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While toxic, the addictive compound nicotine found in tobacco smoke may promise to treat many of the most debilitating symptoms of the mental illness schizophrenia  (Source: AOL Living)
Smoking is still a very dangerous way to get the chemical, though

Smoking may cause cancer and brain damage -- and even damage electronics -- but one of the primary chemicals in cigarette smoke, nicotine, holds promise in improving the lives of those with the mental illness schizophrenia, according to a new medical study.  Nicotine is a stimulant, similar to caffeine, but more potent.  It is also a procarcinogen, as the liver converts it in small quantities to carcinogenic derivatives.

The new study, led by Ruth Barr, a psychiatrist at Queen's University in Belfast, Northern Ireland, looked at the effects of nicotine on patients' cognitive function, such as planning and memory in social and work settings.  According to Dr. Barr, improvement cognitive function is the most critical need for those suffering from the disease.  She states, "We know that patients that do better in the long term are those with good cognitive function rather than improvement in any other symptom."

Prior to the study only beneficial effects of nicotine being used to overcome smoking withdrawal symptoms were used.  The new study, involved dosing the patients with nicotine.  Describes Dr. Barr, "(W)e would ask participants to go without a cigarette for 12 hours and then provide a single dose of nicotine and measure cognitive function."

Intriguingly rather than just showing less symptoms of nicotine withdrawal, patients also showed improvement in brain function, including less impulsive behaviour and better levels of attention, both of which are unrelated to nicotine withdrawal.  Dr. Barr says more research is needed, stating, "We don't yet know whether these effects persist or not and if those improvements have any impact on daily life, for example, remembering shopping lists or conversations."

A nicotine based patch or nasal spray could be used as a treatment.  States Mohammed Shoaib, a psychopharmacologist from the University of Newcastle, not associated with the study, "Now, the rationale is to provide a more strategic treatment in the form of a skin patch or nasal spray to avoid the toxins in cigarette smoke. This is the way to go."

Cigarette smoking lowers life expectancy by approximately 10 years, due to it increasing the risk of heart disease, certain cancers, and brain damage.  Nicotine is highly addictive, and, as mentioned, is a procarcinogen.  One possibility is to develop schizophrenia drugs derived from nicotine -- so called "nicotine agonists" -- which would bind to the same brain receptors (and have the same effect), but would not be converted by the liver into carcinogens.

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Nicotine supplements?
By ZimZum on 8/7/2009 12:53:31 PM , Rating: 2
Nicotine has numerous positive effects on the brain. Its the delivery system (tobacco) thats bad for you.

RE: Nicotine supplements?
By JasonMick on 8/7/2009 12:56:34 PM , Rating: 5
And its carcinogenic byproducts...

Your liver converts it to cancer-causing compounds, as I mention in the article. Part of why smokers have a higher risk of certain cancers.

RE: Nicotine supplements?
By SiliconJon on 8/7/2009 1:22:53 PM , Rating: 2
Now to grab some marijuana derivatives and meld them into such a study, as studies have suggested pot smokers more likely to suffer from schizophrenia. While such articles try to imply marijuana to be the cause, I think they fail to see the more likely possibility that pot smokers who suffer from schizophrenia are easing their symptoms with the pot smoking.

RE: Nicotine supplements?
By GlassHouse69 on 8/7/2009 2:24:22 PM , Rating: 1
smoking pot has 3-5x higher chance of emphysema than smoking ciggarrettes, if on a daily basis. Tar is huge in pot, and its increased as the years go on in the making of it as the resin is where the punch is and so is cultivated for that.

it also impairs using machinery and driving a car for 30 days or longer. I know that these two things are not very important to do in 2009. I mean seriously, who needs to drive or use technology? And really, emphysema is so worth it, it's so awesome.

RE: Nicotine supplements?
By Ammohunt on 8/7/2009 2:30:39 PM , Rating: 4
it also impairs using machinery and driving a car for 30 days or longer.

Yeah becasue its hard to operate machinery since it take two hands to generate a hit off of a Steam Roller.

RE: Nicotine supplements?
By JonB on 8/7/2009 2:51:58 PM , Rating: 2
Sure would like to see the reference for that claim about driving. I searched and only found articles claiming impairment lasting a max of 48 hours for extremely heavy users, 12 to 24 hours for light users.

