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  (Source: Reuters)
New treatment is badly desired as global diabetes rates soar

Aside from certain insects, all members of the animal kingdom require the peptide hormone insulin to regulate carbohydrate and fat metabolism -- and humans are no exception.  Diabetes -- an inherited or acquired disease in which a human's pancreas stops producing insulin -- was one of the first diseases known to man.

I. New Millennia, Same Old Diabetes Treatment

In 1921, having recognized that insulin regulated sugar metabolism, medical doctors began to obtain and purify insulin from various animal sources -- cows, pigs, horses, or even fish -- and injecting it into patients as a life-saving treatment for diabetes.  By the 1970s, purities of "99%" had been reached and production was dominated by large pharmaceutical companies.  In the 1980s, Eli Lilly and Comp. (LLY) became the first company to produce insulin from a non-animal source, using genetically engineered E. coli bacteria.  Other companies soon followed in suit.

But while the methods of production and impurity have improved -- and some new preventive therapies are on the horizon -- the treatment of diabetes still relies on the same unpleasant method of drug delivery -- an injection.  Pharmaceutical companies long believed this was the only way, as attempts to produce an "insulin pill" proved fruitless.

Insulin Injection
Diabetics today are treated the same way as they were in 1921, more or less -- with insulin injections. [Image Source: Wikimedia Commons]

The key technical challenge is that any pill to deliver insulin must survive a slew of digestive enzymes and the stomach's highly acidic environment.  The stomach naturally produces pepsin, and it "imports" trypsin/chymotrypsin from the pancreas.  All of these enzymes break down polypeptides -- a group of chemicals that produce insulin.  So surviving the stomach is one daunting obstacle.  And even if an insulin pill could survive, it would have to be able to selectively dump its contents once it reaches the small intestine.
Insulin
Insulin is a polypeptide, which makes it vulnerable to digestion by the stomach.
[Image Source: Wikimedia Commons]

Dr. Robert Ratner, chief science and medical officer for the American Diabetes Association (ADA), in a recent Reuters interview, remarks, "I'm not going to hold my breath on this one.  [An insulin pill] would be an important contribution to the therapeutic armamentarium. But there are still great limitations in our ability to get the insulin absorbed and control how much insulin gets absorbed."

II. Novo Believes in Diabetes Pill

But now one top drug maker -- and a small startup -- believe that an insulin pill is not only possible, but will be produced by the end of the decade.

On the corporate side Denmark's Novo Nordisk (OMX:NODO-B) has been the first company to publicly express a conviction that an insulin pill is possible.  Novo Nordisk has been experimenting with the concept in its labs for seven years now, and says that such a pill may be commercially available by the end of the decade or early next decade.

Diabetes pills
A batch of experimental insulin pills is finished at a Novo Nordisk lab. [Image Source: Bloomberg]

Internally Novo Nordisk refers to the hunt for an insulin pill therapy as a "holy grail" quest, indicating that it understands the difficulty and risk.

Novo Nordisk is building its attempt at this challenge upon new methods that allow insulin pills that survive the stomach and then route their contents from the small intestine to the liver.  The approach requires a lot of extra insulin as up to 90 percent is destroyed in transit.  Aside from the feasibility of delivery, this has led some medical experts to voice concerns that excess insulin in the digestive attract could trigger issues in local tissues.

Novo's diabetes research chief, Peter Kurtzhals, is a believer in the new approach, though.  He comments, "We've built technologies and we've seen from studies in animals and early human trials that this may not be as impossible as decades of research had indicated previously.  If you can [modify the insulin molecule's breakdown time to several minutes], maybe it's sufficient time for absorption to take place.  Risk is still high for this type of project. But the chance of success has gone up quite dramatically in our own minds compared to what it was originally."

II. Israeli Startup Begins Phase II Clinical Trials of Diabetes Pill

But a small Israeli company is ahead of Novo for now.  Worth a mere $50M USD Oramed Pharmaceuticals Inc. (ORMP) is putting up a spirited bid to become the first successful insulin pill maker.

Founded in 2006, the Jerusalem-based company's product is based on research work done at the Hadassah-Hebrew University Medical Center.  Most of the work was done by Professor Miriam Kidron, who now serves as Oramed's chief scientist.  Her son, Nadav Kidron is the company's CEO.

