?

Scientists are gaining impressive new insight into the brain and nervous system of late.  New experiments in neuron signaling could one day return movement to victims of paralysis.  And the next generation of computer controllers are already tuning in to our brain waves.  New technology even promises to reverse memory loss.

Now a radical new technology may dramatically alter life as we know it.  The Georgia College of Medicine has invented a chemical treatment that molecularly wipes traumatic or intense memories.  The chemical, successfully tested on lab mice, could be adapted to human physiology according to research and could one day be available to treat a variety of psychological ailments or even for elective use.

The approach targets a specific chemical in the brain.  This chemical, a protein, plays a crucial role in the formation of memories.  When recalling a specific painful event, a drug developed by the researchers overloads this mechanism, causing an excess of the protein to be produced.  This causes the brain to overload and chemically wipe all trace of the negative memory, without any apparent physiologically harmful side effects.

Scientists say that the treatment could be applied to humans and could one day wipe memories of traumatic events, a common cause of psychological problems.  While the researchers caution that memories are an important part of the learning process, they also acknowledge that some memories cause the mind more harm than good.

Dr. Joe Tsien, of the Brain and Behaviour Discovery Institute in Georgia comments, "First of all I should emphasise the methodology is not applicable to the human clinical situation yet.  However, it does suggest molecular paradigms which we can explore to perhaps achieve the same kind of effects in humans - but those are probably years or decades away."

He comments that war veterans, "often suffer from reoccurring traumatic memory replays after returning home".  A pill version of the memory wipe chemical could one day eliminate these traumatic flashbacks.

The new medicine bears uncanny parallels to the fictional movie "Eternal Sunshine of the Spotless Mind" in which Kate Winslet and Jim Carrey play two characters formerly in love who decide to wipe their memories of each other.

Dr. Joe Tsien warns, though, that if the treatment should ever be adapted for the human physiology, people should use it with caution.  He describes that most memories are useful, but a few can be harmful. "If one got a bad relationship with another person, hoping to have a pill to erase the memory of that person or relationship is not the solution.  (But) while memories are great teachers and obviously crucial for survival and adaptation, selectively removing incapacitating memories, such as traumatic war memories or an unwanted fear, could help many people live better lives."

The scientists used a special chamber to test the memory wipe.  A sound would play and mice would receive a mild, slightly painful shock.  The mice became alarmed when they would hear the noise.  Giving the mice the "memory protein" alpha-CaMKII, also found in humans, when the mice were not hearing the sound did nothing, apparently because the mice were not accessing the memory.  However, when the researchers played the sound and administered excess levels of the protein, the memory of the mice was wiped.  This was evidenced by repeated trials which showed the memory wiped mice to be unafraid of the sound when normal mice started panicking.

While many may be curious of how the new technology might affect life, Dr. Tsien reminds that it will take time to adapt to the human physiology.  He states, "No one should expect to have a pill do the same in humans any time soon, we are barely at the foot of a very tall mountain."

And yet, the new research takes the prospect of human memory wipes from the realm of fiction to ongoing research, and in doing so raises key social, moral, and ethical quandaries.

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Scary prospects
By AnnihilatorX on 10/27/2008 7:42:56 AM , Rating: 2
This can be turned by criminals to use it to wipe evidence of their traumatized victim?
For example, will such a drug be powerful enough to wipe the memory of a witness whom witnessed the murder and hence be exploited by the killer?
Perhaps a criminal can force-feed such a drug to the victim of rape?

RE: Scary prospects
By Hypernova on 10/27/2008 7:57:56 AM , Rating: 2
Until an actual human trial we will have no idea how deep and accurate this really it.

Bob may remember Jack robbing him but just can't recall how. Or something like that.

The real can of worms is when they start injecting memory...