RE: Nicotine supplements?
By Cheesew1z69 on 8/7/2009 3:48:29 PM , Rating: 2
it also impairs using machinery and driving a car for 30 days or longer.
That's bullshit......

RE: Nicotine supplements?
By quiksilvr on 8/7/2009 6:16:39 PM , Rating: 4
Which is why using a bong is much better since its traps the water soluble materials from the tobacco or cannabis.

RE: Nicotine supplements?
By xRyanCat on 8/7/2009 6:38:24 PM , Rating: 4
That's completely incorrect. Marijuana can be metabolized, passed through the fat, and completely burnt out of your system in way less time than that. The actual mental effects never last more than 48 hours and typically last anywhere between 2-12 hours.

Your ignorance is showing.

RE: Nicotine supplements?
By 67STANG on 8/7/2009 6:42:19 PM , Rating: 2
Someone bought into reefer madness.

How exactly does it impair using machinery or driving a car for 30 days or longer? As far as I know, you'd have to do it twice a day for it to impair you for 24 hours... I mean seriously.

How many "stoned driving" incidents do you hear about? If anything, stoned drivers (assuming they have the motivation to make it to a quick-e-mart for a twinkie) drive slower and more carefully than anyone else.

RE: Nicotine supplements?
By deeznuts on 8/10/2009 4:35:38 AM , Rating: 2
Driving high can definitely be dangerous. I don't partake anymore but when I did (I'm talking 10 years ago ... don't worry I'm in So Cal so only the kind here) me and my buddy were driving back home after a night of kicking it. both pretty damn high. Summertime, no classes, windows rolled down blasting some music. Yeah good times. Anyway, we were so high we didn't realize we were doing 55 on the freeway. A Semi honks at us because we were going to slow and he was riding up on us pretty quickly (no idea why he felt the other 3 fucking lanes were not good enough),

Anyway, yeah, dangerous. 55 in a 65 is not safe!

RE: Nicotine supplements?
By spread on 8/7/2009 7:28:23 PM , Rating: 2
Impairs for 30 days or longer?? That must be REALLY good stuff. Out of this world good.

And just so you know, you don't need to dip the plant in tar before smoking it.

RE: Nicotine supplements?
By SiliconJon on 8/10/2009 4:21:35 PM , Rating: 2
My name is Abby and I am a retard

RE: Nicotine supplements?
By SiliconDoc on 8/14/2009 7:33:12 AM , Rating: 2
Who really cares what your crappy stat carping blabs about ? Sometimes I think we're creating a gaggle of the dumbest retards who think they know something, because they cite some torture artists BS they choked out with a chunk of the billion free government bucks grants.
Case in point, look what TARD LADY did for this study ! :
" The new study, involved dosing the patients with nicotine. Describes Dr. Barr, "(W)e would ask participants to go without a cigarette for 12 hours and then provide a single dose of nicotine and measure cognitive function."

Intriguingly rather than just showing less symptoms of nicotine withdrawal, patients also showed improvement in brain function, ....
So let me get this straight. They took their mental patients, smokers, and took their ciggies away for 12 hours - now that drives a NORMAL person moonbat INSANE, ready to rip anyone's head off that farts in their direction.
After 12 hours of sustained TORTURE, they DOSED the driven further insane lunatics ( they don't say if that is a shot or a patch or a smoke, but you can bet it AIN'T a smoke - as then the Dr. Mengelas would be accused of "causing cancer" by the TARDS who passed over the 12 hours of inhumane TORTURE because they can't think straight aynway, with or without nicotine ) -
and after dosing those lunatics back up to par, they found the 12 hours of TORTURE resulted in "improved brain function and attention".
Now, you tell me, if someone just tortured you for 12 hours straight, then jabbed you with a needle or slapped some patch on you, would they have your attention ?
I hope I made my point. If you are TOO STUPID to follow, or have your INSANE "controlled study" excuse handy, don't bother replying.

RE: Nicotine supplements?
By Parhel on 8/7/2009 3:38:44 PM , Rating: 3
While such articles try to imply marijuana to be the cause, I think they fail to see the more likely possibility that pot smokers who suffer from schizophrenia are easing their symptoms with the pot smoking.