Oramed
Oramed's CEO shows off his company's star pill. [Image Source: Reuters]

He describes their journey, stating, "[My mother] is the chief scientist. I just went for the ride to do the business side.  My mother said it could be commercial but Hadassah won't be able to fund it.  I took the IP from Hadassah and started Oramed. Since then, we've been moving it forward.  If we give insulin earlier on, we're going to give the pancreas a rest.  We could reduce the complications, such as blindness and amputations.  There must be an oral insulin. This is going to be a huge market."

Skepticism from big pharma is not entirely unfounded Pfizer Inc. (PFE) poured a substantial amount of money and resources -- $775M USD according to one estimate -- into developing and testing nasal and oral sprays for insulin delivery.  The company tucked its tail and abandoned these efforts in 2007 after disappointing sales of its bulky "spray gun".

Exubera
Pfizer's Exubera, while achieving clinical success, flopped on the market.

But Oramed's unique pill technology -- which includes bundling a protease inhibitor to prevent digestion of the pill -- could be just the kind of disruptive thinking needed to make this unlikely product a reality.  Mr. Kidron is convinced his company is sitting on what will become a $7B USD market in oral insulin.

IV. Medical Community Adopts Wait-and-See Attitude After Past Failures

Oramed has begun Phase II clinical trials with human patients -- a middle stage in a drug development cycle.  

Oramed clinical trial overview
[Image Source: Oramed]

It plans to complete these trials on its own, and assuming success look to partner up to complete the arduous task of completing expensive Phase III trials and convincing regulators in the U.S. and abroad to allow the drug onto the market.  If his company succeeds, Mr. Kidron told Reuters that Novo is even one potential partner/buyer.  He comments, "Novo is in a different league from anyone else out there.  I look up to them."



Other researchers -- both in academic and corporate settings -- are testing a variety of other deliver mechanisms, including sprays (like Pfizer's failed attempt) and skin patches.  But oral delivery is particularly appealing, as patients are used to taking drugs orally and there's certain logistical advantages.

Those factors have some doctors cautiously optimistic about the technology.  Dr. Jason Gaglia, a top researcher at Harvard Medical School's Joslin Diabetes Center, comments, "If you could give it in an oral pill that is just hitting the liver, it would be wonderful.  If people take this pill at dinner time, they're not going to have this excess glucose production overnight and it will be really good for getting those morning blood sugars down."

Oramed

It may be years -- or even a decade -- before Oramed or Novo manage to bring the product to market, if they are succesful at all.  But an easier diabetes treatment is much needed as global diabetes are expected to rise from 285 million cases in 2010 to nearly 366 million cases by 2030 [source].  The driving factor is rising rates of Type 2 diabetes, which some research indicates can be caused by a so-called "Western diet" high in fat and simple sugar, as well as a lack of excercise.

An estimated 25.8 million Americans currently have diabetes, with as many as 7 million being unaware they have the disease.  Research has shown diabetes doubles the risk of death; it is directly the seventh leading cause of death in the U.S. and is indirectly tied to other leading causes of death including heart disease.

Sources: Oramed, Reuters



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Run Forrest Run
By mike66 on 10/10/13, Rating: 0
RE: Run Forrest Run
By mikable on 10/10/2013 10:35:42 AM , Rating: 4
Sorry, but I have to disagree. As a "type 2" that is not fat I am proof that you are incorrect. 5' 8" and 157 pounds, on insulin. Oh, yea I have a very active job and lifestyle too. Please don't throw absolutes around.

M


RE: Run Forrest Run
By Monkey's Uncle on 10/10/2013 11:09:24 AM , Rating: 3
Same here Mikable though I am an inch taller and 10 lbs heavier. But then I am also just under 60 years old too and have been diabetic for about 20 years (I was diagnosed with prediabetes while I was still training in Taekwon Do).


RE: Run Forrest Run
By mike66 on 10/10/2013 11:25:41 AM , Rating: 2
For 5'8 your weight is right at the upper end of the limit ( one pound and your over ), if you don't mind me asking whats your diet like ? a lot of processed foods ? and have you had your fat ratio measured ? I'm not trying to be offensive to you just curious as to maybe an indicator to a cause, being active in the modern world could be anything but may not be real exercise. Being hard lined and absolute about obesity is the only way to deal with it effectively, have you ever watched an episode of the biggest loser ? don't tell me that the trainers are treating the contestants nicely, more like tough love at best.


