 A Belgian Blue cow shows off the super-musculature that myostatin blocking can produce. (Source: kottke.org)
 Wendy is a whippet endowed with myostatin blocking. Where whippets are typically slender, Wendy is bluky and tough. She has been studied by genetics researchers in the U.S. (Source: Canada.com)
 Humans with myostatin blocking have shown development of similar freakish strength. One such baby was recently born in Berlin, Germany (pictured), while another was born in Roosevelt Park, Mich. (Source: China Daily)
Scientists have demonstrated a way to selectively block myostatin production
Myostatin is a critical gene in the human body that plays a
regulatory role in many processes, including the deposition of fatty
tissue. It also blocks muscle growth. Animals or humans
born without the gene show freakish muscular growth and the ability
to perform athletic feats that take their peers years of dedication
and training.
Of course all that comes at a price.
Muscle building mandates a diet with more protein, which can put a
stress on organs like the kidneys (as well as placing additional
physical stress on them). Those with an unusually high amount
of muscle have been shown to live to shorter lifespans in some
studies, potentially due to increased rates of organ
failure.
Undeterred, researchers are pushing ahead to look at
ways to block myostatin and make us into supermen
(and women). Researchers at the National Children’s
Hospital (NCH) and Ohio State University have demonstrated
how gene therapy can be used to selectively upregulate follistatin in
muscles according to Singularity Hub. Fullistatin blocks myostatin, allowing for tremendous
gains. The macaque monkeys involved in the trial were endowed
with super biceps.
The center is now filing the preliminary
paperwork to start human trials. They insist that their goal is
not to make super people, but rather to help children and the elderly
with conditions that cause muscular dystrophy. Using the
blockers, children with Muscular Dystrophy (MD), a disease that
frequently leads to an early death, could develop musculature on par,
or even superior to their peers, raising their chance of survival.
In the elderly, the therapy could be used to combat
conditions that cause loss of musculature or muscle control.
This could lead to less accidents and improved energy.
As
mentioned, dangers of Myostatin blocking include an increased rate of
organ failure, possible effects on smooth muscle tissue, and damage
to tendons and ligaments. The briefer and more selective
application of the new gene therapy may somewhat reduce the risk of
the first two problems, but the long term effects on connective
tissue health remain to be seen.
As for the monkeys, after
receiving the treatment they continued to add muscle for close to 12
months. Their biceps increased 15 percent in circumference.
And one of the test subjects demonstrated an incredible 78 percent
increase in leg muscle strength when undergoing electrical
stimulation. Best of all, the monkeys showed no adverse affects
-- their organs seemed in perfect health.
So how far could
myostatin blocking take us? Well, to answer that, just look at
the story of Liam Hoekstra, a toddler from Roosevelt, Michigan, who
was born without the myostatin gene. Despite having to overcome
some tough birth defects, the youngster could stand up fully after
only two days. Within months the toddler was doing pull-ups,
inverted sit-ups, Olympics-ready iron crosses, and even punching
holes in his parents walls when he threw fits.
If
myostatin therapies hit the mainstream to treat age associated or
genetic muscular atrophy, it's hard to believe that some won't
use them for such athletic gains. However, we are approaching a
point where some of the dangers may be minimized. The fields of
organ
engineering and implantation are advancing rapidly. Today,
organs like the bladder have been successfully grown and implanted
into humans. So if our super muscles wear out our body, we may
be able to pop in some replacements, much like making a pit stop on
the race track.
The real question is -- how will these
advancements effect society? From those with super-vision via
artificial
lenses, to myostatin hulking behemoths, where will we draw the
line in terms of athletic competition and morality. That's an
intriguing question that will yet be debated by society.
"Well, we didn't have anyone in line that got shot waiting for our system." -- Nintendo of America Vice President Perrin Kaplan
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