I doubt that highly. If anything, it's more likely that there are other contributing factors common to both schizophrenics and drug abusers such as antisocial tendencies, predilection to addiction, lack of motivation, disorganized thinking, and little overall structure to their lives.

RE: Nicotine supplements?
By TSS on 8/8/2009 7:41:47 AM , Rating: 2
heh... according to how i see the world you've described 90% of the human race right there ^^'

but anyway, here's a little known fact about pot i learned only recently myself:

did you know it had 2 active substances?

THC, we all know. it gets you high. but there's another, CPB, that's also found in the cannabis plant. and guess what, it's an anti-phsychotic . and a potent one at that.

appearantly that's the reason why pot has become stronger too, they've found ways of limiting the CPB content.

it might very well be schizophrenics react more heavely to CPB and thus find calm by using pot. it might very well be that somebody who's only got minor problems reacts to the THC and gets pushed towards schizophrenia.

in any case we need a lot more research to be clear on this, and not just some government funded report with pre-determined conclusions.

RE: Nicotine supplements?
By William Gaatjes on 8/8/2009 7:26:24 PM , Rating: 2
CPB, that's also found in the cannabis plant. and guess what, it's an anti-phsychotic . and a potent one at that.


It seems to have more favourable qualities. Living on veggies is good for you...

CBD alone is not intoxicating, but displayed sedative effects in animal tests. It may decrease the rate of THC clearance from the body, perhaps by interfering with the metabolism of THC in the liver. CBD does not appear to affect either the CB1 or CB2 receptors. Some research, however, indicates that CBD can increase alertness. Medically, it appears to relieve convulsion, inflammation, anxiety, and nausea, and to inhibit cancer cell growth. Recent studies have shown cannabidiol to be as effective as atypical antipsychotics in treating schizophrenia. In November 2007 it was reported that CBD reduces growth of aggressive human breast cancer cells in vitro and reduces their invasiveness. It thus represents the first non-toxic exogenous agent that can lead to down-regulation of tumor aggressiveness. It is also a neuroprotectiveantioxidant.

Not entirely unprejudiced :

RE: Nicotine supplements?
By SiliconJon on 8/10/2009 4:31:29 PM , Rating: 2
I get what you're saying and would agree that common factors are more likely, though I would consider your list to appear more like effects that causes, or perhaps segues...though I could easily see this turn into a chicken & egg argument.

RE: Nicotine supplements?
By S3anister on 8/7/2009 8:48:32 PM , Rating: 2
studies have suggested pot smokers more likely to suffer from schizophrenia.

Can you provide a link to a legitimate, peer-reviewed article supporting this claim?

RE: Nicotine supplements?
By Parhel on 8/7/2009 9:30:45 PM , Rating: 2
The following link contains further links to about 30 such articles.

I'll be honest, I only briefly looked at a few. But what's interesting in light of the original post is that researchers have most certainly considered the possibility that marijuana use, like nicotine, is "self-medication" but the evidence rules against that hypothesis.

RE: Nicotine supplements?
By 1337cookie on 8/9/2009 1:29:30 PM , Rating: 2
Not likely. I suffer from drug induced psychosis when I've had canabis, the overall effects had me completely irrational for 2 months and the full effects didnt fade for around 5 months. THC is a psychotic drug it reaps havoc with normal brain function most people recover fine and continue to function normally after a few hours.
You might notice if you have ever had really strong MJ or hash you might get the paranoia or reduced thought paths making you unable to think normally and being stuck thinking about something. These are symptoms of schizophrenia. Psychotic drugs and Schizophrenia do not mix.

RE: Nicotine supplements?
By ZimZum on 8/7/2009 1:33:55 PM , Rating: 1
"Nicotine itself is not carcinogenic, according to the International Agency for Research on Cancer"

Smokers have high risk for cancer because the compounds in Tobacco are carcinogenic. Nicotine on its own has never been shown to be a carcinogen.

RE: Nicotine supplements?
By Pudro on 8/8/2009 5:00:02 PM , Rating: 2
Learn how to read. It is not being called a carcinogen. It is being called a procarcinogen. Both the article and the post you are replying to even give you clues as to what that means if you are too lazy to look it up yourself.