RE: Run Forrest Run
By Souka on 10/10/2013 12:01:50 PM , Rating: 2
Oh and there's one factor I don't see being discussed... genetics.

Does your family have a history of Type2? That alone can be the biggest factor in wether you're at risk for Type2.

I'm a type1 myself, have been for over 30 years. No family hisotry of type 1 or 2 (until after age 70+, then type2)


RE: Run Forrest Run
By Monkey's Uncle on 10/10/2013 12:35:39 PM , Rating: 2
Exactly souka.

While obesity can introduce diabetes earlier by raising your insulin resistance, it is not the only factor involved by a long shot. You pretty much need to be genetically predisposed to diabetes in order to get it.

Unfortunately there are a few that fail to understand there are other factors beyond simply being overweight/obese that can cause diabetes. Being overweight can indeed bring the the early form of diabetes (called prediabetes) on earlier and if caught at that stage, full blown diabetes requiring insulin can be postponed for a time - perhaps even for a decade or two. But if you are genetically predisposed to this degenerative disease, you will get it regardless of your weight & activity level.

Being overweight is never a good thing. it does increase your need for higher doses of insulin, but it is at the root of a huge number of other health issues - namely heart disease and stroke.


RE: Run Forrest Run
By Samus on 10/11/2013 2:11:04 AM , Rating: 2
While I agree with souka, genetics actually play a smaller factor in type 2 than environmental and food quality factors. Type 2 has increased at 10x the rate of population growth over the last century. If it were purely genetic, it would scale somewhat evenly with population growth.

The fact of the matter is our food is crap these days. Too much corn and gluten, too many preservatives, and too little fruit\vegetables. And it isn't necessarily the fault of the consumer. Quality food costs too damn much. Most people can't afford to shop at Whole Paycheck.


RE: Run Forrest Run
By vortmax2 on 10/14/2013 11:42:57 AM , Rating: 2
Nobody seems to be mentioning stress. That's a contributing factor as well when wrapped around the others.


RE: Run Forrest Run
By mikable on 10/10/2013 7:30:34 PM , Rating: 2
I eat a paleo diet. My activities include a 2 mile jog in the morning, and I bike most weekends.I am a landscape designer/installer. You install a 80 foot long brick wall and tell me about my fat ratio.... BMI is not an arcuate measure, it does not take into account muscle mass for one or bone structure. Do what works for you but don't toss that around as gospel.


RE: Run Forrest Run
By mike66 on 10/11/2013 1:22:33 AM , Rating: 2
It does look like you have a good life style for healthy living but the question I ask myself is " were you always that way? " Did you burn the bridge already. If it was not your previous life style then probably a virus or bacteria so yes my comments don't apply, that makes you a minority and my comment was to the majority.


RE: Run Forrest Run
By Monkey's Uncle on 10/14/2013 10:21:11 AM , Rating: 1
Bro, do I have to post your opening comment yet again?

And mike66 wrote:
quote:
Type 2 is caused by being fat plain and simple, studies have already proven that if you exercise and loose the fat then you can reverse the condition. So get of your butt and run. Stop wasting your life and the medical resources that should be devoted to others just because of your gluttony, which is one of the seven deadly sins (go figure).


In essence you say that ALL type 2 diabetics are that way because of lifestyle, gluttony and lack of exercise. That all of them are an unworthy drain on the medical system and should be shunned by society as lepers.

I have basically posted back to you, over and over again, that you are full of shit.

That an Atkins diet worked for you is great. koodos. I wish you a long and happy live. Just don't put everyone that has type 2 diabetes into the same bigoted bucket that you have placed yourself as a pre-diabetic . We are not you.

Stop assuming every one is like you and should live the same lifestyle as you. That lifestyle is a major cause of prediabetes and will, if left unchecked lead to incurable, full blown type 2 diabetes is a given. But it is by far not the only reason people get this disease (as I have also stated over and over).

We are not you and we are not willing/able to live your life.


RE: Run Forrest Run
By Monkey's Uncle on 10/10/2013 11:03:40 AM , Rating: 2
Thus speaks the trolling voice of stupidity.

Nice troll attempt.

