Print 5 comment(s) - last by kamiller422.. on Apr 24 at 12:03 PM

The end result showed mice who scored much better on tests of learning and memory

Wisconsin researchers have used human embryonic stem cells to heal a damaged part of the brain in mice and restore their use of memory.

University of Wisconsin-Madison researchers, led by Su-Chun Zhang, have transformed the human embryonic stem cells into functional nerve cells -- which restored the ability to learn and remember in mice.

To do this, the research team used mice with damage to the medial septum, which connects to the hippocampus by GABA and cholinergic neurons and affects our ability to learn or remember. The mice were also a special kind, which are incapable of rejecting transplants from other species.

They then used chemicals (which encourage development into nerve cells) to culture the human embryonic stem cells in the lab. The cells started to differentiate into two types of neural cells (GABA and cholinergic neurons), and those were injected as intermediate cells. From there, the cells were directed through partial specialization to prevent the development of unwanted cell types and they were placed in the hippocampus.

After the transplant, the cells started to specialize and connect to the correct cells in the hippocampus as the brain doled out chemical directions.

The end result showed mice that scored much better on tests of learning and memory. For instance, there was a water maze test where they had to remember the location of a hidden platform within a pool.

"Cholinergic neurons are involved in Alzheimer's and Down syndrome, but GABA neurons are involved in many additional disorders, including schizophrenia, epilepsy, depression and addiction," said Zhang.

This means that this research could one day be used to treat -- or even cure -- medical conditions in the brain. 

Source: Eurekalert

Comments     Threshold

This article is over a month old, voting and posting comments is disabled

Here comes The Brain
By Shadowself on 4/22/2013 6:14:48 PM , Rating: 2
Pinky: "Gee, Brain, what do you want to do tonight?"
The Brain: "The same thing we do every night, Pinky—try to take over the world!"

((Never watched it myself, but my son said my grandsons were into it for a while.))

RE: Here comes The Brain
By FastEddieLB on 4/23/2013 2:16:11 AM , Rating: 2
What I remember of the show is it was highly entertaining for young children, watching this genius trying to take over the world with this idiot, yet tragically always falling just short of his goal... and even more tragically having it within his grasp completely unintentionally just to miss both the opportunity and the lesson that he was going about it the wrong way.

There was a great deal of insane troll logic going on in the show, but the writers always bent the rules of the world to make it work just right for the episode. There's some adult humor sprinkled here and there, like a tribute to Orson Wells for example, so give it a shot if you're really interested and have some time on your hands.

RE: Here comes The Brain
By CZroe on 4/23/2013 11:50:38 PM , Rating: 2
I always wanted one of Pinky's off-the-wall "I think so Brain..." reactions to Brain's "are you thinking what I'm thinking?" questions to trigger an epiphany for Brain that would make him succeed, but only by abandoning his plan and going with Pinky's crazy one. :)

Anyone want to teach these mice?
By ct760ster on 4/22/2013 6:46:24 PM , Rating: 2
Anyone want to teach these mice how to ride a motorbike, albeit a miniature one, and send them to Mars. Maybe in the future that's the way to conquer the new frontiers (^??)

By kamiller422 on 4/24/2013 12:03:50 PM , Rating: 2
Adult stem cells have shown many successes. Harvesting humans for the benefit of other humans is unjust. If possible to acquire embryonic cells without harvesting a human, I'm all for it.

"We shipped it on Saturday. Then on Sunday, we rested." -- Steve Jobs on the iPad launch
Related Articles

Copyright 2016 DailyTech LLC. - RSS Feed | Advertise | About Us | Ethics | FAQ | Terms, Conditions & Privacy Information | Kristopher Kubicki