By inperfectdarkness on 8/7/2009 4:46:34 PM , Rating: 2
i'm amazed we had to research this. i could have told you that. i used to work in mental health. the % of patients who used narcotics, nicotine, or alcohol is stupefying. something along the lines of 3/4 people.

self medication is a VERY powerful motivation. i can't begin to describe how many times we had to prevent patients from inventing new & creative ways to get a nicotine fix. usually a daily occurrence.

RE: Nicotine supplements?
By JasonMick on 8/7/2009 12:57:33 PM , Rating: 2
P.S. You don't happen to work for Malboro, do you? ;)

RE: Nicotine supplements?
By wuZheng on 8/7/2009 1:14:56 PM , Rating: 2
Linking to a smoker/tobacco advocacy site... to support the benefits of nicotine, well thats going to help your argument a bunch.

Nicotine's benefits are therapeutic and like "medical" marijuana aid in relieving symptoms of certain conditions. Nicotine also has real negative effects on the human body. Many of which have been documented more thoroughly by many medical journals (Google is your friend).

Nicotine is a chemical that the human body does not have a natural receptor for, it merely bonds itself to a receptor for another chemical and effectively replaces it, your body soon becomes "dependent", which is part of the reason one gets addicted so easily.

Putting foreign elements in one's body is something usually cautioned against and for good reason. Foreign elements will upset the body's natural chemical balance in ways that no one can accurately predict. However, I don't think many of the results of upsetting one's natural body chemistry are positive.

RE: Nicotine supplements?
By myhipsi on 8/10/2009 8:57:13 AM , Rating: 2
Nicotine is a chemical that the human body does not have a natural receptor for, it merely bonds itself to a receptor for another chemical and effectively replaces it, your body soon becomes "dependent", which is part of the reason one gets addicted so easily.

How about the Nicotinic acetylcholine receptor?

Certain drugs have specific receptors in the brain, nicotine being one of them. Other examples:

Cannabis - Cannabinoid receptors (CB1 & CB2)
Opiates - Opioid receptors (Delta, Kappa, mu, Nociceptin)

RE: Nicotine supplements?
By kattanna on 8/7/2009 1:46:03 PM , Rating: 3
if you really want to get the nicotine, why the heck choose cigarettes? they are horrible

have a good cigar instead!

RE: Nicotine supplements?
By Regs on 8/7/2009 2:06:33 PM , Rating: 3
I quit about a year ago. Though I remember smoking slowed my brain activity down more so than stimulate it. Also, it's hard to focus on anything when all I could think about was grabbing a smoke and a coffee through out the entire day.

RE: Nicotine supplements?
By GlassHouse69 on 8/7/2009 2:31:46 PM , Rating: 1
Smoking destroys brain cells. Are people freaking retarded? who on earth made such a pathetic study without including this detail that all psychiatrists understand. Carbon Monoxide kills brain cells. depletion of oxygen from smoking is harmful to brain matter. No, not in a huge way, but it's a consistent effect everytime you inhale a cig.

Also, the effects of smoking on psych patients is terrible. It supports addictions, it contributes to their physical illnesses. Do you know that many of the drugs they take cause weight gain? 1 can even trigger diabetes without the weight gain. At a day treatment center, those who smoke ALL have copd. Their lives suck. They cannot do sports, they will die earlier from the disease, but most importantly, they will die slowly for 20+ years. Nicotine in a pill form has enormous side effects, it is highly toxic on the body. You may not have any genetic predispositions to cancer and never get cancer. From orally or via patch, the toxins in your body are massive enough to disrupt thinking, muscle response, give organ damage, nicotine really sucks as a chronic poison.

A cigar once in a while seems to only give the possibility for mouth and lip cancer. (throat takes a LONG time, mouth and lip and gum can be within a few weeks!)

RE: Nicotine supplements?
By Starcub on 8/7/2009 6:58:45 PM , Rating: 2
I'm not surprized that they came to the conclusion they did in this study. It sounded like they attempted to measure the effect of nicotene on people who already smoked or who were already impaired to begin with.

I know that smoking also causes chemical changes in the brain that negatively effect mood. It sounds to me like the topic of this article was misleading. There is nothing in it that suggests that nicotene is beneficial to cognative function in non-smokers. However, there is plenty in it to suggest that nicotene is bad for you period.