Now post up the links to these studies that tell the cause of all Type 2 diabetes is being overweight. After all you are saying above that the only way you can get it is being fat, right? Where did you get your MD in endocrinology? Perhaps post some corroborating evidence by a endocrinology reports that also state that the only way to get Type 2 diabetes is by being overweight and that losing that weight will cure it (perhaps in the short term the symptoms are relived, but if you are genetically predisposed to Type II diabetes no amount of diet and/or exercise is going to stop you from reacquiring a need for insulin therapy).

Cane sugar? Seriously?
Um, do you eat bread? Rice? Potatoes? Carrots? Honey? I am not sure where you get the idea that the only way to introduce sugar into your bloodstream is via cane sugar (again your lack of education showing here). You really should talk to an endocrinologist before showing your total ignorance by posting this kind of tripe. Everything I mentioned is converted by your liver into glucose (sugar). Your body absolutely requires glucose as fuel. Without it, you die.

Don't take my word for it - talk to a real specialist about it ... I personally have on several occasions - this one: http://www.ourdiabetes.com/ a published endocrinologist that consult with.

BTW: Grats on losing some weight kid. I'm happy for you - it must've been hard for you to do. Just sad that your efforts didn't include that layer of fat surrounding your brain. Cheers!


RE: Run Forrest Run
By mike66 on 10/10/13, Rating: 0
RE: Run Forrest Run
By Monkey's Uncle on 10/10/2013 7:11:30 PM , Rating: 2
Not sure where you got the idea that you can't post links here. I did.

Do you even understand what function insulin performs in your body? Do you know how to check for high blood sugar levels or the dangers of not maintaining normal blood sugar levels? (hint: excess glucose getting stored as fat is the least of your worries!)

Please do talk to a practicing internal medicine specialist.

You know Smaller snippets taken out of context but using language like 'can not' instead of 'will not' or 'can' instead of 'will' does not make a definitive statement. That language does not state anything except of things that may or may not happen. There is not concrete language used here and thus makes the points nothing more than opinion.

For instance this quote:

quote:
Although the genes you inherit may influence the development of type 2 diabetes, they take a back seat to behavioral and lifestyle factors


There is nothing definitive being said here. This does not get into things like the genetic capacity of your ongoing pancreatic insulin production or its ability to last until you die at a ripe old age of 90. Nor does it get into the fact that the behavioral and lifestyle factors refer to the prediabetes condition. Prediabetes can be reversed - perhaps permanently if you have no genetic predisposition to diabetes. But today while you can reduce your need of insulin with exercise and diet, there is no cure for diabetes. If you have it, you have it for the rest of your life. Again, talk to a real medical professional that specializes in Diabetes. Don't depend of fuzzy studies that refuse to use definitive language and proof of their results. The results of studies require interpretation and that interpretation varies depends on the viewpoints of writes the reports.

quote:
Whether pre-diabetes expands into full-blown type 2 diabetes is largely up to the individual. Making changes in weight, exercise, and diet can not only prevent pre-diabetes from becoming diabetes, but can also return blood glucose levels to the normal range.


This does not say that diabetes (of any type) can be cured with changes in weight and exercise. Diabetes can not be cured. This is talking about prediabetes. Pancreatic function reduces with age. That is normal aging and also why you mostly see type 2 diabetes developing mostly in people 40-60 years old. Genetic conditions determine how fast that decline will be and by how much. Those with a predisposition to diabetes will have pancreatic function that declines faster and/or more abruptly than those without it. Once your it stops being able to produce the insulin levels your body requires, you need insulin. Losing weight and changing your diet will help reduce that need, but at the end of the day that pancreas will still continually degenerate until it stops working altogether.

THAT IS TYPE 2 DIABETES.

I have already said this, but it seems you need this repeated.

Poor diet, obesity and lack of exercise can accelerate the onset of diabetes. If this I do not argue. I DO argue your assertions that changing your lifestyle and diet will CURE DIABETES. It most certainly will NOT. What it will do is for those with PREDIABETES, changing lifestyle can reverse the PREDIABETES condition, but it will only defer the onset of diabetes in those who are genetically predisposed to develop it.

Prediabetes can be cured, not full blown diabetes. If it could I would be right there at the front of the line for that cure regardless of the cost.

If you are going to depend on fuzzy interpretations of studies, to gain your knowledge on this disease rather than discuss it with an internal medicine specialist, you are seeing only pieces of the picture, not the whole thing. Talk to an internal medicine specialist - I do regularly and have done so over the last 20 years.