RE: Scary prospects
By inperfectdarkness on 10/27/2008 8:13:09 AM , Rating: 3
not taken into account....

the recency of the memory. i'm sure something that happened in the past 24 hours is a lot more volitile than a memory from 24 years ago.

it would seem very delicate to extricate 1 negative memory from ages past without causing loss of other memories adjacent to it (either chronologically or categorically).

i remain unconvinced. may i remind you the human mind is the only animal species with a cerebral cortex; and that mind is infinately more complex than that of a purely instinctive creature--such as a labrat.

RE: Scary prospects
By BB33 on 10/27/2008 8:24:29 AM , Rating: 3
Dr: Do you know who you are?
???: No.
Dr: You are Subject01.
Subject01: I am Subject01.
Dr: Do you remember anything?
Subject01: No.
Dr leaves the room.
Dr: We have sucsess sir.
???: Now beging the retraining.

RE: Scary prospects
By BB33 on 10/27/2008 10:14:51 AM , Rating: 3
Well it seems that my point was missed as I was rated down on that post. So I will say it more clearly. Our memories are part of who we are good, bad/tramatic or other. If we start messing with them we run the risk of losing who we are. Just take a look at someone with advanced alzheimers, the cases that I have seen they are not the same person as before.

RE: Scary prospects
By chick0n on 10/27/08, Rating: 0
RE: Scary prospects
By someguy123 on 10/27/2008 11:49:03 AM , Rating: 2
actually i believe your comment was rated down because of the very awkward spelling errors.

RE: Scary prospects
By v1001 on 10/27/2008 11:56:35 AM , Rating: 2
"We want information, information, information."
"Who are you?"
"The new number two."
"Who is number one?"
"You are number six."
"I am not a number, I am a free man!!"

RE: Scary prospects
By InsaneGain on 10/27/2008 1:56:55 PM , Rating: 3
Actually the rat has a cerebral cortex. In fact, rats and mice share far more stretches of DNA with humans than dogs or cats. 85% of the DNA in humans and rats are the same and 90 percent of genes linked to diseases are the same. This is why rats are used for medical research.

RE: Scary prospects
By Beavermatic on 10/27/2008 9:57:35 AM , Rating: 2
It's only illegal if you get cought.

And if your smart enough to get around getting cought, more power to you.

RE: Scary prospects
By Samus on 10/27/2008 10:42:54 AM , Rating: 2
as far as i'm concerned this is a biological weapon and related research should be terminated.

it's one thing to understand how the brain works, its another to alter it in ways that could be used as a weapon. i can't believe this is actually happening.

RE: Scary prospects
By geddarkstorm on 10/27/2008 1:51:03 PM , Rating: 2
Don't worry Samus, the human mind is extremely more complex than a mouse, so it may not work at all. Moreover, notice that the mouse had to be actively undergoing the trigger for the memory (the sound) for this to work. There is only a small window of opportunity framed around when the animal is actively trying to remember.

RE: Scary prospects
By ThePooBurner on 10/27/2008 5:17:44 PM , Rating: 4
A good question is whether this is erasing the memory, or the trigger. There are some cases of trama that have multiple triggers, which is why it takes years of treatment and figuring out what all the triggers are and learning to control them/overcome them. They should try to have multiple triggers going at once and then see if they are jsut erasing one of them. there is countless numbers of tests that would have to be done before this could ever be thought of being used on humans.

Also, one thing i think of is that there is protien writing going on from the drug. It's not preventing anything, but altering. We have no idea if the trigger was just turned into something else (a different sound, a site, a smell?) that will manifest itself later on in an unpredictable way. This is very dangerous indeed.

RE: Scary prospects
By FITCamaro on 10/27/2008 5:11:34 PM , Rating: 2
It is spelled "caught".

And what a terrible attitude to have. Rapists will love this pill. They can wipe any memory of what they did from their victims if this delivers as promised.

RE: Scary prospects
By ggordonliddy on 10/27/2008 7:53:06 PM , Rating: 2
> It's only illegal if you get cought.

Or if you get caught.