RE: Nicotine supplements?
By GlassHouse69 on 8/7/09, Rating: 0
RE: Nicotine supplements?
By Lord 666 on 8/7/2009 2:33:39 PM , Rating: 3
So how long have you smoked?

RE: Nicotine supplements?
By SiliconDoc on 8/14/2009 7:58:06 AM , Rating: 2
That one washes it's hands 25 times a day from the fear of germs as well.
No worries, Obama will have it employed as a healthcare enforcer soon enough.
Those so scared of losing brain function usually don't have enough to start with.
In the mean time it will attend at home it's Wednesday night Obama wine tasting TV session as it dreams of west wing global village control, and feels above the "beer summit".
Yes, that one probably LOVES the O, and after SHRIEKING "are people stupid!" will tell us O sucking down a beer "saved his brain cells".
Probably on 3 different pills from the pharmacy, too, for some strange condition.

By nvalhalla on 8/7/2009 1:48:07 PM , Rating: 2
My cousin was a smoker from ~10th grade. He quit smoking a few years ago and in less than a year was diagnosed a Paranoid Schizophrenic. The medication he's on now had brought him back to the way he was when he was smoking. I wonder if he was self medicating and didn't even realize it.

RE: Interesting
By Lord 666 on 8/7/2009 2:11:54 PM , Rating: 3
Or smoking triggered whatever genes the Paranoid Schizophrenic. I know someone who started smoking in college and then stopped, but was never the same. Granted, the average onset age of schizophrenia is 18, but based on your corresponding input, anything is a possibility.

RE: Interesting
By GlassHouse69 on 8/7/2009 2:34:50 PM , Rating: 2
smoking cannot trigger schizophrenia. they had it from emotional problems and bad lifestyle choices/friend choices in their teenage years, or from abuse or severe neglect in childhood.

man. thatd be funky if it could cause schiz.

RE: Interesting
By Lord 666 on 8/7/2009 2:42:20 PM , Rating: 3
Quitting has become only common recently. Previously, people smoked for life once hooked.

As smoking cessation programs become more popular, it will be interesting to see if the schizophrenia rate goes up.

Like you previously mentioned, smoking affects the brain in many ways; from getting it high chemically and by increasing CO

RE: Interesting
By nvalhalla on 8/7/2009 2:47:33 PM , Rating: 2
While I agree that smoking wasn't the cause of his schizophrenia, it isn't caused by childhood trauma or hangin' with the wrong crowd. It's a chemical imbalance in the brain. It's no more environmental than Cerebral Palsy.

RE: Interesting
By Parhel on 8/7/2009 3:51:16 PM , Rating: 2
It's no more environmental than Cerebral Palsy.

I don't know where you heard that, but it's not true at all. Schizophrenia encompasses a wide range of the more severe mental disorders, so it's hard to make blanket statements about it. But, in most if not all cases, environment can be shown to have played a major role.

RE: Interesting
By nvalhalla on 8/7/2009 4:10:29 PM , Rating: 2
I had a feeling someone was going to jump on that. After I posted I realized I was oversimplifying. I was responding to his post that alluded to Schizophrenia being a product of his environment, something that could be fixed with therapy and a hug. The environment is a trigger, but there is an underlying physical condition that causes it. Thanks for making me clarify. :)

By here now on 8/8/2009 2:46:09 AM , Rating: 4
This science article really burns me up. Allow me to explain why. As you've read nicotine is a stimulant. And like all stimulants it speeds up cognitive processing.

Schizophrenics suffer from whole host varying problems including decreased cognitive processing speed, particularly executive functioning (frontal lobe), and reduced auditory & visual processing speed. They also have difficulty with concentration and short term memory.

The standard pharmaceutical treatment they take are neuroleptics (aka major tranquillisers) and these can slow down and dull the mind to a great extent depending on dosage. They can potentially reduce energy & stamina to a great degree. So those on the medication have an even greater desire to manage the drug side effects that interfere with their life, and often do so via stimulants like caffeine, smoking, or illicit drug use which counteract these symptoms. In effect this new nicotine medication being proposed would be in large part to deal with the significant negative side effects of the neuroleptic medication.