RE: Run Forrest Run
By mike66 on 10/10/2013 9:31:57 PM , Rating: 2
quote:
Prediabetes can be cured, not full blown diabetes.

You've said it yourself, I did not say you could cure full blown type 2 diabetes. All illness has a tipping point when you go past the point of no return. In most cases people with type 2 they are doing it to themselves because they are over weight. Living to the ripe old age of 90 is an expectation not a certainty. You get to that age by looking after yourself and having some good luck, if you get to 60 then start counting in 10 year blocks and if you get 80 make it 5 year blocks and when you reach 90 go to one year blocks.
I have spoken to the experts when I was fat, I changed that and now I have my health back and have improved my chances of living longer but not only that I have improved my quality of life, western medicine is all about crisis situations not prevention which is a eastern medicine philosophy. So they Harvard School of medicine is wrong as well huh! Go have a doughnut it will make you feel better in the short term, there is no evidence that it will harm you in the long term.


RE: Run Forrest Run
By Monkey's Uncle on 10/11/2013 10:44:24 AM , Rating: 1
Here is what you said bro:

quote:
Type 2 is caused by being fat plain and simple, studies have already proven that if you exercise and loose the fat then you can reverse the condition. So get of your butt and run. Stop wasting your life and the medical resources that should be devoted to others just because of your gluttony, which is one of the seven deadly sins (go figure). I know because I was over-weight (fat) and started having the health problems myself, all you have to really do is stop putting unhealthy shit (you really shouldn't call it food) in your mouth and stop spouting that your fatness is caused by anything else but your own stupidity and laziness. I had one simple rule, if it contains cane sugar then don't eat it, read the ingredients on that packet,can or golden arches menu. I lost 40 kilograms and don't have any health problems that need treatment now.


See the bold part?

Look, I think it is great that you were overweight and dropped some of it. Good for you. That is not an easy thing to do especially when you get older. BUT it sure as hell doesn't make you an expert on the subject of diabetes unless you can link me to a picture of your MS in endocrinology. I am not an expert either BUT I do routinely discuss this with accredited experts with the appropriate medical degrees to back them up.

I agree with you that eating healthy and exercise will help you live a longer healthier life. That's a no-brainer. But it does not guarantee it you will any more than being overweight will guarantee that you will get type 2 diabetes. I know more than a few people over 300 lbs & over 50 that are not even prediabetic. I also know young people that are type 2 diabetic who don't have an ounce of excess body fat on them. Hell I was in the middle of training taekwon do for 5 years @ 3 classes/week when I was diagnosed as prediabetic at 42. I have a second degree black belt in TKD. So, did I do this to myself? I am type 2 diabetic on insulin. I eat reasonable meals as dictated by my dieticians. I go to my doctor every 3 months so he can track my hemoglobin A1C. I go to the hospital every 6 months to attend & present at the diabetes education clinic to others that have my condition.

There is absolutely nothing you can say to me that I have not already either heard from respected professions in the field of internal medicine and diabetes for almost 20 years.

So do us both a favor, talk to a doctor that specializes in internal medicine and diabetes. Don't tyake myu word for it and don't assume that because you have trolled a few websites and read a couple of studies that you know all there is to know about type 2 diabetes.

You will find that having a donut or a piece of pie once in a while is not such a bad thing.


RE: Run Forrest Run
By Monkey's Uncle on 10/11/2013 10:46:05 AM , Rating: 2
Sorry - typo -- please link a pic to your MD with endocrinology specialization ;)

Cheers!


RE: Run Forrest Run
By mike66 on 10/11/2013 1:41:25 PM , Rating: 1
quote:
You will find that having a donut or a piece of pie once in a while is not such a bad thing.

And that's exactly the kind of thing which makes people with your condition worse. I will do you the best favor in the world that any compassionate human being should even though most likely you will reject it because you haven't a clue about the why's and how's about your illness. I'll warn you now that you will have to manage your insulin intake as this will reduce the need for it so you will have to monitor your blood sugar levels properly with a doctor if you decide to do this yourself. Dr Eric Westman of Duke University has a dietary program that will at least reduce your need for insulin which may lead to you not needing it at all. This short video is the link you requested and it also gives you further links in the video to email him directly so this is not BS. http://youtu.be/dSLf4bzAyOM
He is a properly qualified MD and scientist.


RE: Run Forrest Run
By mike66 on 10/11/2013 1:46:36 PM , Rating: 1
PS Watch all of the video and do the research if you dare.


