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Non-union bone fracture  (Source: hkcos.org)
Mesenchymal stem cells enriched with IGF-1 helps heal bone fractures that could not mend themselves

An estimated 7.9 million bone fractures occur annually in the United States at an approximate cost of $70 billion. Of this number, about 10 to 20 percent do not heal. To address this problem researchers from the University of North Carolina at Chapel Hill School of Medicine have combined adult stem cells and a bone-generating hormone to correct bone fractures that do not heal.
 
Anna Spagnoli, MD, associate professor of pediatrics and biomedical engineering, and a team of researchers, have used an animal study to show that the transplantation of adult stem cells, which are combined with a bone-regenerating hormone, can heal bone fractures.

Bone fractures that do not heal within a normal period of time are referred to as non-union fractures. In the study, researchers used a mouse with a non-union fracture in order to transplant adult stem cells enriched with the bone-regenerating hormone IGF-1. 

Mesenchymal stem cells taken from the bone marrow of adult mice was engineered to express IGF-I, and put the stem cells into the others non-union fracture in the tibia. Then, using computed tomography (CT) scanning; Spagnoli found that mice treated with the stem cells enriched with IGF-1 healed better than those treated with stem cells alone or not treated at all. 

"We envision a clinical use of combined mesenchymal stem cells and IGF-1 similar to the approach employed in bone marrow transplant, in which stem cell therapy is combined with growth factors to restore blood cells," said Spagnoli. "I think this treatment will be feasible to start testing in patients in a few years."

This research was presented at The Endocrine Society's 93rd Annual Meeting in Boston, Massachusetts on Sunday, June 5.



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Stem Cells?
By SSDMaster on 6/6/2011 11:43:37 AM , Rating: 3
Just get Stim Pack.




RE: Stem Cells?
By Kurz on 6/6/2011 11:58:59 AM , Rating: 2
Take some Rad-X while you are at it.


RE: Stem Cells?
By tenchymuyo2 on 6/6/2011 1:16:38 PM , Rating: 2
Don't forget some Med-X. Maybe some Psycho for later.


RE: Stem Cells?
By ARoyalF on 6/6/2011 10:02:09 PM , Rating: 2
Don't forget buffout with a beer chaser.......


RE: Stem Cells?
By Flunk on 6/6/2011 12:04:55 PM , Rating: 2
What did you think was in those stim packs?


RE: Stem Cells?
By StevoLincolnite on 6/6/2011 2:27:18 PM , Rating: 2
Redbull? :P


Meniscus application?
By chrnochime on 6/6/2011 11:01:45 AM , Rating: 3
So I guess this should also work with meniscus tears/fractures? Wonder if this would also heal the end points of femur and tibia, so knee replacements would no longer be a requirement.




RE: Meniscus application?
By Smartless on 6/6/2011 3:43:34 PM , Rating: 2
Hmm I wonder if we would need a mold for end of bone repair. As for meniscus tears or even ligament tears, wouldn't that be great? If we could repair these, I imagine geriatric care would make huge gains.


RE: Meniscus application?
By MarkHark on 6/6/2011 9:24:19 PM , Rating: 2
Lack of blood flow plays an important role on meniscus' lesions not healing.
I believe stem cell injections per se won't solve that problem.
Bone tissue, on the other hand, is quite abundantly vascularized.


RE: Meniscus application?
By MarkHark on 6/6/2011 9:26:16 PM , Rating: 2
Hallelujah! In over a year, this is my first comment to make it past the spam filter. :)


By Bubbacub on 6/10/2011 1:13:45 PM , Rating: 2
Just to give some context (as I am an orthopaedic surgeon), treatments like this are bandied about every few years. nothing has really been proven to work yet. the last 10 years or so have had people excited about using growth factors like BMP etc to treat non unions. after lots of interest after many mice and sheep butchering studies clinical trials have started - none which have really showed any benefit.

on a side note - when you break a tibia for example -one thing you do is shove a bloody great reamer down the intrmedullary canal - this chews up a load of bone marrow filled with growth factors and lovely stem cell like things and shoves them into the fracture site. is putting more of this in realistically going to make a difference? i hope it will and await the result of full clinical trials in years to come.




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