There are many other things they suffer from but these are all areas that stimulants improve on in the short term.

But here's the thing.... stimulants are addictive and lead to dependence. After a long enough period on stimulants the user loses the capacity to function properly without them, and hence develops a dependence. In all the cognitive areas that the stimulants initially improve upon, they eventually create a long lasting (in some cases permanent) deficit.

Nicotine in one of the drugs that has been documented to cause dependence and addiction. Ill tell you after 5-6 years of taking a nicotine schizophrenia treatment, those who've taken it that long will develop a new host of problems and/or exacerbate existing ones.

Nicotine and stimulants are host to their own boat load of side effects.

We are in effect promoting and re-enforcing their bad lifestyle which various companies will eventually be profiting off of it as well, and while giving them short term reprieve will be causing long term suffering.

RE: Unbelievable
By SiliconDoc on 8/14/2009 8:15:38 AM , Rating: 2
Not like it's any worse than the kidney and liver destroying anti=psychotics they forcibly jam down the throats of the brain injured population, at the threat of lockup or worse.
After cramming some insane debilitating combo of powerful brain function modifying drugs down their throats, basically to turn them into a degraded vegetative state (as you pointed out) they complain that the patients go off the killer drug cocktails (yes, there is enough self-preservation left in them that they have the sense to STOP choking down what's really killing them) too often, then blame the PSYCHOTIC EPISODE that follow on lack of medication rather than THE MOST SEVERE WITHDRAWAL ONE COULD POSSIBLY IMAGINE, FAR SURPASSING DETOX OF ANY STREET DRUG ADDICTION.
So, worrying about some nicotine dose that would never destroy people without a damaged brain diagnosis really, really misses the point entirely.
Furthermore, when some $160 dolar an hour dope peddling jerk off psychiatrist decies to try the latest drug or some other "combo" - they GANK the patient straight off the one cocktail and SLAM HOME the massive conversion ..
Of course who would listen to the PSYCHO screaming about the place as the new massively powerful cocktail of drugs kicks in while the detoxification and withdrawal from the former cocktail wreaks havoc on their entire body system ?
LOL - This is how "powerful government healthcare enforcement " works, beware fellow travellers, YOU HAVE BEEN WARNED!

Nicotine: Now with more good!
By poundsmack on 8/7/2009 1:13:31 PM , Rating: 2
I am looking for the "Study has been sponsored by big tobacco." it's got to be here somewhere.

By SiliconDoc on 8/14/2009 8:43:32 AM , Rating: 2
"Big government" paid for it, feller. Get a clue. Next, big government will pay for it another half dozen times, through Obamacare and the congressional porkulous process, and the dingleberry-headed collegiate quack crowd who are more concerned with mental illnesses than any other generation in the history of the entire world, since they're so doggone kooked out already, can enter the wrds and help it along and make observations on their test subjects. Then in the name of "cost savings" - the murder can really begin. ( you won't be whining about tobacco then - you'll be begging for a last meal and a smoke before they do the dirty but neccessary on yas _

Non-smoking Schizophrenics?
By Spacecomber on 8/7/2009 1:22:55 PM , Rating: 2
I wasn't clear from the DailyTech report, or the report's original source, whether the subjects under study had never smoked or were simply tobacco free for a period of time. I got the impression that the study was done with subjects who were in the process of being weaned from cigarettes.

They talked about subjects who hadn't had a cigarette for 12 hours and then was given a nicotine dose, but I got the impression this might have been done in an earlier study. It wasn't clear what were the conditions under which the subjects in the more recent study were nicotine free, though apparently they didn't think that withdrawal was a factor.

In any case, it seems that the real test would be to demonstrate improved functioning with schizophrenics who had never smoked. However, the original article notes that 70-90% percent of schizophrenics smoke; so, I can see that finding non-smokers might not be that easy.

RE: Non-smoking Schizophrenics?
By SiliconDoc on 8/14/2009 8:29:19 AM , Rating: 2
What ? You missed it.
" The new study, involved dosing the patients with nicotine. Describes Dr. Barr, "(W)e would ask participants to go without a cigarette for 12 hours and then provide a single dose of nicotine and measure cognitive function."
How is that not clear ? I suppose if you live in a nutball world you'd assume they "ask" non-smokers to go without a cigarette.