RE: Run Forrest Run
By Monkey's Uncle on 10/14/2013 10:28:44 AM , Rating: 2
I have. Perhaps you should watch it as well. Seems you missed some very important information in that video as it pertains to those with full blown diabetes (regardless of type). Perhaps once you have done that you will realize why a diet like this can be absolutely deadly to diabetics.


RE: Run Forrest Run
By Reclaimer77 on 10/12/2013 9:08:29 AM , Rating: 1
Are you going for the know-it-all asshole vibe, or does that come natural mike?


RE: Run Forrest Run
By Monkey's Uncle on 10/12/2013 9:20:25 AM , Rating: 2
I've given up trying to educate this guy. Done the best I can here between explaining it from the view of someone that has had to live with this disease for 20 years and directing him to speak to real health professionals that specialize in diabetes. Hell, I've even linked my endocrinologist's site for him.

It seems for some it is far easier to defend ignorance than to gain wisdom.


RE: Run Forrest Run
By mike66 on 10/12/2013 1:23:43 PM , Rating: 1
Are you still hurting from the last smack down Reblaimer ? lol.


RE: Run Forrest Run
By Monkey's Uncle on 10/12/2013 10:27:31 AM , Rating: 2
Atkins diets? You have got to be kidding me. You apparently are not and never have been diabetic. Otherwise you would have more sense to try and sell keytogenic diets to diabetics.

You are saying that based on this video an Atkins diet can cure type 2 diabetes? That has to be about the most moronic thing I have ever seen written at DT.

Do you have any idea what happens when someone with full blown type 2 diabetes goes on this kind of diet? We have little to no insulin production. It may be fine for a prediabetic to do that for a time (you can't keep a diet like that up without very severe consequences), but not someone on full blown type 2 diabetes. For someone with type 2 diabetes this pretty much an instant trip to keytoacidosis - you NEED insulin production to support atkins diets and you need constant medical monitoring to pull you off of it before acidic keytones can cause damage.

My brother in law was diabetic. On the same kind of advice as you and this fool in the video provided, he tried one of these diets. He was not well off so he could not afford the daily or even weekly medical specialist supervision this requires. Thus his nice, safe keytogenic Atkins diet that would be fine with those that have a fully functioning pancreas turned into keytoacidosis without him knowing it . Sure, he dropped 170 lbs within 3 months months and thought this was great. He also blew out his kidneys.

So sure, you might say his type 2 diabetes was permanently cured - we buried him a year and a half ago due to massive organ failures.

So spare me the preaching the greatness of keytogenic diets. For a diabetic that does not have constant ONGOING medical supervision, these diets can/WILL kill them in a big hurry.

I'm done trying to educate you. Either seek medical advice from a real professional that is not trying to sell his diets. Diabetics get proper dietary and advice from real professionals that are well informed of this degenerative disease.


RE: Run Forrest Run
By mike66 on 10/12/2013 1:14:38 PM , Rating: 2
quote:
with a doctor if you decide to do this yourself.

I quote myself but I already knew you were going to reject it for any reason or no reason at all. Dr Eric Westman is not killing people or otherwise the University supervisory would stop him , there is risk but that is no different from any medical treatment including the trial of a pill because people don't like a pin prick or the levels of insulin are not the best ( which will happen with the pill because it is not a natural bodily function ). Sorry to hear about your brother but really he was not doing it correctly and without doctor's supervision, anyone with common sense or a doctor would know that dropping 170lb in 3 month is foolishly dangerous. Fortunately to see a doctor in my country is free so when I did this I had the appropriate doctors supervision (I have earned enough money so that does not matter to me anyway), I had cirrhosis of the liver and pancreas, cancer ( numerous tumors including one the size of a tennis ball in my brain ) and was extremely fat with fatty intrusion around all my organs (kidneys and heart). I was told that I had to have insulin support and that it was going to be for the rest of my life (which wasn't going to be that long anyway) even if I lost the weight it was expected that I remain on insulin support. It was my life style that caused most of those issues and 3 whole body CT scans (doctors recommended them) and my trust in the medical system / doctors that caused the cancers (because my tumors were radiation induced chemo therapy would not work). I decided that any risk was acceptable to get my health back, I looked at every treatment possible and researched everything, right down to the cellular level, conventional medicine as well as the hippy herbal treatments. I made choices mostly good, some bad and learned and changed those things that did not work and had different stages with different requirements. I rolled the dice big time, risked everything on 2 facts, that specialist's don't know everything - that to some extent they were ignorant of complementary functions of the whole body and that conventional medicine and treatments are largely money driven. I am now cancer free (without surgery), not fat and have no health issues apart from some dandruff. I am either the luckiest person on the planet, the recipient of a miracle, have an IQ of a 140+, or maybe I learned something important about human health.
Any way I don't care what you do as I know you will cling to your view point till deaths end, it would be to much of a risk for you. Have that sugary food and be happy, don't forget that extra insulin shot.