RE: Scary prospects
By PhoenixKnight on 10/27/2008 2:38:45 PM , Rating: 2
While theoretically possible, that scenario is completely impractical. This would require a criminal to steal a hard-to-find, very expensive drug, force the victim/witness to take it, and hope it actually works properly.

Simply putting a bullet in the witness/victims head is so much cheaper, easier, and has a much higher chance of success. Why try new, exotic methods when the tried and true ones work just fine?

I'd like to remove all memories of WoW
By Spoogie on 10/27/2008 8:55:23 AM , Rating: 2
Where do I sign up?

RE: I'd like to remove all memories of WoW
By Bateluer on 10/27/2008 9:16:15 AM , Rating: 4
Our good friend alcohol can already handle that for you.

RE: I'd like to remove all memories of WoW
By xsilver on 10/27/2008 9:58:19 AM , Rating: 5
: Doctor will this treatment cause brain damage?

doctor: well technically, the treatment IS brain damage, we only charge you for it.

By TSS on 10/27/2008 8:04:30 PM , Rating: 2
: Doctor will there be any side effects?

Doctor: none that you will be able to remember.

seriously though if such a pill accidentally makes you forget more then you wanted to, how will you remember?

RE: I'd like to remove all memories of WoW
By chmilz on 10/27/2008 4:00:05 PM , Rating: 1
I'd like to remove all memories of the nasty girls I wake up next to that looked better the night before when I was wasted.

By foolsgambit11 on 10/28/2008 1:01:25 PM , Rating: 2
You mean a morning after pill for men?

By piroroadkill on 10/27/2008 8:49:12 AM , Rating: 2
To be honest I think this is a bad idea all round; if we start fucking with memories to such a fine degree, we begin to control minds and ruin lives..

Seems like these people should quit the research and do something else.

RE: Unsettling
By SlipDizzy on 10/27/2008 9:30:05 AM , Rating: 2
If this kind of research can lead to a better understanding of the brain then why would you want them to stop? I agree that tampering with memory can lead to dangerous situations, but I don't think it is their goal to produce an over-the-counter quick fix memory eraser. Maybe this research could lead to a cure for alzheimer... did you think about that?

RE: Unsettling
By curryj02 on 10/27/2008 10:36:30 AM , Rating: 2
I would agree that they shouldn't necessarily stop... but bad things have, and can, come as the result of the best intentions. I doubt the early pioneers of atomic research intended to create a weapon capable of destroying all life on earth many times over... or killing thousands of innocent Japanese civilians. Just something to always keep in mind.

RE: Unsettling
By SlipDizzy on 10/27/2008 12:36:43 PM , Rating: 2
I understand what you're saying, but I guess when one is pushing the limits of science, the results may not always be for their intended purpose.

"With Great Power, Comes Great Responsibility" --Uncle Ben to Peter Parker in Spider-Man.

RE: Unsettling
By derwin on 10/27/2008 4:46:45 PM , Rating: 2
Yeah... actually they did.

The first people to really do research on nuclear fission was the manhattan project.

RE: Unsettling
By Spectator on 10/27/2008 3:42:44 PM , Rating: 2
So what happens when us more complicated folk are supposed to be thinking about this Traumatic event..

Doctor says "your feeling sleepy.. now your all calm; and you are re-living your traumatic event"

Patcient thinks "wtf is this doc on. fook that sht. im thinking about those twins i de-bagged and fully radished; dam that sht was hot"

Doctor says "now forget those feelings and you will never have those again".

lol. you cant genetically modify physical growth.but you can mess with mental growth.. yes we are not shallow physical beings at all. GOOD JOB.

The next date rape drug?
By Lord 666 on 10/27/2008 8:25:18 AM , Rating: 2
I can see people with bad intentions using this out in the bar/club scene as the new GHB.

RE: The next date rape drug?
By FITCamaro on 10/27/2008 5:13:29 PM , Rating: 2
My thoughts exactly.

