New Method Turns Embryonic/Induced Pluripotent Stem Cells into Cardiac Muscle Cells
May 29, 2012 5:41 PM
comment(s) - last by
This finding can help researchers model diseases in the lab, and allow these diseases to be studied
Researchers from the University of Wisconsin-Madison have found a way to turn both embryonic and induced pluripotent
Sean Palecek, study leader and professor of chemical and biological engineering at the University of Wisconsin-Madison, along with Timothy Kamp, professor of cardiology at UW School of Medicine and Public Health, and Xiaojun Lian, a UW graduate student, have developed a technique for abundant cardiomyocyte production, which will allow scientists to better understand and treat diseases.
Cardiomyocytes are important cells that make up the beating heart. These cells are extremely difficult to obtain,
especially in large quantities
, because they only survive for a short period of time when retrieved from the human heart.
But now, the UW researchers have found an inexpensive method for developing an abundance of cardiomyocytes in the laboratory. This finding can help researchers model diseases in the lab, and allow these diseases to be studied. Researchers will also be able to tests drugs that could help fight these diseases, such as
"Many forms of heart disease are due to the loss or death of functioning cardiomyocytes, so strategies to replace heart cells in the diseased heart continue to be of interest,” said Kamp. "For example, in a large heart attack up to 1 billion cardiomyocytes die. The heart has a limited ability to repair itself, so being able to supply large numbers of potentially patient-matched cardiomyocytes could help."
The UW research team found that changing a signaling pathway called Wnt can help guide stem cell differentiation to cardiomyocytes. They just turned the Wnt pathway on and off at different times using two small molecule chemicals.
"Our protocol is more efficient and robust," said Palecek. "We have been able to reliably generate greater than 80 percent cardiomyocytes in the final population while other methods produce about 30 percent cardiomyocytes with high batch-to-batch variability.
"The biggest advantage of our method is that it uses small molecule chemicals to regulate biological signals. It is completely defined, and therefore more reproducible. And the small molecules are much less expensive than protein growth factors."
This study was published in the journal
Proceedings of the National Academy of Sciences
Just last month,
researchers from the University of Toronto's Institute of Biomaterials and Biomedical Engineering (IBBME)
created a method for growing stem cells in larger quantities as well. They
combined the stem cell creation process with a bioreactor, which provides stable environments for such processes. The cells were also grown in suspension, making the process more stable and safer for
more viable cells
By doing this, mouse cells were reprogrammed into pluripotent stem cells, which can become any kind of cell. They were then changed into cardiac cells.
This article is over a month old, voting and posting comments is disabled
5/30/2012 8:07:44 AM
These guys need to have lunch with the guy who can 3D print kidneys, see what they can come up with.
5/30/2012 10:31:24 AM
Now implant it in someone and have it take. The issue with stem cells isnt that you can make them into any cells of the human body... its that the only cells they can implant in you are your own cells or they are rejected. So you just killed what could have been a baby to make some useless heart cells that will never be implanted into anyone ever. Good job liberals.
Don't let the Repugs in on this
5/30/2012 11:15:25 AM
Or the Cathlicks either. they'll kill it with a law that says you can't do science on the heart.
"Paying an extra $500 for a computer in this environment -- same piece of hardware -- paying $500 more to get a logo on it? I think that's a more challenging proposition for the average person than it used to be." -- Steve Ballmer
Canadian Researchers Find Way to Grow Stem Cells in Larger Quantities
April 9, 2012, 2:15 PM
Scientists Harvest Stem Cells in Effort to Save Endangered Species
September 5, 2011, 4:34 PM
Stem Cell Technique Produces Colonies of Blood Cells from Patient's Existing Cells
July 18, 2011, 10:15 AM
Beating Heart Cells Created From Virus-Free Blood Cells
April 11, 2011, 5:16 PM
Nail Polish May Soon be Able to Detect Date Rape Drugs
August 26, 2014, 7:57 AM
SpaceX Falcon 9-R Rocket Suffers Malfunction, Self-Destructs During Test Flight
August 23, 2014, 9:36 AM
Texas Chosen as Site for SpaceX's First Commercial Launchpad
August 5, 2014, 1:44 PM
South Carolina Prison Finds Crashed Drone Carrying Drugs, Phones
August 1, 2014, 2:49 PM
NASA's Mars 2020 Rover Gains Seven New Instruments for Exploration
August 1, 2014, 1:30 PM
NASA Opportunity Rover Breaks Record for Most Miles Traveled on Another Planet
July 29, 2014, 1:38 PM
Most Popular Articles
HTC Preps Nexus 9 With Nvidia K1 64-Bit "Denver" SoC, Android L Onboard
September 10, 2014, 10:21 PM
Apple iPhone 6, iPhone 6 Plus Reviews Roll In
September 16, 2014, 9:13 PM
Big Media: If You Want Privacy, You're Probably a Pirate
September 18, 2014, 2:57 PM
Apple Cripples NFC in iPhone 6, 6+ With Developer Ban
September 17, 2014, 1:00 PM
Home Depot Credit Card Theft is the Biggest in History, 55 Million Cards Stolen
September 18, 2014, 7:53 PM
Latest Blog Posts
ISIS Imposes Ban on Teaching Evolution in Iraq
Sep 17, 2014, 5:22 PM
Space Terrorism is a Looming Threat For the United States
Apr 23, 2014, 7:47 PM
Facebook Aims to Provide Internet to "Every Person in the World" with Drones, Satellites
Apr 1, 2014, 10:20 AM
Retail Mobile Sites Experience Outages in Light of Simplexity's Bankruptcy
Mar 14, 2014, 8:48 AM
Tesla vs. BMW: Who Has the Safer EV?
Feb 1, 2014, 2:56 PM
More Blog Posts
Copyright 2014 DailyTech LLC. -
Terms, Conditions & Privacy Information