quote: Mitochondrial DNA Analysis Mitochondrial DNA analysis (mtDNA) can be used to examine the DNA from samples that cannot be analyzed by RFLP or STR. Nuclear DNA must be extracted from samples for use in RFLP, PCR, and STR; however, mtDNA analysis uses DNA extracted from another cellular organelle called a mitochondrion. While older biological samples that lack nucleated cellular material, such as hair, bones, and teeth, cannot be analyzed with STR and RFLP, they can be analyzed with mtDNA. In the investigation of cases that have gone unsolved for many years, mtDNA is extremely valuable. All mothers have the same mitochondrial DNA as their offspring. This is because the mitochondria of each new embryo comes from the mother's egg cell. The father's sperm contributes only nuclear DNA. Comparing the mtDNA profile of unidentified remains with the profile of a potential maternal relative can be an important technique in missing-person investigations.
quote: In the investigation of cases that have gone unsolved for many years, mtDNA is extremely valuable
quote: Mitochondrial DNA analysis (mtDNA) can be used to examine the DNA from samples that cannot be analyzed by RFLP or STR... In the investigation of cases that have gone unsolved for many years, mtDNA is extremely valuable.
quote: The Mitochondrial DNA Unit began analyzing biological samples for mitochondrial DNA (mtDNA) in the fall of 2005. Two general categories of casework are accepted: criminal and missing persons/unidentified human remains. Typically, mtDNA analysis is utilized for those specimens where the quality and/or quantity of DNA are insufficient for nuclear DNA analysis (e.g., hair, bones, and teeth)... Suppose that a kidnapping victim is missing but a bloodstain is found in the suspect’s vehicle and only a maternal relative’s (e.g., mother, sibling) reference sample is available for the victim. In that case, mtDNA analysis could be conducted using a portion of the vehicle bloodstain, the maternal relative’s reference sample, and the suspect’s reference sample...
quote: The first mitochondrial DNA analysis that aided in a criminal conviction involved a suspect charged with the 1996 rape and murder of a young child in Tennessee. Since then, hundreds of cases have been examined using mitochondrial DNA analysis, and dozens have successfully been tried in the courtroom. A sizeable body of peer-reviewed scientific literature on forensic mitochondrial DNA analysis is available, and courtroom admissibility hearings have uniformly allowed its introduction worldwide .
quote: but there is very little variation within mDNA to begin with since there just aren't that many genes in the little DNA ring
quote: lawyers trying to make it out to be more then it is to get their clients out of jail.
quote: Even in light of these findings, aren't the chances of mDNA from a crime scene and a random innocent person matching extremely low?