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Print 15 comment(s) - last by curiousgeorgie.. on Dec 5 at 3:35 AM


the Dollies  (Source: dailymail.co.uk)
Nicknamed "the Dollies," four new sheep share exact genetic traits with Dolly

Seven years after the death of Dolly, a female sheep who was the first to be cloned using an adult somatic cell, four new sheep have been cloned using Dolly's frozen tissue sample that has been sitting in a freezer since her death in 2003.

Professor Keith Campbell, one of the original biologists who cloned Dolly, is keeping the four new quads on his land at the University of Nottingham as pets. They have been nicknamed "the Dollies," since they are exact copies of Dolly genetically. 

In 1996, Dolly, who was named after the country singer Dolly Parton, was cloned at the Roslin Institute near Edinburgh in Scotland. She was the first mammal to be cloned using an adult cell from a mammary gland, and was praised as a scientific phenomenon in headlines worldwide. But as she aged, Dolly experienced several health complications such as arthritis and advanced lung disease. At the young age of six, Dolly was put down because of her poor health. 

But Dolly lives on. Her leftover sample of tissue has remained in the freezer all these years later, and now four exact replicas carry her DNA

Campbell cloned the Dollies to see if improvements made to the cloning technique prevented the health problems that Dolly suffered within the new sheep. So far, Campbell says the Dollies are doing fine and that they are being watched very closely. 

"We are not doing anything to them," said Campbell. "They have no health concerns and they show none of the signs of developing the arthritis that Dolly had."

In addition to being healthier than Dolly, the Dollies were also easier to clone. During Dolly's cloning process, 277 eggs were used to create 29 embryos and only Dolly survived. With the Dollies, only five embryos were required to produce each of the four Dollies. 

The Dollies are already three and a half years old, but Campbell did not mention their existence until a recent lecture at the European Parliament debate on cloning and animal welfare. He is looking to publish further detail on the Dollies in a scientific journal, noting that the cloning technology is improving but not yet perfect. 

Several different groups are taking interest in the Dollies, such as animal welfare campaigners and stem cell scientists. Animal welfare campaigners have detailed the suffering that clones and surrogates experience during the cloning process, and Peter Stevenson of Compassion in World Farming has even said that "cloning is a welfare disaster."

Despite the critics, Campbell insists that improved technology has put the Dollies at less of a risk of health problems, and that the four sheep "got the life of Reilly - they potter around and get fed."



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What?
By Flunk on 12/2/2010 11:46:58 AM , Rating: 5
"Animal welfare campaigners have detailed the suffering that clones and surrogates experience during the cloning process"

How can they possibly know that? How does the cloned animal even know that they are a clone? It's not like embryos remember things. Maybe the surrogates suffer, I'm not too sure how that process works.




RE: What?
By christojojo on 12/2/2010 11:52:21 AM , Rating: 5
Just mention the word animal and someone is offended and worried about what us evil humans are doing to them thar animals


RE: What?
By kattanna on 12/2/2010 12:44:15 PM , Rating: 5
quote:
someone is offended and worried about what us evil humans are doing to them thar animals


i can tell you exactly what im doing to them.. eating them


RE: What?
By curiousgeorgieo on 12/5/2010 3:35:19 AM , Rating: 2
Dolly = The Jenova Project


RE: What?
By omnicronx on 12/2/2010 12:07:49 PM , Rating: 2
I just don't see how it could be any more intrusive than say.. artificial insemination (something which prospective mothers will volunteer to do..). Most of the work is done externally is it not?

The only thing I could think of is the failed pregnancies, that could impact the surrogates, and obviously the failed clones..


RE: What?
By Anoxanmore on 12/2/2010 1:53:51 PM , Rating: 2
I think it would work well to use a mother's DNA (who has no ovaries/eggs) and integrate that into either an artificial or existing egg and then use the father/donor's material to cause the pregancy to take place.

Although I think that technology is a couple decades off yet.

It would also be nice to be able to clone organs(using stem cells) so we don't have so many donor organ issues.


just how lonely does he get
By kattanna on 12/2/2010 11:41:12 AM , Rating: 2
so.. just how lonely does this guy get that he needs 4 sheep?

;>)

being serious though, its good to see them continue working on this




RE: just how lonely does he get
By omnicronx on 12/2/2010 11:44:52 AM , Rating: 2
quote:
being serious though, its good to see them continue working on this
I don't agree. I'm afraid Apple may buy the technology to keeps its userbase in line with Android =X..


RE: just how lonely does he get
By drycrust3 on 12/2/2010 2:01:24 PM , Rating: 4
quote:
I'm afraid Apple may buy the technology

So you will have the iMarino from Apple, Lambix from the open source community, which will serve as a skeleton for new sheep distributions such as OpenSusheep, Lambuntu, and Google's Ramdroid, while Wool 7 from Muttonsoft will be closed source and be very popular, but will be plagued by various forms of malware, such as viruses and worms.


RE: just how lonely does he get
By omnicronx on 12/2/2010 3:04:19 PM , Rating: 2
I was more or less getting at the creation of more sheep (har har).. but that works too ;)


next cloning challenge...
By johnsonx on 12/2/2010 11:53:41 AM , Rating: 4
time to clone some mint sauce




RE: next cloning challenge...
By tastyratz on 12/2/2010 3:58:55 PM , Rating: 2
or a nice cherry glaze


The reasons differ
By amanojaku on 12/2/2010 12:07:18 PM , Rating: 3
But both Dollies make your mouth water. ;-p~




RE: The reasons differ
By ClownPuncher on 12/2/2010 12:33:18 PM , Rating: 3
Trolling the nursing home for some 'tang? For shame!


Warning, corniness follows
By uhgotnegum on 12/2/2010 1:58:37 PM , Rating: 4
There may be four new "Dolly"s, but they will never be Dolly PartONE!!!!!!

...seriously, I warned you




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