I could never smoke...
By SublimeSimplicity on 8/7/2009 1:25:44 PM , Rating: 2
I'm sure there are some schizophrenics out there who can't fathom breathing in cigarette smoke even if it's for their own good.

I wonder if you could do one of those nicotine patch programs backwards. You know, build up your addiction to overcome your hangups about smoking.

Could be an untapped market for hypnotists too.

RE: I could never smoke...
By Lord 666 on 8/7/2009 2:05:43 PM , Rating: 2
The source article is correct; about 70-90% of schizophrenics already smoke.

However, its part chicken vs egg if they developed the habit to self medicate or due to mental illness they adopted the habit.

There are several other drugs that would work similarly other than nicotine like Ritalin, ephedra, pseudoephedrine, etc.

wait, what?
By ku on 8/7/2009 1:47:44 PM , Rating: 2
This is new? I remember learning about this years ago. Stimulating the nicotine receptors in the brain help to offset some of the hyperdopaminergic irregularites. If I remember correctly, nicotine's remedying powers apply only to negative symptoms. I forget all of the exact details and studies, though. Typically, many schizophrenics will smoke 2+ packs a day, but it allows them to be much more functional (depending on which schizophrenic symptoms are most prevalent).

RE: wait, what?
By Parhel on 8/7/2009 3:54:16 PM , Rating: 2
The study is new, but the relationship between nicotine and schizophrenia has been recognized at least since the 1970's, maybe much earlier.

Minor correction
By evolveNow on 8/7/2009 4:39:30 PM , Rating: 4
One possibility is to develop schizophrenia drugs derived from nicotine -- so called "nicotine antagonists" -- which would bind to the same brain receptors (and have the same effect), but would not be converted by the liver into carcinogens.

It's AGONIST not antagonist. An Antagonist inhibits the binding to a receptor.

By enlil242 on 8/8/2009 4:15:11 PM , Rating: 2
That's what he said... Or, what I said... Or...

By Omega215D on 8/8/2009 8:15:53 PM , Rating: 2
I used to be crazy but we're all better now...
9 out 10 voices in my head say I'm not crazy.

(I know not schizophrenia but I couldn't resist)

They're all out to get me and if they aren't they soon will be because they're always out to get me...

Nicotine to help schizos . . .
By blueboy09 on 8/8/2009 5:59:07 PM , Rating: 2
Finally, there's a reason to start smoking!! The more of these poor souls that smoke the better. Rather have a schizo smoke to calm down than for them to raise hell for absolutely no reason . . . - BLUEBOY

By DarkElfa on 8/8/2009 10:37:15 PM , Rating: 2
They can have my cigs and pot when they pry it from my cold dead hands...

...or mine.

Who did the study?
By Zingam on 8/10/2009 12:56:46 PM , Rating: 2
Who did the study? Philip Moris? Some tobacco company?

RE: Who did the study?
By SiliconDoc on 8/14/2009 8:36:27 AM , Rating: 2
No worries, the patients will die from liver or kidney failure, or a massive heart attack, in their early 40's in all likelihood, due to the insanely powerful and debilitative affects of the massive tranQs the dope dealers force down their throats in the wards - there's not a chance in HELL nicotine will harm them -
So, no worries mr phillip morris prosecutor.
Work on moving your text of hatred on the big fat oil robber barrons, because the general population is choking down 100X the carbon soot footprint of smokers first and second hand smoke COMBINED, from the vehicular exhaust in ALL CITIES above 25K population in the USA - CURRENTLTY.
In other words, while the ciggies nazis are all about enforcing their tyranny, their big fat but plank vehicle below them is belching out the fumes equivalent to ten thoudsand smokers as they jaunt across town for their bristol latte'.
Good luck, you'll be fighting with the really insane on your side.

We would feel much better...
By Motoman on 8/7/2009 5:18:29 PM , Rating: 2
...if it weren't for the tricksy hobbitses that keep stealing our cigarettes! Filthy, stupid hobbitses! <Hack> <Hack>

By AshT on 8/10/2009 11:42:48 AM , Rating: 2
Would love to know exactly where her funding came from as 9/10 times its from the tobacco industry

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