RE: The next date rape drug?
By foolsgambit11 on 10/28/2008 1:05:03 PM , Rating: 2
Except I'd imagine GBH or Ketamine would be a lot more reliable.

I don't think you'd have to worry about that. I'd be more worried about people using it to get vengeance. Slip them a pill, and they'll forget something. Doesn't matter what, really, you're still f-ing with their head.

Low level brain format
By kontorotsui on 10/27/2008 7:11:55 PM , Rating: 2
Some people indeed need a low level brain format, and to start again from the basics.

RE: Low level brain format
By FITCamaro on 10/28/2008 7:13:16 AM , Rating: 2
Hammers are much cheaper.

Beta Blockers
By Chemical Chris on 10/27/2008 8:19:09 PM , Rating: 2
This 'breakthrough' sounds eerily similar to beta-blockers, which have existed for decades. IIRC, they work in a similar way, by preventing the brain from storing memories. The general usage procedure is something like this: give a person the drug, wait for it to kick in, then have them recall the memory of interest (MOI), usually something unpleasant, and when the brain 'loads' the MOI into short term memory from long term memory, it is then unable to 'save' the memory to long term storage again after using it. But unlike a computer, loading the memory removes it from long-term memory, so with the drug in effect, the memory gets 'erased', as it is not re-saved. These drugs werent perfect, but did work most of the time.
I believe they are sporadically used. Lots of speculation the CIA and other spooky organizations use them for interrogation (nothing better than interrogating someone and them not remembering!)

So Im somewhat confused/underwhelmed by the article; is this a brand new discovery (new class of drugs), or just that the method of action of the old drugs has been deduced?

Chem C

RE: Beta Blockers
By JediJeb on 10/28/2008 4:33:13 PM , Rating: 2
Is that name correct? I hope it's not the same Beta Blockers I have taken to regulate heart my rate!

Tested on lab mice
By AnnihilatorX on 10/27/2008 7:39:44 AM , Rating: 2
How did they traumatize the mice?
No cheese for you! *sends* gigantic Aibo robot to crush the cheese.

RE: Tested on lab mice
By Brandon Hill on 10/27/2008 8:07:42 AM , Rating: 1
I think it wiped out the repressed memory that Mickey had of that drunken night with Pluto.

By ixelion on 10/27/2008 10:06:05 AM , Rating: 2
This might actually reduce certain crimes. Some psychopath's behavior can be attributed to child abuse, if we erase those memories they may never offend again.

By Ordr on 10/27/2008 11:00:05 AM , Rating: 2

Wanted in HR department!
By lemonadesoda on 10/27/2008 11:28:55 AM , Rating: 2
I want this!

1./ In the HR department. Fire someone? Just give them the pill and they won be coming back tomorrow.

2./ At the restaurant. Bad service? Here, have a free fortune cookie!

3./ Pre-divorce. Take this dear. Who are you? Get out of my house!

4./ Pepper spray additive. This is my drivers licence officer. SQUIRT. Why are you holding my drivers licence officer? Please give it back. Thank you.

5./ Old fashioned army remedy. Company returns from battlefield. Enjoy your dinner lads! Now then, it's your tour of duty next, off you go!

By Motoman on 10/27/2008 12:08:50 PM , Rating: 2
<nabs both and starts munching>

...whatever. Gotta get better than this.

Momma always said...
By ggordonliddy on 10/27/2008 7:55:30 PM , Rating: 2
Memories is as memories does. Life is like a box of dog feces that runneth red. You just gotta jam your hand in and pull out the whole steaming lot, if you want success and riches (and eat it to be sure).

Uh.. What was your name again...
By CyborgTMT on 10/28/2008 2:16:05 AM , Rating: 2
They already have a drug that does this, it's called alcohol. I did a clinical study over the weekend and trust me, I can't remember half of what happened!

"I'd be pissed too, but you didn't have to go all Minority Report on his ass!" -- Jon Stewart on police raiding Gizmodo editor Jason Chen's home
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