Primate-based Model/Bone Stem Cells Used to Regenerate Bladders
November 26, 2010 11:33 AM
Mesenchymal stem cells from bone marrow help regenerate damaged bladder smooth muscle cells
created a model
that is capable of using stem cells from a patient's bone marrow to regenerate their bladder.
Dr. Arun Sharma and Dr. Earl Cheng, both from the Feinberg School of Medicine at Northwestern University, have developed a medical model for regenerating the human bladder using mesenchymal stem cells (MSCs) from the patient's own
Previous research on stem-cell related bladder regeneration used animal models without human bone marrow MSCs, which had negative results when performed in clinical trials. But now, Sharma and Cheng have found that mesenchymal stem cells found in human bone marrow have similar physiological and phenotypic characteristics as bladder smooth muscle cells (bSMCs), which means that the MSCs can act as a replacement for bSMCs.
"For our research, we used a primate-based model, using the baboon bladder in conjunction with bone marrow MSCs to attempt partial bladder regeneration," said Sharma. "We found that the mesenchymal stem cells utilized throughout the study
retained the ability
to populate a surgically grafted area while remaining active 10 weeks after surgery."
In addition, the bone marrow cells were able to express important smooth muscle cell markers, which is required for the functional bladder's contractile cycles and continuous expansion. The primate-based model offered extended insight into the overall possibility of using human MSCs in partial bladder regeneration.
"This newly described bladder augmentation model represents a unique insight into the bladder regeneration process and provides strong evidence that
can be exploited for tissue engineering purposes," said Sharma. "The non-human primate bladder augmentation model established in this study will also further provide key pre-clinical data that may eventually be translated in a clinical setting."
With current information on bladder regeneration being extremely limited, Sharma and Cheng's research provides additional knowledge on the subject in hopes of eventually using MSCs in a hospital setting to regenerate damaged bSMCs.
"Advances in the use of bone marrow stem cells taken from the patient opens up new opportunities for exploring organ
, especially for bladder regeneration," said Sharma. "Several findings from our study have demonstrated the plasticity of stem cells derived from bone marrow which make them ideal for this type of work."
was published in
on November 23.
"Well, there may be a reason why they call them 'Mac' trucks! Windows machines will not be trucks." -- Microsoft CEO Steve Ballmer
New Artificial Environment Supplies Adult Stem Cells with Chemical, Mechanical, Electrical Cues
November 17, 2010, 1:39 PM
Researchers Announce First Clinical Trial for Stem Cell Therapy
October 12, 2010, 10:19 AM
Researchers Develop New Titanium Foam Bone Implants
September 23, 2010, 5:06 PM
Muscle-Growth Gene Therapy Raises Athletes' Hopes of Becoming Supermen
December 9, 2009, 9:24 AM
Cyber Hackers Threaten Security of Lifesaving Medical Devices
October 19, 2016, 8:09 AM
Innovative Neurotechnology in Sound Therapy Reduces High Blood Pressure and Migraines
October 16, 2016, 5:00 AM
Researchers Move Closer to Breakthrough Gene Therapy to Cure Sickle Cell
October 14, 2016, 5:00 AM
Keytruda: A breakthrough treatment to increase survival rates for lung cancer patients
October 12, 2016, 5:00 AM
CDC Warning about Record High Increases in 2016 for Polio-like Illness causing Paralysis
October 9, 2016, 5:00 AM
Hypertension in children impacts cognitive performance
October 5, 2016, 5:00 AM
Most Popular Articles
Car Insurance - The Hidden Discriminatory Practise
October 18, 2016, 5:00 AM
Problems with Windows 10 – Update Now
October 15, 2016, 7:30 AM
Is Razer Blade Stealth Laptop For You?
October 16, 2016, 5:00 AM
Tesla Event Pushed to Wednesday
October 17, 2016, 5:00 AM
Smart Technology Mood Collar To Understand Your Dog’s Emotions
October 17, 2016, 5:00 AM
Latest Blog Posts
Mac Users, Try this if Your Mac is Infected?
Oct 23, 2016, 7:00 AM
Tips to Prevent Smartphones From Overheating:
Oct 22, 2016, 5:00 AM
Nasa Flies Drones at Nevada Airport
Oct 21, 2016, 8:21 AM
T-Mobile Data Problems
Oct 20, 2016, 10:17 AM
Annoying Apple Watch Problems and How to Fix Them
Oct 20, 2016, 5:00 AM
Your Mail May Soon Be Delivered By Robot
Oct 19, 2016, 9:34 AM
2018 Jeep Wrangler Prototype Sells At Junkyard
Oct 18, 2016, 5:00 AM
Samsung Shines with Gold Edition Tablet
Oct 17, 2016, 9:24 AM
Tesla Hints Mysterious Product Debut for October 17th
Oct 16, 2016, 10:14 AM
Samsung Galaxy Note 7 Phones on US flights
Oct 15, 2016, 5:00 AM
Comcast Fined $2.3 Million For Unconfirmed Services Charged To Customers
Oct 14, 2016, 5:00 AM
“American singer / songwriter “Bob Dylan is awarded 2016 Nobel Prize in Literature.
Oct 13, 2016, 10:33 AM
Battery Defect in Medical Device
Oct 12, 2016, 5:00 AM
IBM Bolsters Social Services Sector With Technology Grants
Oct 11, 2016, 5:00 AM
Scientists Sound Alarm on Climate but US Still Toys With Skepticism
Oct 10, 2016, 5:00 AM
IMEX America Trade Show
Oct 9, 2016, 10:00 AM
Phone Wars – Google VS Samsung Free Gifts on Purchase
Oct 6, 2016, 5:00 AM
Member of Parliament’s opposition car exploded in Tbilist capital of Georgia
Oct 5, 2016, 2:52 PM
More Blog Posts
Copyright 2016 DailyTech LLC. -
Terms, Conditions & Privacy Information