 (Source: tadamon.ca)
 Dr. Dan Peer (Source: aftau.org)
Delivers drugs directly into cancer cells
Scientists
in Israel have come up with a way to target cancer without damaging
healthy cells. Two researchers at Tel
Aviv University developed a nano-vehicle
that carries tiny particles of chemotherapy drugs through the body.
The drugs are released when the nano-vehicle comes into direct
contact with cancer cells.
Dr.
Dan Peer of Tel Aviv University's Department of Cell Research and
Immunology and the Center for Nano Science and Nano Technology and
Professor Rimona Margalit of the Department of Biochemistry and
Molecular Biology invented the tumor-targeting device.
"The
vehicle is very similar to a cluster bomb," explains Peer.
A
sugar molecule recognized by many cancer cell receptors is used to
create the outer coating of the cluster. The microscopic
nano-device is wrapped in this sugary coating -- which serves as a
trojan -- tricking the cancer cells.
"When the
nano-vehicle interacts with the receptor on the cancerous cell, the
receptor undergoes a structural change and the chemotherapy payload
is released directly into the cancer cell," said Peer.
The
direct release leads to more focused treatment against the cells. As
a result, this nano-vehicle can be used to treat various types of
cancer and increases the benefits of chemotherapy while reducing side
effects. Since the nano-vehicle is made from organic materials, it is
safer than current therapies and according to Peer and the materials
decompose once its function is complete.
Peer and Margalit are
said to be working with a pharmaceutical company in the United States
with expected trials to being within the next two years.
The
Tel Aviv team's breakthrough, published in the most recent edition of
the Biomaterials journal can be found here.
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