RE: Run Forrest Run
By Monkey's Uncle on 10/14/2013 9:55:12 AM , Rating: 2
So, now you are saying an Atkin diet cured cancer?

Good luck to you.

If what you are saying is true, I sincerely hope you make it to my current age. Good luck.

Done.


RE: Run Forrest Run
By mike66 on 10/14/2013 12:24:05 PM , Rating: 2
No, but it does compliment certain aspects of my health lifestyle, and I don't use all the atkin diet now ( I used it in the beginning to get rid of my extra body fat and now have modified the basic diet to maintain proper body weight/fat ratio ), too maintain my now cancer free status I now use ground Turmeric, Ginger and Garlic. Too rid myself of cancer in the beginning I used the afore mentioned plus Broccoli and cauliflower - to create a mix of very strong DAC compound. Cauliflower is recommend by renal specialists to help with prostate cancer. Extract of Turmeric has been trialed as an alternative to chemo therapy because it "wakes up" the mitochondria in cancer cells which then suicide the cancer cell. I looked at all the Hippy herbal Therapies ancient and modern and whatever was mentioned as having an effect in western medical trials and chose them as basis for my own treatment. I ground, sliced chopped,shredded, fried and boiled, exercised (no running as brain aneurysms are very common with brain tumors)and even watched what time of day I took some of my extracts and food. That's so brief and by no means cover what I have done. One large aspect I looked at was Sugar and how it reacts to the whole body (it had already made me fat) and I had to take it out of my diet completely (except some fruit sugar used in delivbery methods) because it feeds cancer (diabetes was a minor aspect), all cancer cells use three times the amount of glucose of normal cells so flooding my body with glucose was causing my cancer to grow. I have had some very interesting thoughts on diabetes in my own therapy. Diabetes 2 was just about none existent before the 1970's. That's why we used to call diabetes 1 - Junior diabetes. It's prevalence grew with the inclusion of sugars (corn, cane and others) in everything we eat. Eating fat is not causing heart disease, eating sugar is, it turns to fat when not used by the body. I could go on and on about some of the things I have discovered on my journey. I go to my doctor now and he just sits there and scratches his head because he is not allowed to recognize that what I have done is possible. I past my specialist's doctors death date three and a half years ago, when I reach year four I am going to publish an extensive health care book on what I have done and I have my original medical reports and scans to back me up. I past my specialist's doctors death date three and a half years ago, when I reach year four I am going to publish an extensive health care book (using my own money) on what I have done . I intend to give it away to anyone who can't afford to buy it and let everyone judge for themselves. I'm not that young, 48 if you must know.


RE: Run Forrest Run
By mike66 on 10/14/2013 12:31:24 PM , Rating: 2
Ooops repeated that last paragraph, I better find me a good editor. Take a risk if you are unhappy with the status quo as quality far out ways quantity.


RE: Run Forrest Run
By Uncle on 10/11/2013 1:31:45 AM , Rating: 2
Agree: New treatment is badly desired as global diabetes rates soar...Stop ingesting all the sugar, fat and salt. Try the taste test. Stop total intake of salt for one month then go to your favorite restaurant and have some soup, its like getting a mouthful of sea water.


RE: Run Forrest Run
By Monkey's Uncle on 10/12/2013 10:32:30 AM , Rating: 2
Agreed.

Reducing carbs and salt is wise advice for anyone - not just diabetics.

Added salt is not necessary since the basic foods we eat naturally have enough for our needs. However some fats, carbs and proteins are required for a good balanced diet. You just need to balance them correctly. A registered dietitian can help you with that balance.


A problem of control.
By Monkey's Uncle on 10/10/2013 10:32:02 AM , Rating: 2
It is great if they could find a less invasive way of introducing insulin, but how on earth would you control the insulin dosage with pills?

