Primate-based Model/Bone Stem Cells Used to Regenerate Bladders
November 26, 2010 11:33 AM
comment(s) - last by
Mesenchymal stem cells from bone marrow help regenerate damaged bladder smooth muscle cells
created a model
that is capable of using stem cells from a patient's bone marrow to regenerate their bladder.
Dr. Arun Sharma and Dr. Earl Cheng, both from the Feinberg School of Medicine at Northwestern University, have developed a medical model for regenerating the human bladder using mesenchymal stem cells (MSCs) from the patient's own
Previous research on stem-cell related bladder regeneration used animal models without human bone marrow MSCs, which had negative results when performed in clinical trials. But now, Sharma and Cheng have found that mesenchymal stem cells found in human bone marrow have similar physiological and phenotypic characteristics as bladder smooth muscle cells (bSMCs), which means that the MSCs can act as a replacement for bSMCs.
"For our research, we used a primate-based model, using the baboon bladder in conjunction with bone marrow MSCs to attempt partial bladder regeneration," said Sharma. "We found that the mesenchymal stem cells utilized throughout the study
retained the ability
to populate a surgically grafted area while remaining active 10 weeks after surgery."
In addition, the bone marrow cells were able to express important smooth muscle cell markers, which is required for the functional bladder's contractile cycles and continuous expansion. The primate-based model offered extended insight into the overall possibility of using human MSCs in partial bladder regeneration.
"This newly described bladder augmentation model represents a unique insight into the bladder regeneration process and provides strong evidence that
can be exploited for tissue engineering purposes," said Sharma. "The non-human primate bladder augmentation model established in this study will also further provide key pre-clinical data that may eventually be translated in a clinical setting."
With current information on bladder regeneration being extremely limited, Sharma and Cheng's research provides additional knowledge on the subject in hopes of eventually using MSCs in a hospital setting to regenerate damaged bSMCs.
"Advances in the use of bone marrow stem cells taken from the patient opens up new opportunities for exploring organ
, especially for bladder regeneration," said Sharma. "Several findings from our study have demonstrated the plasticity of stem cells derived from bone marrow which make them ideal for this type of work."
was published in
on November 23.
This article is over a month old, voting and posting comments is disabled
New meaning to bladder like a 3 year old
11/26/2010 2:03:29 PM
But now you can get them augmented. yay.
In all seriousness though, bone marrow for bladder augmentation almost seems like a step backward in usefulness (unless it goes the other way too) but at least after i post this, someone will correct me by saying how important this is.
Reputation , quality, absolute guarantee .
11/29/2010 8:28:40 PM
In order to meet Christmas, Some commodities have been, discount .In addition Buy $ 300 and receive a free glasses or a wallet, as a Christmas gift . welcome all friends to order. Reputation, quality, absolute guarantee. please log in:
. so what, move your mouse . bcgfd
"There's no chance that the iPhone is going to get any significant market share. No chance." -- Microsoft CEO Steve Ballmer
New Artificial Environment Supplies Adult Stem Cells with Chemical, Mechanical, Electrical Cues
November 17, 2010, 1:39 PM
Researchers Announce First Clinical Trial for Stem Cell Therapy
October 12, 2010, 10:19 AM
Researchers Develop New Titanium Foam Bone Implants
September 23, 2010, 5:06 PM
Muscle-Growth Gene Therapy Raises Athletes' Hopes of Becoming Supermen
December 9, 2009, 9:24 AM
Quick Note: Drone Loses Fight to the Death With Kangaroo
December 23, 2014, 3:28 PM
Campbell's Monkeys Found to Use Different Dialects to Describe Local Threats
December 22, 2014, 3:52 PM
Scientist Confirm Men are More Likely to Die in "Idiotic" Ways
December 17, 2014, 1:07 PM
Shoppers Surprised to Find Cards Against Humanity's Bullsh*t is Real Feces
December 16, 2014, 11:14 PM
Air Force Worries Hot Fuel Could Harm F-35, "Proactively" Paints Trucks Shiny
December 11, 2014, 9:06 AM
McDonald's is Testing Tablet-Based Burger Customization at 30 Franchises
December 10, 2014, 11:30 AM
Most Popular Articles
Miyamoto: Nintendo is Prepping Successor to Troubled Wii U
December 22, 2014, 6:28 PM
Amazon's Kindle Fire HDX 8.9 Drops to $299 (30 Percent Off) for a Day
December 22, 2014, 10:57 AM
Airbus A350 XWB Passenger Jet Takes Off, First Unit Delivered to Qatar Airlines
December 22, 2014, 1:22 PM
Microsoft, Google Back The Interview, North Korea Vows Attacks on America
December 24, 2014, 4:25 PM
Nokia's Sweet $250 Android Lollipop N1 Tablet is Rumored for Jan. 7 China Launch
December 24, 2014, 1:45 PM
Latest Blog Posts
Sceptre Airs 27", 120 Hz. 1080p Monitor/HDTV w/ 5 ms Response Time for $220
Dec 3, 2014, 10:32 PM
Costco Gives Employees Thanksgiving Off; Wal-Mart Leads "Black Thursday" Charge
Oct 29, 2014, 9:57 PM
"Bear Selfies" Fad Could Turn Deadly, Warn Nevada Wildlife Officials
Oct 28, 2014, 12:00 PM
The Surface Mini That Was Never Released Gets "Hands On" Treatment
Sep 26, 2014, 8:22 AM
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information