Insulin is different than most drugs in that you have to control the dosages right down to extremely small 'units' (there are 100 units per ML of insulin). The dosage varies depending on conditions so the diabetic person must be in in full control of how much insulin he/she takes given the circumstances (how much activity planned, current blood sugar level, how many & what kind of carbohydrates to be consumed in a meal, stress levels). This control is right down to the 'unit' level.

The fact that insulin must be injected has always been a problem. The procedure requires medical supplies (syringe/pen, needles, sterilization, etc) and can be unsettling to others that happen to catch a diabetic injecting him/herself.

Having alternate ways to introduce insulin into the body would be a real boon for diabetics. The biggest problem to overcome imho is that control issue. Not enough insulin, and the diabetic's blood sugar remains too high. Too much insulin, even as little as 5 units too much, is extremely dangerous as it can and often does cause unconsciousness, coma & death.




RE: A problem of control.
By Guspaz on 10/10/2013 12:41:13 PM , Rating: 2
Separate dosages and multiple pills. Dosage differences of 5 units matter for somebody who is taking a 14 unit dose, but not as much for somebody taking a much larger dosage.

For somebody doing a dosage between 0 and 20 units, for example, then you might give them pills of 1 unit, 5 unit, and 10 units. The worst case there would be 6 pills (19 units). You would have to balance between how many different dosage levels of pills you give somebody versus the number of pills you want them to swallow.


RE: A problem of control.
By Monkey's Uncle on 10/10/2013 6:10:23 PM , Rating: 4
Speaking form direct personal experience here. 5 units can make a big difference even at realistic dosage levels for those that keep tight control on their blood glucose (between 4.0-5.9 mmol fasting). A 5-unit overdose can easily leave you unconscious.

Without actually disclosing my own personal dosages (nobody's business here) I would need to consume a minimum of 14 pills for a single dose of my nightly glargine insulin. Not feasible. And I certainly would NOT want to try and swallow a single pill that contains 50 or 100 units of insulin!


Risk of Death?
By Nephiorim on 10/10/2013 9:26:44 AM , Rating: 5
quote:
Research has shown diabetes doubles the risk of death

I would imagine the risk of death is always 100%. It's more of a certainty for everyone.




RE: Risk of Death?
By Runamok81 on 10/10/2013 9:51:00 AM , Rating: 2
quote:
I would imagine the risk of death is always 100%. It's more of a certainty for everyone.


Ah yes, that is technically correct. The BEST kind of correct.


basil
By zeppster on 10/10/2013 10:41:46 AM , Rating: 2
I am diabetic and take 2 types of insulin. If this pill could take the place of basil insulin that would be one less shot a day and one less type of insulin I need.
I have the type of diabetes brought on by a virus... They released the 'cure' for my type but only if caught early on.
Hoping they find it to be effective for me too at some point.




RE: basil
By Monkey's Uncle on 10/10/2013 11:23:31 AM , Rating: 2
This seems to be liver-driven. Not sure how this will effect insulin production by the pancreas (or if it will even cause earlier failure of that organ).

Would like to see some more information about it beyond this little video.


insulin pill therapy as a "holy grail"
By Phoque on 10/10/2013 5:09:41 PM , Rating: 2
Really?

If I was diabetic, the holy grail would be some gene therapy or technology that would fix my problem at the root. So I wouldn't need to take any medication ever.




By BZDTemp on 10/11/2013 6:31:02 AM , Rating: 2
And where would the business value be in that?

It is much more lucrative to make medication that manages a disease than making one that cures a disease.

Now I'm not saying that medical companies are all about the money and that no effort is going into finding cures, but the funding for managing chronic diseases like diabetes is much higher than the funding for curing such diseases.


The other way around
By BernardP on 10/11/2013 5:32:18 PM , Rating: 2

It's not being fat that causes diabetes. It's diabetes that makes people fat. And it's too much carbohydrates that makes some people diabetic.

For a full explanation of this subject, I highly recommend this well-researched book: Gary Taubes: Good Calories, Bad Calories

http://www.amazon.com/Good-Calories-Bad-Controvers...




BDS
By NanoTube1 on 10/11/2013 6:06:58 PM , Rating: 1
I hope the arabs and anti semites around the world are going to boycott this pill as well. Their diabetics don't need no zionist medicines. </Sarc>




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